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Article

Reduced migration of Ishikawa cells associated with downregulation of aquaporin-5

  • Authors:
    • Xiu Xiu Jiang
    • Kai Hong Xu
    • Jun Yan Ma
    • Yong Hong Tian
    • Xiao Yan Guo
    • Jun Lin
    • Rui Jin Wu
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, P.R. China, Laboratory of Gynecology and Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, P.R. China
  • Pages: 257-261
    |
    Published online on: May 30, 2012
       https://doi.org/10.3892/ol.2012.738
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Abstract

Aquaporin (AQP)-dependent cell migration has broad implications in angiogenesis, tumor metastasis, wound healing, glial scarring and other events requiring cell movement. There are 13 isoforms of AQP (0-12) that have been identified in mammals. It is unclear whether AQP5 plays a role in the development of endometrial cancer. We recently demonstrated that ovarian steroids may affect the expression of AQP5 in the female genital tract. In this study, we considered whether AQP5 may affect cell migration in Ishikawa cells, an adenocarcinoma cell line derived from the endometrium. The results showed that the downregulation of AQP5 results in reduced Ishikawa cell migration. The estrogen (E2) receptor in the promoter of AQP5 mediated the regulation of AQP5 expression in the normal endometrium and endometrial cancer. By contrast, the upregulation of AQP5 by E2 increased cell migration, invasion and adhesion through increased annexin-2, which is responsible for F-actin remodeling and rearrangement. E2 regulates Ishikawa cell migration by regulating the AQP5 expression.
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1 

Verkman AS: More than just water channels: unexpected cellular roles of aquaporins. J Cell Sci. 118:3225–3232. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Aralla M, Borromeo V and Groppetti D: A collaboration of aquaporins handles water transport in relation to the estrous cycle in the bith uterus. Theriogenology. 72:310–321. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Zou LB, Zhang RJ, Tan YJ, et al: Identification of estrogen response element in the aquaporin-2 gene that mediates estrogen-induced cell migration and invasion in human endometrial carcinoma. J Clin Endocrinol Metab. 96:1399–1408. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Chang HL, Pieretti-Vanmarcke R, Nicolaou F, et al: Mullerian inhibiting substance inhibits invasion and migration of epithelial cancer cell lines. Gynecol Oncol. 120:128–134. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Asari T, Maruyama K and Kusama H: Salivation triggered by pilocarpine involves aquaporin-5 in normal rats but not in irradiated rats. Clin Exp Pharmacol Physiol. 36:531–538. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Skowronski MT, Kwon TH and Nielsen S: Immunolocalization of aquaporin 1, 5 and 9 in the female pig reproductive system. J Histochem Cytochem. 57:61–67. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Jiang XX, Wu RJ, Xu KH, Zhou CY, Guo XY, Sun YL and Lin J: Immunohistochemical detection of aquaporin expression in eutopic and ectopic endometria from women with endometriomas. Fertil Steril. 94:1229–1234. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Machida Y, Ueda Y, Shimasaki M, Sato K, Sagawa M, Katsuda S and Sakuma T: Relationship of aquaporin 1, 3, and 5 expression in lung cancer cells to cellular differentiation, invasive growth, and metastasis potential. Hum Pathol. 42:669–678. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Kang SK, Chae YK, Woo J, et al: Role of human aquaporin 5 in colorectal carcinogenesis. Am J Pathol. 173:518–525. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Yang JH, Shi YF, Cheng Q and Deng L: Expression and localization of aquaporin-5 in the epithelial ovarian tumors. Gynecol Oncol. 100:294–299. 2006. View Article : Google Scholar : PubMed/NCBI

11 

He RH, Sheng JZ, Luo Q, et al: Aquaporin-2 expression in human edometrium correlates with serum ovarian steroid hormones. Life Sci. 79:423–429. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Schaefer LWR, Fischer WR, et al: In vitro-Ishikawa cell test for assessing tissue-specific chemical effects on human endometrium. Reprod Toxicol. 30:89–93. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Ryan AJ, Susil B, Jobling TW and Oehler MK: Endometrial cancer. Cell Tissue Res. 322:53–61. 2005. View Article : Google Scholar

14 

Warth A, Kröger S and Wolburg H: Redistribution of aquaporin-4 in human glioblastoma correlates with loss of agrin immunoreactivity from brain capillary basal laminae. Acta Neuropathol. 107:311–318. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Saadoun S, Papadopoulos MC, Davies DC, Krishna S and Bell BA: Aquaporin-4 expression is increased in oedematous human brain tumours. J Neurol Neurosur Psychiatry. 72:262–265. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Ruiz-Ederra J and Verkman AS: Aquaporin-1 facilitated keratocyte migration in cell culture and in vivo corneal wound healing models. Exp Eye Res. 89:159–165. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Ding T, Gu F, Fu L and Ma YJ: Aquaporin-4 in glioma invasion and analysis of molecular mechanisms. J Clin Neurosci. 17:1359–1361. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Hayashi S, Takahashi N, Kurata N, Yamaguchi A, Matsui H, Kato S and Takeuchi K: Involvement of aquaporin-1 in gastric epithelial cell migration during wound repair. Biochem Bioph Res Commun. 386:483–487. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Papadopoulos MC, Saadoun S and Verkman AS: Aquaporins and cell migration. Pflug Arch. 456:693–700. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Nico B and Ribatti D: Aquaporins in tumor growth and angiogenesis. Cancer Lett. 294:135–138. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Hara-Chikuma M and Verkman AS: Prevention of skin tumorigenesis and impairment of epidermal cell proliferation by targeted aquaporin-3 gene disruption. Mol Cell Biol. 28:326–332. 2008. View Article : Google Scholar : PubMed/NCBI

