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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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August 2012 Volume 4 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Multidisciplinary management of very advanced stage III and IV melanoma: Proof-of-principle

  • Authors:
    • Haim Gutman
    • Eytan Ben-Ami
    • Roni Shapira-Frommer
    • Jacob Schachter
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Rabin Medical Center, Beilinson Campus, Tel Aviv University, Sackler School of Medicine, Israel, Ella Institute for Treatment and Research of Melanoma, Ch Sheba Medical Center, Tel Aviv University, Sackler School of Medicine, Israel
  • Pages: 307-310
    |
    Published online on: May 11, 2012
       https://doi.org/10.3892/ol.2012.712
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Abstract

Patients with potentially resectable advanced stage III and IV melanoma are a selected subgroup that gain maximal advantage if treated in a melanoma center. Surgery combined with chemo/chemobiotherapy may yield durable remission and long-term palliation. Thirty-seven non-randomly selected patients underwent systemic therapy with the aim of consolidating treatment by surgery. Data were collected prospectively, and analyzed retrospectively. The median follow-up from diagnosis was 50 (3-307) months and 15 (1-156) months when calculated from the last intervention. Twenty-two males and 15 females, with a median age at diagnosis of 44 (20-71) years, with 13 trunk, 13 extremity, 3 head and neck and 8 unknown primary melanomas were included. There were 17 stage III and 20 stage IV patients with a median Breslow thickness of 3.7 (0.45-26) mm. Chemo/chemobiotherapy achieved 7 clinical complete responses (cCRs), 28 partial responses (PRs) and 2 instances of stable disease. Six of the 7 cCRs were operated on, securing pathological complete response in 5 and PR in one. Four of these five and the PR patient still have no evidence of disease (NED). Twenty-one of 30 PR patients were rendered NED by surgery; 14 of these 21 patients succumbed to melanoma, and one is alive with stable disease. Overall, 11 of 37 patients have not succumbed to melanoma, with a median of 72 (14-156) months survival following the last intervention. Of the eight patients with unknown primary melanomas, five have not succumbed to melanoma, with a median of 89 (30-156) months survival following the last intervention. Patients with marginally resectable stage III and IV melanoma have a significant 30% chance, according to this series, for durable remission if treated by a multidisciplinary team in a melanoma center using induction chemobiotherapy and surgery. Results are more favorable for patients with an unknown primary lesion. In view of the currently approved new effective treatments for melanoma, this study may be considered a proof-of-principle investigation, enabling long-term remissions by combining induction therapy and surgery.
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Copy and paste a formatted citation
Spandidos Publications style
Gutman H, Ben-Ami E, Shapira-Frommer R and Schachter J: Multidisciplinary management of very advanced stage III and IV melanoma: Proof-of-principle. Oncol Lett 4: 307-310, 2012.
APA
Gutman, H., Ben-Ami, E., Shapira-Frommer, R., & Schachter, J. (2012). Multidisciplinary management of very advanced stage III and IV melanoma: Proof-of-principle. Oncology Letters, 4, 307-310. https://doi.org/10.3892/ol.2012.712
MLA
Gutman, H., Ben-Ami, E., Shapira-Frommer, R., Schachter, J."Multidisciplinary management of very advanced stage III and IV melanoma: Proof-of-principle". Oncology Letters 4.2 (2012): 307-310.
Chicago
Gutman, H., Ben-Ami, E., Shapira-Frommer, R., Schachter, J."Multidisciplinary management of very advanced stage III and IV melanoma: Proof-of-principle". Oncology Letters 4, no. 2 (2012): 307-310. https://doi.org/10.3892/ol.2012.712
Copy and paste a formatted citation
x
Spandidos Publications style
Gutman H, Ben-Ami E, Shapira-Frommer R and Schachter J: Multidisciplinary management of very advanced stage III and IV melanoma: Proof-of-principle. Oncol Lett 4: 307-310, 2012.
APA
Gutman, H., Ben-Ami, E., Shapira-Frommer, R., & Schachter, J. (2012). Multidisciplinary management of very advanced stage III and IV melanoma: Proof-of-principle. Oncology Letters, 4, 307-310. https://doi.org/10.3892/ol.2012.712
MLA
Gutman, H., Ben-Ami, E., Shapira-Frommer, R., Schachter, J."Multidisciplinary management of very advanced stage III and IV melanoma: Proof-of-principle". Oncology Letters 4.2 (2012): 307-310.
Chicago
Gutman, H., Ben-Ami, E., Shapira-Frommer, R., Schachter, J."Multidisciplinary management of very advanced stage III and IV melanoma: Proof-of-principle". Oncology Letters 4, no. 2 (2012): 307-310. https://doi.org/10.3892/ol.2012.712
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