Identification of multiple pathways involved in the malignant transformation of endometriosis (Review)
- Authors:
- Yumi Higashiura
- Hirotaka Kajihara
- Hiroshi Shigetomi
- Hiroshi Kobayashi
-
Affiliations: Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan - Published online on: April 23, 2012 https://doi.org/10.3892/ol.2012.690
- Pages: 3-9
This article is mentioned in:
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|
Rogers PA, D'Hooghe TM, Fazleabas A, et al: Priorities for endometriosis research: recommendations from an international consensus workshop. Reprod Sci. 16:335–346. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Gemmill JA, Stratton P, Cleary SD, Ballweg ML and Sinaii N: Cancers, infections, and endocrine diseases in women with endometriosis. Fertil Steril. 94:1627–1631. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Al-Jefout M, Tokushige N, Hey-Cunningham AJ, et al: Microanatomy and function of the eutopic endometrium in endometriosis. Expert Rev Obstet Gynecol. 4:61–79. 2009. View Article : Google Scholar | |
|
Brinton LA, Gridley G, Persson I, Baron J and Bergqvist A: Cancer risk after a hospital discharge diagnosis of endometriosis. Am J Obstet Gynecol. 176:572–579. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Brinton LA, Lamb EJ, Moghissi KS, et al: Ovarian cancer risk associated with varying causes of infertility. Fertil Steril. 82:405–414. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Kokcu A: Relationship between endometriosis and cancer from current perspective. Arch Gynecol Obstet. 284:1473–1479. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Nezhat F, Datta MS, Hanson V, Pejovic T and Nezhat C and Nezhat C: The relationship of endometriosis and ovarian malignancy: a review. Fertil Steril. 90:1559–15570. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Grammatikakis I, Zervoudis S, Evangelinakis N and Tziortzioti V: Endometrium and ovarian cancer synchronous to endometriosis - a retrospective study of our experience of 7 years. J Med Life. 3:76–79. 2010.PubMed/NCBI | |
|
Stern RC, Dash R, Bentley RC, Snyder MJ, Haney AF and Robboy SJ: Malignancy in endometriosis: frequency and comparison of ovarian and extraovarian types. Int J Gynecol Pathol. 20:133–139. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Mabrouk M, Vicenzi C, Ferrini G, et al: Mixed adenocarcinoma of the rectovaginal septum associated with endometriosis and endometrial carcinoma: a case report. Case Rep Oncol. 4:149–154. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Veiga-Castelli LC, Silva JC, Meola J, et al: Genomic alterations detected by comparative genomic hybridization in ovarian endometriomas. Braz J Med Biol Res. 43:799–805. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Wiegand KC, Shah SP, Al-Agha OM, et al: ARID1A mutations in endometriosis-associated ovarian carcinomas. N Engl J Med. 363:1532–1543. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Yamamoto S, Tsuda H, Takano M, Iwaya K, Tamai S and Matsubara O: PIK3CA mutation is an early event in the development of endometriosis-associated ovarian clear cell adenocarcinoma. J Pathol. 225:189–194. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Scott RB: Malignant changes in endometriosis. Obstet Gynecol. 2:283–289. 1953. | |
|
Scully RE, Richardson GS and Barlow JF: The development of malignancy in endometriosis. Clin Obstet Gynecol. 9:384–411. 1966. View Article : Google Scholar : PubMed/NCBI | |
|
Omranipour R and Najafi M: Papillary serous carcinoma arising in abdominal wall endometriosis treated with neoadjuvant chemotherapy and surgery. Fertil Steril. 93:1347.e17–e18. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Heaps JM, Nieberg RK and Berek JS: Malignant neoplasms arising in endometriosis. Obstet Gynecol. 75:1023–1028. 1990.PubMed/NCBI | |
|
Sayasneh A, Tsivos D and Crawford R: Endometriosis and ovarian cancer: a systematic review. ISRN Obstet Gynecol. 2011:1403102011. View Article : Google Scholar : PubMed/NCBI | |
