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Article

Co-expression of ERCC1 and Snail is a prognostic but not predictive factor of cisplatin-based neoadjuvant chemotherapy for bladder cancer

  • Authors:
    • Atsunari Kawashima
    • Hitoshi Takayama
    • Norihiko Kawamura
    • Noriteru  Doi
    • Mototaka Sato
    • Koji Hatano
    • Akira Nagahara
    • Motohide Uemura
    • Yasutomo Nakai
    • Kensaku Nishimura
    • Susumu Miyoshi
    • Kiyoshi  Kawano
    • Kazuo Nishimura
    • Norio Nonomura
    • Akira Tsujimura
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan, Department of Urology, Osaka Rosai Hospital, Sakai, Japan, Department of Pathology, Osaka Rosai Hospital, Sakai, Japan, Department of Urology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
  • Pages: 15-21
    |
    Published online on: April 23, 2012
       https://doi.org/10.3892/ol.2012.689
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Abstract

Neoadjuvant chemotherapy (NC) for bladder cancer has been reported to significantly improve the 5-year survival rate. The aim of the present study was to examine the roles of ERCC1 and Snail in determining the response to chemotherapy in bladder cancer treated with NC and radical cystectomy (RC). The expression of the Snail and ERCC1 proteins was determined by immunohistochemical staining of specimens obtained from 58 patients with bladder tumors treated with NC and RC. The correlation between clinical response and the expression of Snail and ERCC1 was investigated. Snail and ERCC1 were co-expressed in 24 (41.4%) of the 58 patients. A marked correlation was found between the expression of Snail and ERCC1 (P=0.001). The co-expression of Snail and ERCC1 was not able to predict pathological complete response (P=0.202). Results of the univariate analysis revealed that the co-expression of Snail and ERCC1 predicted shorter disease-free survival (DFS) and overall survival (OS) than the negative expression of Snail and/or ERCC1. Moreover, the co-expression of ERCC1 and Snail was the only predictive factor for both DFS (P=0.029) and OS (P=0.040). The expression of Snail was correlated with that of ERCC1 and the co-expression of Snail and ERCC1 was the only significant predictive factor of shorter DFS and OS in patients with bladder cancer treated with NC and RC.
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Copy and paste a formatted citation
Spandidos Publications style
Kawashima A, Takayama H, Kawamura N, Doi N, Sato M, Hatano K, Nagahara A, Uemura M, Nakai Y, Nishimura K, Nishimura K, et al: Co-expression of ERCC1 and Snail is a prognostic but not predictive factor of cisplatin-based neoadjuvant chemotherapy for bladder cancer. Oncol Lett 4: 15-21, 2012.
APA
Kawashima, A., Takayama, H., Kawamura, N., Doi, N., Sato, M., Hatano, K. ... Tsujimura, A. (2012). Co-expression of ERCC1 and Snail is a prognostic but not predictive factor of cisplatin-based neoadjuvant chemotherapy for bladder cancer. Oncology Letters, 4, 15-21. https://doi.org/10.3892/ol.2012.689
MLA
Kawashima, A., Takayama, H., Kawamura, N., Doi, N., Sato, M., Hatano, K., Nagahara, A., Uemura, M., Nakai, Y., Nishimura, K., Miyoshi, S., Kawano, K., Nishimura, K., Nonomura, N., Tsujimura, A."Co-expression of ERCC1 and Snail is a prognostic but not predictive factor of cisplatin-based neoadjuvant chemotherapy for bladder cancer". Oncology Letters 4.1 (2012): 15-21.
Chicago
Kawashima, A., Takayama, H., Kawamura, N., Doi, N., Sato, M., Hatano, K., Nagahara, A., Uemura, M., Nakai, Y., Nishimura, K., Miyoshi, S., Kawano, K., Nishimura, K., Nonomura, N., Tsujimura, A."Co-expression of ERCC1 and Snail is a prognostic but not predictive factor of cisplatin-based neoadjuvant chemotherapy for bladder cancer". Oncology Letters 4, no. 1 (2012): 15-21. https://doi.org/10.3892/ol.2012.689
Copy and paste a formatted citation
x
Spandidos Publications style
Kawashima A, Takayama H, Kawamura N, Doi N, Sato M, Hatano K, Nagahara A, Uemura M, Nakai Y, Nishimura K, Nishimura K, et al: Co-expression of ERCC1 and Snail is a prognostic but not predictive factor of cisplatin-based neoadjuvant chemotherapy for bladder cancer. Oncol Lett 4: 15-21, 2012.
APA
Kawashima, A., Takayama, H., Kawamura, N., Doi, N., Sato, M., Hatano, K. ... Tsujimura, A. (2012). Co-expression of ERCC1 and Snail is a prognostic but not predictive factor of cisplatin-based neoadjuvant chemotherapy for bladder cancer. Oncology Letters, 4, 15-21. https://doi.org/10.3892/ol.2012.689
MLA
Kawashima, A., Takayama, H., Kawamura, N., Doi, N., Sato, M., Hatano, K., Nagahara, A., Uemura, M., Nakai, Y., Nishimura, K., Miyoshi, S., Kawano, K., Nishimura, K., Nonomura, N., Tsujimura, A."Co-expression of ERCC1 and Snail is a prognostic but not predictive factor of cisplatin-based neoadjuvant chemotherapy for bladder cancer". Oncology Letters 4.1 (2012): 15-21.
Chicago
Kawashima, A., Takayama, H., Kawamura, N., Doi, N., Sato, M., Hatano, K., Nagahara, A., Uemura, M., Nakai, Y., Nishimura, K., Miyoshi, S., Kawano, K., Nishimura, K., Nonomura, N., Tsujimura, A."Co-expression of ERCC1 and Snail is a prognostic but not predictive factor of cisplatin-based neoadjuvant chemotherapy for bladder cancer". Oncology Letters 4, no. 1 (2012): 15-21. https://doi.org/10.3892/ol.2012.689
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