Malignant granular cell tumor with breast metastasis: A case report and review of the literature

Chen,Jida; Wang,Linbo; Xu,Jing; Pan,Tao; Shen,Jianguo; Hu,Wenxian; Yuan,Xiaoming

doi:10.3892/ol.2012.702

July 2012 Volume 4 Issue 1

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July 2012 Volume 4 Issue 1

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Case Report

Malignant granular cell tumor with breast metastasis: A case report and review of the literature

Authors:
- Jida Chen
- Linbo Wang
- Jing Xu
- Tao Pan
- Jianguo Shen
- Wenxian Hu
- Xiaoming Yuan
View Affiliations / Copyright

Affiliations: Department of Surgical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China, Department of Pathology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China
Pages: 63-66
|
Published online on: May 2, 2012

https://doi.org/10.3892/ol.2012.702
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Abstract

Malignant granular cell tumors (MGCT) are rare mesenchymal soft tissue neoplasms of Schwann cell origin without adequate follow-up. This study describes a case of MGCT with right breast metastasis following two local recurrences. The patient consented to a right breast lumpectomy with right axillary dissection, a right abdominal wall lumpectomy and a right inguinal lumpectomy with dissection. Pathological examination revealed that the two initial lesions were consistent with benign histological performance. The later lesions were classified as malignant due to the observation of spindling of the tumor cells, vesicular nuclei with large nucleoli and increased mitotic rate. Immunohistochemical study of the lesions revealed positivity for S100 protein. The Ki-67 proliferation index increased from 1 to 10%. Twenty‑seven months after surgery, the patient was in good health with no sign of further tumor development. We recommend wide local excision with regional lymph node dissection as the first choice of treatment for MGCT.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Malignant granular cell tumor with breast metastasis: A case report and review of the literature

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