Ewing's sarcoma and primitive neuroectodermal tumour (ES/PNET) presenting as a breast mass

Chuthapisith,Suebwong; Prasert,Wilairat; Warnnissorn,Malee; Pradniwat,Kanapon; Srimuninnimit,Vichien; Angsusinha,Tamnit

doi:10.3892/ol.2012.698

July 2012 Volume 4 Issue 1

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July 2012 Volume 4 Issue 1

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Article

Ewing's sarcoma and primitive neuroectodermal tumour (ES/PNET) presenting as a breast mass

Authors:
- Suebwong Chuthapisith
- Wilairat Prasert
- Malee Warnnissorn
- Kanapon Pradniwat
- Vichien Srimuninnimit
- Tamnit Angsusinha
View Affiliations / Copyright

Affiliations: Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand, Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand, Thanyarak Breast Imaging Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Pages: 67-70
|
Published online on: April 27, 2012

https://doi.org/10.3892/ol.2012.698
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Abstract

Ewing's sarcoma/primitive neuroectodermal tumour (ES/PNET) is a rare tumour usually detected in young individuals and uncommonly found within the breast tissue. In this case report, we examined a 46-year-old patient, who developed a lump on her breast and was later diagnosed with ES/PNET. Clinical presentation, age at development and radiological findings were of interest and were discussed. Diagnosis of the tumour was confirmed using various immunohistochemical studies and the presence of a translocation, t(11;22). A literature review of this rare condition was also included.

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1	Baldini EH, Demetri GD, Fletcher CD, Foran J, Marcus KC and Singer S: Adults with Ewing’s sarcoma/primitive neuroecto-dermal tumor: adverse effect of older age and primary extraosseous disease on outcome. Ann Surg. 230:79–86. 1999.
2	Dehner LP: Primitive neuroectodermal tumor and Ewing’s sarcoma. Am J Surg Pathol. 17:1–13. 1993.
3	Jambhekar NA, Bagwan IN, Ghule P, Shet TM, Chinoy RF, Agarwal S, et al: Comparative analysis of routine histology, immunohistochemistry, reverse transcriptase polymerase chain reaction, and fluorescence in situ hybridization in diagnosis of Ewing family of tumors. Arch Pathol Lab Med. 130:1813–1818. 2006.
4	De Alava E and Gerald WL: Molecular biology of the Ewing’s sarcoma/primitive neuroectodermal tumor family. J Clin Oncol. 18:204–213. 2000.
5	Turc-Carel C, Philip I, Berger MP, Philip T and Lenoir GM: Chromosome study of Ewing’s sarcoma (ES) cell lines. Consistency of a reciprocal translocation t(11;22)(q24;q12). Cancer Genet Cytogenet. 12:1–19. 1984.
6	Martin RC and Brennan MF: Adult soft tissue Ewing sarcoma or primitive neuroectodermal tumors: predictors of survival? Arch Surg. 138:281–285. 2003. View Article : Google Scholar : PubMed/NCBI
7	Verrill MW, Judson IR, Harmer CL, Fisher C, Thomas JM and Wiltshaw E: Ewing’s sarcoma and primitive neuroectodermal tumor in adults: are they different from Ewing’s sarcoma and primitive neuroectodermal tumor in children? J Clin Oncol. 15:2611–2621. 1997.
8	Da Silva BB, Lopes-Costa PV, Pires CG, Borges RS and da Silva RG Jr: Primitive neuroectodermal tumor of the breast. Eur J Obstet Gynecol Reprod Biol. 137:248–249. 2008.PubMed/NCBI
9	Maxwell RW, Ghate SV, Bentley RC and Soo MS: Primary primitive neuroectodermal tumor of the breast. J Ultrasound Med. 25:1331–1333. 2006.PubMed/NCBI
10	Tamura G, Sasou S, Kudoh S, Kikuchi J, Ishikawa A, Tsuchiya T, et al: Primitive neuroectodermal tumor of the breast: immunohistochemistry and fluorescence in situ hybridization. Pathol Int. 57:509–512. 2007. View Article : Google Scholar : PubMed/NCBI
11	Milanezi F, Pereira EM, Ferreira FV, Leitao D and Schmitt FC: CD99/MIC-2 surface protein expression in breast carcinomas. Histopathology. 39:578–583. 2001. View Article : Google Scholar : PubMed/NCBI
12	Paulussen M, Ahrens S, Dunst J, Winkelmann W, Exner GU, Kotz R, et al: Localized Ewing tumor of bone: final results of the cooperative Ewing’s Sarcoma Study CESS 86. J Clin Oncol. 19:1818–1829. 2001.PubMed/NCBI
13	Rosito P, Mancini AF, Rondelli R, Abate ME, Pession A, Bedei L, et al: Italian Cooperative Study for the treatment of children and young adults with localized Ewing sarcoma of bone: a preliminary report of 6 years of experience. Cancer. 86:421–428. 1999.PubMed/NCBI
14	Verrill MW, Judson IR, Wiltshaw E, Thomas JM, Harmer CL and Fisher C: The use of paediatric chemotherapy protocols at full dose is both a rational and feasible treatment strategy in adults with Ewing’s family tumours. Ann Oncol. 8:1099–1105. 1997.PubMed/NCBI
15	Kushner BH, Hajdu SI, Gulati SC, Erlandson RA, Exelby PR and Lieberman PH: Extracranial primitive neuroectodermal tumors. The Memorial Sloan-Kettering Cancer Center experience. Cancer. 67:1825–1829. 1991. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Ewing's sarcoma and primitive neuroectodermal tumour (ES/PNET) presenting as a breast mass

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