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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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July 2012 Volume 4 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Downregulation of inhibitor of growth 3 is correlated with tumorigenesis and progression of hepatocellular carcinoma

  • Authors:
    • Meiling Lu
    • Fei Chen
    • Qinwan Wang
    • Kesheng Wang
    • Qiuhui Pan
    • Xin Zhang
  • View Affiliations / Copyright

    Affiliations: The Central Laboratory, People's 10th Hospital, Shanghai 200072, P.R. China, Chinese National Human Genome Center at Shanghai, Shanghai 201203, P.R. China
  • Pages: 47-52
    |
    Published online on: April 19, 2012
       https://doi.org/10.3892/ol.2012.685
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Abstract

ING3, a member of the inhibitor of growth (ING) family, has been reported to be involved in transcription modulation, cell cycle control and the induction of apoptosis. Previous studies have demonstrated that the expression of ING3 decreased in melanoma and head and neck squamous cell carcinoma (HNSCC). The aim of this study was to investigate the role of ING3 in hepatocellular carcinoma (HCC) tumorigenesis and progression. The correlation between ING3 expression and clinicopathological variables of HCC was analyzed. Using the real-time reverse transcription-polymerase chain reaction (RT-PCR), it was found that ING3 was downregulated in HCC tissues compared with adjacent non-cancerous tissues (p<0.05). The immunohistochemical staining of tissue microarray data indicated a significant reduction of ING3 expression in 57.14% of HCC cases (64/112). In addition, the downregulation of ING3 was associated with the tumor differentiation stage. Most HCC samples of Edmondson-Steiner grades II to III exhibited inhibition of ING3 expression. The overexpression of ING3 in HCC cells was found to suppress cell proliferation, colony formation and cell migration, suggesting that ING3 acts as a tumor suppressor in HCC cells. Taken together, the data revealed that ING3 may serve as a suppression factor during tumorigenesis and progression of HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Lu M, Chen F, Wang Q, Wang K, Pan Q and Zhang X: Downregulation of inhibitor of growth 3 is correlated with tumorigenesis and progression of hepatocellular carcinoma. Oncol Lett 4: 47-52, 2012.
APA
Lu, M., Chen, F., Wang, Q., Wang, K., Pan, Q., & Zhang, X. (2012). Downregulation of inhibitor of growth 3 is correlated with tumorigenesis and progression of hepatocellular carcinoma. Oncology Letters, 4, 47-52. https://doi.org/10.3892/ol.2012.685
MLA
Lu, M., Chen, F., Wang, Q., Wang, K., Pan, Q., Zhang, X."Downregulation of inhibitor of growth 3 is correlated with tumorigenesis and progression of hepatocellular carcinoma". Oncology Letters 4.1 (2012): 47-52.
Chicago
Lu, M., Chen, F., Wang, Q., Wang, K., Pan, Q., Zhang, X."Downregulation of inhibitor of growth 3 is correlated with tumorigenesis and progression of hepatocellular carcinoma". Oncology Letters 4, no. 1 (2012): 47-52. https://doi.org/10.3892/ol.2012.685
Copy and paste a formatted citation
x
Spandidos Publications style
Lu M, Chen F, Wang Q, Wang K, Pan Q and Zhang X: Downregulation of inhibitor of growth 3 is correlated with tumorigenesis and progression of hepatocellular carcinoma. Oncol Lett 4: 47-52, 2012.
APA
Lu, M., Chen, F., Wang, Q., Wang, K., Pan, Q., & Zhang, X. (2012). Downregulation of inhibitor of growth 3 is correlated with tumorigenesis and progression of hepatocellular carcinoma. Oncology Letters, 4, 47-52. https://doi.org/10.3892/ol.2012.685
MLA
Lu, M., Chen, F., Wang, Q., Wang, K., Pan, Q., Zhang, X."Downregulation of inhibitor of growth 3 is correlated with tumorigenesis and progression of hepatocellular carcinoma". Oncology Letters 4.1 (2012): 47-52.
Chicago
Lu, M., Chen, F., Wang, Q., Wang, K., Pan, Q., Zhang, X."Downregulation of inhibitor of growth 3 is correlated with tumorigenesis and progression of hepatocellular carcinoma". Oncology Letters 4, no. 1 (2012): 47-52. https://doi.org/10.3892/ol.2012.685
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