|
Kobayashi H, Sumimoto K, Moniwa N, et al: Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan. Int J Gynecol Cancer. 17:37–43. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Takeuchi M, Matsuzaki K, Uehara H and Nishitani H: Malignant transformation of pelvic endometriosis: MR imaging findings and pathologic correlation. Radiographics. 26:407–417. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
McCluggage WG, Bryson C, Lamki H and Boyle DD: Benign, borderline, and malignant endometrioid neoplasia arising in endometriosis in association with tamoxifen therapy. Int J Gynecol Pathol. 19:276–279. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Martin DC: Cancer and endometriosis: do we need to be concerned? Semin Reprod Endocrinol. 15:319–324. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Cho KR and Shih IeM: Ovarian cancer. Annu Rev Pathol. 4:287–313. 2009. View Article : Google Scholar | |
|
Jones S, Wang TL, Shih IeM, et al: Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science. 330:228–231. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Guan B, Wang TL and Shih IM: ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers. Cancer Res. 71:6718–6727. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao C, Wu LS and Barner R: Pathogenesis of ovarian clear cell adenofibroma, atypical proliferative (borderline) tumor, and carcinoma: clinicopathologic features of tumors with endometriosis or adenofibromatous components support two related pathways of tumor development. J Cancer. 2:94–106. 2011. View Article : Google Scholar | |
|
Mandai M, Matsumura N, Baba T, Yamaguchi K, Hamanishi J and Konishi I: Ovarian clear cell carcinoma as a stress-responsive cancer: influence of the microenvironment on the carcinogenesis and cancer phenotype. Cancer Lett. 310:129–133. 2011. View Article : Google Scholar | |
|
Yamaguchi K, Mandai M, Toyokuni S, et al: Contents of endometriotic cysts, especially the high concentration of free iron, are a possible cause of carcinogenesis in the cysts through the iron-induced persistent oxidative stress. Clin Cancer Res. 4:32–40. 2008. View Article : Google Scholar | |
|
Kobayashi H, Kajiwara H, Kanayama S, et al: Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (Review). Oncol Rep. 22:233–240. 2009.PubMed/NCBI | |
|
Kuo KT, Mao TL, Jones S, et al: Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma. Am J Pathol. 174:1597–1601. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Yamamoto S, Tsuda H, Takano M, et al: Expression of platelet-derived growth factors and their receptors in ovarian clear-cell carcinoma and its putative precursors. Mod Pathol. 21:115–124. 2008.PubMed/NCBI | |
|
Kobayashi H, Yamada Y, Kanayama S, et al: The role of hepatocyte nuclear factor-1β in the pathogenesis of clear cell carcinoma of the ovary. Int J Gynecol Cancer. 19:471–479. 2009. | |
|
Fukunaga M, Nomura K, Ishikawa E and Ushigome S: Ovarian atypical endometriosis: its close association with malignant epithelial tumours. Histopathology. 30:249–255. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Srinivasan R, Gupta N and Gupta I: Recurrent endocervical-like mucinous borderline tumor (ELMBT) arising in a case of long-standing endometriosis - a case report. Indian J Pathol Microbiol. 49:277–278. 2006.PubMed/NCBI | |
|
Biscotti CV and Hart WR: Peritoneal serous micropapillomatosis of low malignant potential (serous borderline tumors of the peritoneum). A clinicopathologic study of 17 cases. Am J Surg Pathol. 16:467–745. 1992. View Article : Google Scholar : PubMed/NCBI | |
|
Tinelli A, Malvasi A and Pellegrino M: An incidental peritoneal serous borderline tumor during laparoscopy for endometriosis. Eur J Gynaecol Oncol. 30:579–582. 2009.PubMed/NCBI | |
|
Carlson J, Roh MH, Chang MC and Crum CP: Recent advances in the understanding of the pathogenesis of serous carcinoma: the concept of low- and high-grade disease and the role of the fallopian tube. Diagn Histopathol (Oxford). 14:352–365. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
