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Review

Identification of multiple pathways involved in the malignant transformation of endometriosis (Review)

  • Authors:
    • Yumi Higashiura
    • Hirotaka Kajihara
    • Hiroshi Shigetomi
    • Hiroshi Kobayashi
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Nara Medical University, Nara, Japan
  • Pages: 3-9
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    Published online on: April 23, 2012
       https://doi.org/10.3892/ol.2012.690
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Abstract

The association between endometriosis and malignant transformation has often been described in the medical literature. A search was conducted between 1966 and 2010 through the English language literature (online Medline PubMed database) using the keywords endometriosis combined with malignant transformation. The search revealed an increase in reports describing endometriosis and malignancy. Approximately 1.0% of women with endometriosis have lesions that undergo malignant transformation. The malignant processes that are associated with endometriosis may be classified into three groups: i) epithelial ovarian cancers (endometrioid adenocarcinoma and clear cell carcinoma), ii) other Müllerian-type tumors, including Müllerian-type mucinous borderline tumor and serous borderline tumor and iii) sarcomas such as adenosarcoma and endometrial stromal sarcoma in the female pelvic cavity. Persistent oxidative stress induced by endometriosis-dependent hemorrhage may be associated with carcinogenesis. In conclusion, the malignant transformation of endometriosis has multiple pathways of development and may share a common pathogenic mechanism; iron-induced oxidative stress derived from repeated hemorrhage.
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Copy and paste a formatted citation
Spandidos Publications style
Higashiura Y, Kajihara H, Shigetomi H and Kobayashi H: Identification of multiple pathways involved in the malignant transformation of endometriosis (Review). Oncol Lett 4: 3-9, 2012.
APA
Higashiura, Y., Kajihara, H., Shigetomi, H., & Kobayashi, H. (2012). Identification of multiple pathways involved in the malignant transformation of endometriosis (Review). Oncology Letters, 4, 3-9. https://doi.org/10.3892/ol.2012.690
MLA
Higashiura, Y., Kajihara, H., Shigetomi, H., Kobayashi, H."Identification of multiple pathways involved in the malignant transformation of endometriosis (Review)". Oncology Letters 4.1 (2012): 3-9.
Chicago
Higashiura, Y., Kajihara, H., Shigetomi, H., Kobayashi, H."Identification of multiple pathways involved in the malignant transformation of endometriosis (Review)". Oncology Letters 4, no. 1 (2012): 3-9. https://doi.org/10.3892/ol.2012.690
Copy and paste a formatted citation
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Spandidos Publications style
Higashiura Y, Kajihara H, Shigetomi H and Kobayashi H: Identification of multiple pathways involved in the malignant transformation of endometriosis (Review). Oncol Lett 4: 3-9, 2012.
APA
Higashiura, Y., Kajihara, H., Shigetomi, H., & Kobayashi, H. (2012). Identification of multiple pathways involved in the malignant transformation of endometriosis (Review). Oncology Letters, 4, 3-9. https://doi.org/10.3892/ol.2012.690
MLA
Higashiura, Y., Kajihara, H., Shigetomi, H., Kobayashi, H."Identification of multiple pathways involved in the malignant transformation of endometriosis (Review)". Oncology Letters 4.1 (2012): 3-9.
Chicago
Higashiura, Y., Kajihara, H., Shigetomi, H., Kobayashi, H."Identification of multiple pathways involved in the malignant transformation of endometriosis (Review)". Oncology Letters 4, no. 1 (2012): 3-9. https://doi.org/10.3892/ol.2012.690
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