Increased voltage-dependent K+ channel Kv1.3 and Kv1.5 expression correlates with leiomyosarcoma aggressiveness

Bielanska,Joanna; Hernández-Losa,Javier; Moline,Teresa; Somoza,Rosa; Ramón y Cajal,Santiago; Condom,Enric; Ferreres,Joan   Carles; Felipe,Antonio

doi:10.3892/ol.2012.718

August 2012 Volume 4 Issue 2

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August 2012 Volume 4 Issue 2

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Article

Increased voltage-dependent K+ channel Kv1.3 and Kv1.5 expression correlates with leiomyosarcoma aggressiveness

Authors:
- Joanna Bielanska
- Javier Hernández-Losa
- Teresa Moline
- Rosa Somoza
- Santiago Ramón y Cajal
- Enric Condom
- Joan Carles Ferreres
- Antonio Felipe
View Affiliations / Copyright

Affiliations: Molecular Physiology Laboratory, Department of Biochemistry and Molecular Biology, Institute of Biomedicine, University of Barcelona, E-08028 Barcelona, Spain, Department of Pathology, Vall d'Hebron University Hospital, Autonomous University of Barcelona, E-08035 Barcelona, Spain , Department of Pathology and Experimental Therapeutics, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, E-08907 Barcelona, Spain
Pages: 227-230
|
Published online on: May 16, 2012

https://doi.org/10.3892/ol.2012.718
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Abstract

Voltage-dependent K+ channels (Kv) are involved in the proliferation and differentiation of mammalian cells, since Kv antagonists impair cell cycle progression. Although myofibers are terminally differentiated, some myoblasts may re-enter the cell cycle and proliferate. Since Kv1.3 and Kv1.5 expression is remodeled during tumorigenesis and is involved in smooth muscle proliferation, the purpose of this study was to analyze the expression of Kv1.3 and Kv1.5 in smooth muscle neoplasms. In the present study, we examined human samples of smooth muscle tumors together with healthy specimens. Thus, leiomyoma (LM) and leiomyosarcoma (LMS) tumors were analyzed. Results showed that Kv1.3 was poorly expressed in the healthy muscle and indolent LM specimens, whereas aggressive LMS showed high levels of Kv1.3 expression. Kv1.5 staining was correlated with malignancy. The findings show a remodeling of Kv1.3 and Kv1.5 in human smooth muscle sarcoma. A correlation of Kv1.3 and Kv1.5 expression with tumor aggressiveness was observed. Thus, our results indicate Kv1.5 and Kv1.3 as potential tumorigenic targets for aggressive human LMS.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Increased voltage-dependent K+ channel Kv1.3 and Kv1.5 expression correlates with leiomyosarcoma aggressiveness

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Abstract

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