McCoubrey A, Houghton O, McCallion K and McCluggage WG: Serous adenocarcinoma of the sigmoid mesentery arising in cystic endosalpingiosis. J Clin Pathol. 58:1221–1223. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Cil AP, Atasoy P and Kara SA: Myometrial involvement of tumor-like cystic endosalpingiosis: a rare entity. Ultrasound Obstet Gynecol. 32:106–110. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Kurman RJ and Shih IeM: The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory. Am J Surg Pathol. 34:433–443. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Mayr D, Hirschmann A, Löhrs U and Diebold J: KRAS and BRAF mutations in ovarian tumors: a comprehensive study of invasive carcinomas, borderline tumors and extraovarian implants. Gynecol Oncol. 103:883–887. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Hamada T, Kiyokawa T, Nomura K and Hano H: Immunohistochemical analysis of reserve cell-like cells of ovarian müllerian mucinous/mixed epithelial borderline tumor. Int J Gynecol Pathol. 27:199–206. 2008.PubMed/NCBI | |
|
Moriya T, Mikami Y, Sakamoto K, et al: Endocervical-like mucinous borderline tumors of the ovary: clinicopathological features and electron microscopic findings. Med Electron Microsc. 36:240–246. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Lee KR and Nucci MR: Ovarian mucinous and mixed epithelial carcinomas of mullerian (endocervical-like) type: a clinicopathologic analysis of four cases of an uncommon variant associated with endometriosis. Int J Gynecol Pathol. 22:42–51. 2003. View Article : Google Scholar | |
|
D'Angelo E, Dadmanesh F, Pecorelli S and Prat J: Squamous cell carcinoma of the ovary arising from a mucinous cystic tumor of endocervical (müllerian) type. Int J Gynecol Pathol. 29:529–532. 2010.PubMed/NCBI | |
|
Kim KR, Choi J, Hwang JE, et al: Endocervical-like (Müllerian) mucinous borderline tumours of the ovary are frequently associated with the KRAS mutation. Histopathology. 57:587–596. 2010. | |
|
Shin JH, Bae JH, Lee A, et al: CK7, CK20, CDX2 and MUC2 Immunohistochemical staining used to distinguish metastatic colorectal carcinoma involving ovary from primary ovarian mucinous adenocarcinoma. Jpn J Clin Oncol. 40:208–213. 2010. View Article : Google Scholar | |
|
Auner V, Kriegshäuser G, Tong D, et al: KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay. BMC Cancer. 9:1112009. View Article : Google Scholar : PubMed/NCBI | |
|
Patrelli TS, Gizzo S, Di Gangi S, Guidi G, Rondinelli M and Nardelli GB: Cervical Mullerian adenosarcoma with heterologous sarcomatous overgrowth: a fourth case and review of literature. BMC Cancer. 11:2362011. View Article : Google Scholar : PubMed/NCBI | |
|
McCluggage WG: Mullerian adenosarcoma of the female genital tract. Adv Anat Pathol. 17:122–129. 2010. View Article : Google Scholar | |
|
Han X, Leng J, Guo L, Xiang Y and Lang J: Vaginal adenosarcoma arising from refractory endometriosis: a case report. Aust N Z J Obstet Gynaecol. 50:574–576. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Patrelli TS, Silini EM, Gizzo S, et al: Extragenital Müllerian adenosarcoma with pouch of Douglas location. BMC Cancer. 11:1712011. | |
|
Singh R, Shameema S, Vijaya K and Kumar P: Mullerian adenosarcoma of the uterus with sarcomatous overgrowth. Clin Med Insights Case Rep. 3:27–30. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Chung YW, Bae HS, Han SI, Song JY, Kim IS and Kang JS: Endometrial mullerian adenosarcoma after toremifene treatment in breast cancer patients: a case report. J Gynecol Oncol. 21:269–272. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Yasuoka H, Tsujimoto M, Fujita S, et al: Coexistence of a clear cell adenocarcinoma and an adenosarcoma with a heterologous rhabdomyosarcoma in an endometriotic cyst of the ovary: a case study. Int J Gynecol Pathol. 28:362–366. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Clement PB and Scully RE: Mullerian adenosarcoma of the uterus. A clinicopathologic analysis of ten cases of a distinctive type of mullerian mixed tumor. Cancer. 34:1138–1149. 1974. View Article : Google Scholar : PubMed/NCBI | |
