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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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August 2012 Volume 4 Issue 2

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Review

Tumor stem cells: A new approach for tumor therapy (Review)

  • Authors:
    • Min Meng
    • Xin-Han Zhao
    • Qian Ning
    • Lei Hou
    • Guo-Hong Xin
    • Li-Feng Liu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 187-193
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    Published online on: May 25, 2012
       https://doi.org/10.3892/ol.2012.730
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Abstract

Recent studies have demonstrated the existence of a minority of tumor cells possessing the stem cell properties of self-renewal and differentiation in leukemia and several solid tumors. However, these cells do not possess the normal regulatory mechanisms of stem cells. Following transplantation, they are capable of initiating tumorigenesis and are therefore known as ‘tumor stem cells’. Cellular origin analysis of tumor stem cells has resulted in three hypotheses: Embryonal rest hypothesis, anaplasia and maturation arrest. Several signaling pathways which are involved in carcinogenesis, including Wnt/β-catenin, Notch and Oct-4 signaling pathways are crucial in normal stem cell self-renewal decisions, suggesting that breakdown in the regulation of self-renewal may be a key event in the development of tumors. Thus, tumors can be regarded as an abnormal organ in which stem cells have escaped from the normal constraints on self-renewal, thus, leading to abnormally differentiated tumor cells that lose the ability to form tumors. This new model for maligancies has significance for clinical research and treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Meng M, Zhao X, Ning Q, Hou L, Xin G and Liu L: Tumor stem cells: A new approach for tumor therapy (Review). Oncol Lett 4: 187-193, 2012.
APA
Meng, M., Zhao, X., Ning, Q., Hou, L., Xin, G., & Liu, L. (2012). Tumor stem cells: A new approach for tumor therapy (Review). Oncology Letters, 4, 187-193. https://doi.org/10.3892/ol.2012.730
MLA
Meng, M., Zhao, X., Ning, Q., Hou, L., Xin, G., Liu, L."Tumor stem cells: A new approach for tumor therapy (Review)". Oncology Letters 4.2 (2012): 187-193.
Chicago
Meng, M., Zhao, X., Ning, Q., Hou, L., Xin, G., Liu, L."Tumor stem cells: A new approach for tumor therapy (Review)". Oncology Letters 4, no. 2 (2012): 187-193. https://doi.org/10.3892/ol.2012.730
Copy and paste a formatted citation
x
Spandidos Publications style
Meng M, Zhao X, Ning Q, Hou L, Xin G and Liu L: Tumor stem cells: A new approach for tumor therapy (Review). Oncol Lett 4: 187-193, 2012.
APA
Meng, M., Zhao, X., Ning, Q., Hou, L., Xin, G., & Liu, L. (2012). Tumor stem cells: A new approach for tumor therapy (Review). Oncology Letters, 4, 187-193. https://doi.org/10.3892/ol.2012.730
MLA
Meng, M., Zhao, X., Ning, Q., Hou, L., Xin, G., Liu, L."Tumor stem cells: A new approach for tumor therapy (Review)". Oncology Letters 4.2 (2012): 187-193.
Chicago
Meng, M., Zhao, X., Ning, Q., Hou, L., Xin, G., Liu, L."Tumor stem cells: A new approach for tumor therapy (Review)". Oncology Letters 4, no. 2 (2012): 187-193. https://doi.org/10.3892/ol.2012.730
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