Tumor stem cells: A new approach for tumor therapy (Review)
- Authors:
- Min Meng
- Xin-Han Zhao
- Qian Ning
- Lei Hou
- Guo-Hong Xin
- Li-Feng Liu
-
Affiliations: Department of Oncology, The First Affiliated Hospital of Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China - Published online on: May 25, 2012 https://doi.org/10.3892/ol.2012.730
- Pages: 187-193
This article is mentioned in:
Abstract
Kondo T: Stem cell-like cancer cells in cancer cell lines. Cancer Biomark. 3:245–250. 2007.PubMed/NCBI | |
Dalerba P, Cho RW and Clarke MF: Cancer stem cells: models and concepts. Annu Rev Med. 58:267–284. 2007. View Article : Google Scholar : PubMed/NCBI | |
Reinwald M, Siehl JM, Goldin-Lang P, Menssen HD and Thiel E: Relative expression of Wilms-Tumor Gene (wt1) splice variants KTS−/E5−, KTS−/E5+, KTS+/E5− and KTS+/E5+ in AML patients reveals a similar pattern as in embryonic tissue. Blood. 98:206B. 2001. | |
La Spina M, Pizzolitto S, Skrap M, et al: Embryonal tumor with abundant neuropil and true rosettes. A new entity or only variations of a parent neoplasms (PNETs)? This is the dilemma. J Neuro-Oncol. 78:317–320. 2006.PubMed/NCBI | |
Cohnheim J: Ueber entzündung und eiterung. Virchows Arch. 40:1–79. 1867. | |
Furth J and Kahn M: The transmission of leukemia of mice with a single cell. Am J Cancer. 31:276–282. 1937. | |
Makino S and Kano K: Cytological studies of tumors. XIV Isolation of single-cell clones from a mixed-cell tumor of the rat. J Natl Cancer I. 15:1165–1181. 1955.PubMed/NCBI | |
Bonnet D and Dick JE: Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 3:730–737. 1997. View Article : Google Scholar : PubMed/NCBI | |
Blair A and Sutherland HJ: Primitive acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo lack surface expression of c-kit (CD117). Exp Hematol. 28:660–671. 2000. View Article : Google Scholar : PubMed/NCBI | |
Jordan C, Upchurch D, Szilvassy S, et al: The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia, stem cells. Leukemia. 14:1777–1784. 2000. View Article : Google Scholar : PubMed/NCBI | |
Hope KJ, Jin L and Dick JE: Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol. 5:738–743. 2004. View Article : Google Scholar : PubMed/NCBI | |
Rowley JD: The role of chromosome translocations in leukemogenesis. Semin Hematol. 36:59–72. 1999.PubMed/NCBI | |
Holyoake T, Jiang X, Eaves C and Eaves A: Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia. Blood. 94:2056–2064. 1999.PubMed/NCBI | |
Cobaleda C, Gutierrez-Cianca N, Perez-Losada J, et al: A primitive hematopoietic cell is the target for the leukemic transformation in human Philadelphia-positive acute lymphoblastic leukemia. Blood. 95:1007–1013. 2000. | |
Buchanan GR: 50 years ago in The Journal of Pediatrics - Treatment of Wilm’s tumor. J Pediatr. 148:812. 2006. | |
Wright JH: Neurocytoma or neuroblastoma, a kind of tumor not generally recognized. J Exp Med. 12:556–561. 1910. View Article : Google Scholar : PubMed/NCBI | |
Shimada H, Chatten J, Newton WA Jr, et al: Histopathologic prognostic factors in neuroblastic tumors: definition of subtypes of ganglioneuroblastoma and an age-linked classification of neuroblastomas. J Natl Cancer I. 73:405–416. 1984.PubMed/NCBI | |
O’Hare M: Teratomas, neoplasia and differentiation: a biological overview. I The natural history of teratomas. Invest Cell Pathol. 1:39–63. 1978.PubMed/NCBI | |
Pierce G Jr and Verney E: An in vitro and in vivo study of differentiation in teratocarcinomas. Cancer. 14:1017–1029. 1961. View Article : Google Scholar : PubMed/NCBI | |
Stevens LC: Experimental production of testicular teratomas in mice. Proc Natl Acad Sci USA. 52:654–661. 1964. View Article : Google Scholar : PubMed/NCBI | |
Stevens LC: Development of transplantable teratocarcinomas from intratesticular grafts of preimplantation and postimplantation mouse embryos. Dev Biol. 21:364–382. 1970. View Article : Google Scholar | |
Kleinsmith LJ and Pierce GB: Multipotentiality of single embryonal carcinoma cells. Cancer Res. 24:15441964.PubMed/NCBI | |
Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ and Clarke MF: Prospective identification of tumorigenic breast cancer cells. PNAS. 100:3983–3988. 2003. View Article : Google Scholar : PubMed/NCBI | |
Jordan CT: Cancer stem cell biology: from leukemia to solid tumors. Curr Opin Cell Biol. 16:708–712. 2004. View Article : Google Scholar : PubMed/NCBI | |
Kai K, Arima Y, Kamiya T and Saya H: Breast cancer stem cells. Breast Cancer. 17:80–85. 2010. View Article : Google Scholar : PubMed/NCBI | |
Ignatova TN, Kukekov VG, Laywell ED, Suslov ON, Vrionis FD and Steindler DA: Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia. 39:193–206. 2002. View Article : Google Scholar : PubMed/NCBI | |
Singh SK, Clarke ID, Terasaki M, et al: Identification of a cancer stem cell in human brain tumors. Cancer Res. 63:58212003.PubMed/NCBI | |
Piccirillo SGM and Vescovi AL: Brain tumour stem cells: possibilities of new therapeutic strategies. Expert Opin Biol Ther. 7:1129–1135. 2007. View Article : Google Scholar : PubMed/NCBI | |
Friedewald WF and Rous P: The initiating and promoting elements in tumor production - An analysis of the effects of tar, benzpyrene, and methylcholanthrene on rabbit skin. J Exp Med. 80:101–126. 1944. View Article : Google Scholar | |
Berenblum I: Carcinogenesis and tumor pathogenesis. Adv Cancer Res. 2:129–175. 1954. View Article : Google Scholar | |
Boutwell RK: Some biological aspects of skin carcinogenesis. Prog Exp Tumor Res. 4:207–250. 1964. View Article : Google Scholar : PubMed/NCBI | |
Potten CS and Morris RJ: Epithelial stem cells in vivo. J Cell Sci. (Suppl 10): 45–62. 1988. View Article : Google Scholar | |
Virchow R: Archiv fuer pathologische anatomie und physiologie und fuer klinische. Medizin. 8:231855. | |
Cohnheim J: Ueber entzündung und eiterung. Virchows Archiv. 40:1–79. 1867. | |
Beard J: Embryological aspects and etiology of carcinoma. Lancet. 1:1758–1761. 1902. View Article : Google Scholar | |
Rippert H: Geschwulstelehre fur Aerzte und Studierende Bonn. 1904 | |
Rotter H: Histogenese der malignen Geschwülste. J Cancer Res Clin. 18:171–208. 1922. | |
Brown K, Strathdee D, Bryson S, Lambie W and Balmain A: The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted. Curr Biol. 8:516–524. 1998. View Article : Google Scholar : PubMed/NCBI | |
Arnold I and Watt FM: c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny. Curr Biol. 11:558–568. 2001. View Article : Google Scholar : PubMed/NCBI | |
Munger K and Howley PM: Human papillomavirus immortalization and transformation functions. Virus Res. 89:213–228. 2002. View Article : Google Scholar : PubMed/NCBI | |
Pelengaris S, Littlewood T, Khan M, Elia G and Evan G: Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. Molecular Cell. 3:565–577. 1999. View Article : Google Scholar : PubMed/NCBI | |
Waikel RL, Kawachi Y, Waikel PA, Wang XJ and Roop DR: Deregulated expression of c-Myc depletes epidermal stem cells. Nat Genet. 28:165–168. 2001. View Article : Google Scholar : PubMed/NCBI | |
Akiyama T: Wnt/[beta]-catenin signaling. Cytokine Growth Factor Rev. 11:273–282. 2000. | |
Giles RH, van Es JH and Clevers H: Caught up in a Wnt storm: Wnt signaling in cancer. BBA-Rev Cancer. 1653:1–24. 2003.PubMed/NCBI | |
Koesters R and Doeberitz MV: The Wnt signaling pathway in solid childhood tumors. Cancer Lett. 198:123–138. 2003. View Article : Google Scholar : PubMed/NCBI | |
Peifer M and Polakis P: Cancer - Wnt signaling in oncogenesis and embryogenesis - a look outside the nucleus. Science. 287:1606–1609. 2000. View Article : Google Scholar : PubMed/NCBI | |
Kuhl M, Sheldahl LC, Park M, Miller JR and Moon RT: The Wnt/Ca2+ pathway - a new vertebrate Wnt signaling pathway takes shape. Trends Genet. 16:279–283. 2000. View Article : Google Scholar | |
Peifer M and McEwen DG: The ballet of morphogenesis: Unveiling the hidden choreographers. Cell. 109:271–274. 2002. View Article : Google Scholar : PubMed/NCBI | |
Liu CM, Li YM, Semenov M, et al: Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell. 108:837–847. 2002. View Article : Google Scholar : PubMed/NCBI | |