|
Gallardo A and Prat J: Mullerian adenosarcoma: a clinicopathologic and immunohistochemical study of 55 cases challenging the existence of adenofibroma. Am J Surg Pathol. 33:278–288. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Hrzenjak A, Moinfar F, Tavassoli FA, et al: JAZF1/JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase-polymerase chain reaction optimized for paraffin-embedded tissue. J Mol Diagn. 7:388–395. 2005. View Article : Google Scholar | |
|
Jung SI, Shin SS, Choi C, Hwang EC, Kim SO and Kang TW: Endometrial stromal sarcoma presenting as prevesical mass mimicking urachal tumor. J Korean Med Sci. 24:529–531. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Froio E, Piana S, Cavazza A, Valli R, Abrate M and Gardini G: Multifocal PEComa (PEComatosis) of the female genital tract associated with endometriosis, diffuse adenomyosis, and endometrial atypical hyperplasia. Int J Surg Pathol. 16:443–446. 2008. View Article : Google Scholar | |
|
Kim JY, Hong SY, Sung HJ, Oh HK and Koh SB: A case of multiple metastatic low-grade endometrial stromal sarcoma arising from an ovarian endometriotic lesion. J Gynecol Oncol. 20:122–125. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Khan AW, Craig M, Jarmulowicz M and Davidson BR: Liver tumours due to endometriosis and endometrial stromal sarcoma. HPB (Oxford). 4:43–45. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Baiocchi G, Kavanagh JJ and Wharton JT: Endometrioid stromal sarcomas arising from ovarian and extraovarian endometriosis: report of two cases and review of the literature. Gynecol Oncol. 36:147–151. 1990. View Article : Google Scholar : PubMed/NCBI | |
|
Roşca E, Venter A, Muţiu G, Drăgan A, Coroi M and Roşca DM: Endometrial stromal sarcoma developed on outer endometriosis foci. Rom J Morphol Embryol. 52:489–492. 2011.PubMed/NCBI | |
|
Chiang S and Oliva E: Cytogenetic and molecular aberrations in endometrial stromal tumors. Hum Pathol. 42:609–617. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Cheng CW, Smith SK and Charnock-Jones DS: Transcript profile and localization of Wnt signaling-related molecules in human endometrium. Fertil Steril. 90:201–204. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Irvin W, Pelkey T, Rice L and Andersen W: Endometrial stromal sarcoma of the vulva arising in extraovarian endometriosis: a case report and literature review. Gynecol Oncol. 71:313–316. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Viganó P, Somigliana E, Chiodo I, Abbiati A and Vercellini P: Molecular mechanisms and biological plausibility underlying the malignant transformation of endometriosis: a critical analysis. Hum Reprod Update. 12:77–89. 2006.PubMed/NCBI | |
|
Toyokuni S: Mysterious link between iron overload and CDKN2A/2B. J Clin Biochem Nutr. 48:46–49. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Toyokuni S: Molecular mechanisms of oxidative stress-induced carcinogenesis: from epidemiology to oxygenomics. IUBMB Life. 60:441–447. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Kajihara H, Yamada Y, Kanayama S, et al: Clear cell carcinoma of the ovary: Potential pathogenic mechanisms. Oncol Rep. 23:1193–1203. 2010.PubMed/NCBI | |
|
Yamada Y, Shigetomi H, Onogi A, et al: Redox-active iron-induced oxidative stress in the pathogenesis of clear cell carcinoma of the ovary. Int J Gynecol Cancer. 21:1200–1207. 2011.PubMed/NCBI | |
|
Mandai M, Yamaguchi K, Matsumura N, Baba T and Konishi I: Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management. Int J Clin Oncol. 14:383–391. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Yamaguchi K, Mandai M, Oura T, et al: Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes. Oncogene. 29:1741–1752. 2010. View Article : Google Scholar : PubMed/NCBI |