Aberle H, Bauer A, Stappert J, Kispert A and Kemler R: beta-catenin is a target for the ubiquitin-proteasome pathway. Embo J. 16:3797–3804. 1997. View Article : Google Scholar : PubMed/NCBI | |
Itoh K, Krupnik VE and Sokol SY: Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin. Curr Biol. 8:591–594. 1998. View Article : Google Scholar : PubMed/NCBI | |
Tetsu O and McCormick F: Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 398:422–426. 1999. View Article : Google Scholar : PubMed/NCBI | |
Yanagawa S, Matsuda Y, Lee JS, et al: Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila. Embo J. 21:1733–1742. 2002. View Article : Google Scholar : PubMed/NCBI | |
He TC, Sparks AB, Rago C, et al: Identification of c-MYC as a target of the APC pathway. Science. 281:1509–1512. 1998. View Article : Google Scholar : PubMed/NCBI | |
He X: A Wnt-Wnt situation. Developmental Cell. 4:791–797. 2003. View Article : Google Scholar | |
Morgan TH: The theory of the gene. Am Nat. 513–544. 1917. View Article : Google Scholar | |
Kidd S, Kelley MR and Young MW: Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth-factors. Mol Cell Biol. 6:3094–3108. 1986.PubMed/NCBI | |
Wharton KA, Johansen KM, Xu T and Artavanis-Tsakonas S: Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell. 43:5671985. View Article : Google Scholar : PubMed/NCBI | |
Hansson EM, Lendahl U and Chapman G: Notch signaling in development and disease. Semin Cancer Biol. 14:320–328. 2004. View Article : Google Scholar : PubMed/NCBI | |
Artavanis-Tsakonas S, Rand MD and Lake RJ: Notch signaling: Cell fate control and signal integration in development. Science. 284:770–776. 1999. View Article : Google Scholar : PubMed/NCBI | |
Christensen S, Kodoyianni V, Bosenberg M, Friedman L and Kimble J: lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H). Development. 122:1373–1383. 1996.PubMed/NCBI | |
Fryer CJ, Lamar E, Turbachova I, Kintner C and Jones KA: Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Gene Dev. 16:1397–1411. 2002. View Article : Google Scholar : PubMed/NCBI | |
Fortini ME and Artavanis-Tsakonas S: The suppressor of hairless protein participates in notch receptor signaling. Cell. 79:273–282. 1994. View Article : Google Scholar : PubMed/NCBI | |
Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R and Israel A: Signaling downstream of activated mammalian notch. Nature. 377:355–358. 1995. View Article : Google Scholar : PubMed/NCBI | |
Nam Y, Weng AP, Aster JC and Blacklow SC: Structural requirements for assembly of the CSL center dot Intracellular Notch1 center dot Mastermind-like 1 transcriptional activation complex. J Biol Chem. 278:21232–21239. 2003. View Article : Google Scholar : PubMed/NCBI | |
Schroeter EH, Kisslinger JA and Kopan R: Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature. 393:382–386. 1998. View Article : Google Scholar : PubMed/NCBI | |
Wu LZ, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S and Griffin JD: MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet. 26:484–489. 2000. View Article : Google Scholar : PubMed/NCBI | |
Aster JC and Pear WS: Notch signaling in leukemia. Curr Opin Hematol. 8:237–244. 2001. View Article : Google Scholar | |
Jeffries S, Robbins DJ and Capobianco AJ: Characterization of a high-molecular-weight notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line. Mol Cell Biol. 22:3927–3941. 2002. View Article : Google Scholar : PubMed/NCBI | |
Zweidler-McKay PA and Pear WS: Notch and T cell malignancy. Semin Cancer Biol. 14:329–340. 2004. View Article : Google Scholar | |
Callahan R and Raafat A: Notch signaling in mammary gland tumorigenesis. J Mammary Gland Biol. 6:23–36. 2001. View Article : Google Scholar : PubMed/NCBI | |
Fiúza UM and Arias AM: Cell and molecular biology of Notch. J Endocrinol. 194:459–474. 2007. | |
Ulasov IV, Nandi S, Dey M, Sonabend AM and Lesniak MS: Inhibition of Sonic Hedgehog and Notch pathways enhances sensitivity of CD133(+) glioma stem cells to temozolomide therapy. Mol Med. 17:103–112. 2011.PubMed/NCBI | |
Fitzgerald K, Harrington A and Leder P: Ras pathway signals are required for notch-mediated oncogenesis. Oncogene. 19:4191–4198. 2000. View Article : Google Scholar : PubMed/NCBI | |
Politi K, Feirt N and Kitajewski J: Notch in mammary gland development and breast cancer. Semin Cancer Biol. 14:341–347. 2004. View Article : Google Scholar : PubMed/NCBI | |
Shahi P, Seethammagari MR, Valdez JM, Xin L and Spencer DM: Wnt and Notch pathways have interrelated opposing roles on prostate progenitor cell proliferation and differentiation. Stem Cells. 29:678–688. 2011. View Article : Google Scholar : PubMed/NCBI | |
Nicolas M, Wolfer A, Raj K, et al: Notch1 functions as a tumor suppressor in mouse skin. Nat Genet. 33:416–421. 2003. View Article : Google Scholar : PubMed/NCBI | |
Shou JY, Ross S, Koeppen H, de Sauvage FJ and Gao WQ: Dynamics of notch expression during murine prostate development and tumorigenesis. Cancer Res. 61:7291–7297. 2001.PubMed/NCBI | |
Pesce M, Wang XY, Wolgemuth DJ and Scholer H: Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. Mech Develop. 71:89–98. 1998. View Article : Google Scholar : PubMed/NCBI | |
Pesce M, Gross MK and Schoeler HR: In line with our ancestors: Oct-4 and the mammalian germ. Bioessays. 20:1056. 1998. View Article : Google Scholar : PubMed/NCBI | |
Oliver RTD: Germ cell cancer. Curr Opin Oncol. 11:2361999. View Article : Google Scholar | |
Kraft HJ, Mosselman S, Smits HA, et al: Oct-4 regulates alternative platelet-derived growth factor alpha receptor gene promoter in human embryonal carcinoma cells. J Biol Chem. 271:12873–12878. 1996. View Article : Google Scholar | |
Zhou S, Morris JJ, Barnes YX, Lan L, Schuetz JD and Sorrentino BP: Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proc Natl Acad Sci USA. 99:12339–12344. 2002. View Article : Google Scholar : PubMed/NCBI | |
Zhou S, Schuetz JD, Bunting KD, et al: The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med. 7:1028–1034. 2001. View Article : Google Scholar : PubMed/NCBI | |
Gottesman MM, Fojo T and Bates SE: Multidrug resistance in cancer: Role of ATP-dependent transporters. Nat Rev Cancer. 2:48–58. 2002. View Article : Google Scholar : PubMed/NCBI | |
Akashi K, He X, Chen J, et al: Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood. 101:383–390. 2003. View Article : Google Scholar | |
Moserle L, Indraccolo S, Ghisi M, et al: The side population of ovarian cancer cells is a primary target of IFN-alpha antitumor effects. Cancer Res. 68:5658–5668. 2008. View Article : Google Scholar : PubMed/NCBI | |
Papapetrou EP, Tomishima MJ, Chambers SM, et al: Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation. Proc Natl Acad Sci USA. 106:12759–12764. 2009. View Article : Google Scholar : PubMed/NCBI | |
Takaishi S, Okumura T and Wang TC: Gastric cancer stem cells. J Clin Oncol. 26:2876–2882. 2008. View Article : Google Scholar : PubMed/NCBI | |
Ito R, Fukuda K, Saikawa Y, et al: Prospective identification of tumorigenic cells in human gastric cancer. Proc Am Assoc Cancer Res Annual Meeting. 49:1088–1089. 2008. | |
Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al: Identification and expansion of human colon-cancer-initiating cells. Nature. 445:111–115. 2007. View Article : Google Scholar : PubMed/NCBI | |
O’Brien CA, Pollett A, Gallinger S and Dick JE: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 445:106–110. 2007.PubMed/NCBI | |
Dalerba P, Dylla SJ, Park I-K, et al: Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci USA. 104:10158–10163. 2007. View Article : Google Scholar : PubMed/NCBI | |
Chiba T, Kita K, Zheng YW, et al: Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology. 44:240–251. 2006. View Article : Google Scholar : PubMed/NCBI | |
Chandrasekar PH and Ramesh M: Challenges in the management of invasive aspergillosis in hematopoietic stem cell transplantation. Expert Rev Anti Infect Ther. 7:1151–1153. 2009. View Article : Google Scholar : PubMed/NCBI |