22 

McCoy E and Sontheimer H: Expression and function of water channels (aquaporins) in migrating malignant astrocytes. Glia. 55:1034–1043. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Hara-Chikuma M and Verkman AS: Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing. J Mol Med (Berl). 86:221–231. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Ding T, Ma Y, Li W, Liu X, Ying G, Fu L and Gu F: Role of aquaporin-4 in the regulation of migration and invasion of human glioma cells. Int J Oncol. 38:1521–1531. 2011.PubMed/NCBI

25 

Assis ACM, Carvalho JL, Jacoby BA, et al: Time-dependent migration of systemically delivered bone marrow mesenchymal stem cells to the infarcted heart. Cell Transplant. 19:219–230. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Li HY, Liao CY, Lee KH, et al: Collagen IV significantly enhances migration and transplantation of embryonic stem cells: involvement of alpha 2 beta 1 integrin-mediated actin remodeling. Cell Transplant. 20:893–907. 2011. View Article : Google Scholar

27 

Behrstock S, Ebert AD, Klein S, Schmitt M, Moore JM and Svendsen CN: Lesion-induced increase in survival and migration of human neural progenitor cells releasing GDNF. Cell Transplant. 17:753–762. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Huebert RC, Vasdev MM, Shergill U, et al: Aquaporin-1 facilitates angiogenic invasion in the pathological neovasculature that accompanies cirrhosis. Hepatology. 52:238–248. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Kirchebner P, Marth C, Mayer I and Daxenbichler G: Metabolism of E1 and E2 in Ishikawa endometrium carcinoma cells: influence of TNFα. J Steroid Biochem Mol Biol. 39:221–222. 1991.PubMed/NCBI

30 

López-Campos JL, Sánchez Silva R, Gómez Izquierdo L, et al: Overexpression of aquaporin-1 in lung adenocarcinomas and pleural mesotheliomas. Histol Histopathol. 26:451–459. 2011.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang XX, Xu KH, Ma JY, Tian YH, Guo XY, Lin J and Wu RJ: Reduced migration of Ishikawa cells associated with downregulation of aquaporin-5. Oncol Lett 4: 257-261, 2012.
APA
Jiang, X.X., Xu, K.H., Ma, J.Y., Tian, Y.H., Guo, X.Y., Lin, J., & Wu, R.J. (2012). Reduced migration of Ishikawa cells associated with downregulation of aquaporin-5. Oncology Letters, 4, 257-261. https://doi.org/10.3892/ol.2012.738
MLA
Jiang, X. X., Xu, K. H., Ma, J. Y., Tian, Y. H., Guo, X. Y., Lin, J., Wu, R. J."Reduced migration of Ishikawa cells associated with downregulation of aquaporin-5". Oncology Letters 4.2 (2012): 257-261.
Chicago
Jiang, X. X., Xu, K. H., Ma, J. Y., Tian, Y. H., Guo, X. Y., Lin, J., Wu, R. J."Reduced migration of Ishikawa cells associated with downregulation of aquaporin-5". Oncology Letters 4, no. 2 (2012): 257-261. https://doi.org/10.3892/ol.2012.738
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang XX, Xu KH, Ma JY, Tian YH, Guo XY, Lin J and Wu RJ: Reduced migration of Ishikawa cells associated with downregulation of aquaporin-5. Oncol Lett 4: 257-261, 2012.
APA
Jiang, X.X., Xu, K.H., Ma, J.Y., Tian, Y.H., Guo, X.Y., Lin, J., & Wu, R.J. (2012). Reduced migration of Ishikawa cells associated with downregulation of aquaporin-5. Oncology Letters, 4, 257-261. https://doi.org/10.3892/ol.2012.738
MLA
Jiang, X. X., Xu, K. H., Ma, J. Y., Tian, Y. H., Guo, X. Y., Lin, J., Wu, R. J."Reduced migration of Ishikawa cells associated with downregulation of aquaporin-5". Oncology Letters 4.2 (2012): 257-261.
Chicago
Jiang, X. X., Xu, K. H., Ma, J. Y., Tian, Y. H., Guo, X. Y., Lin, J., Wu, R. J."Reduced migration of Ishikawa cells associated with downregulation of aquaporin-5". Oncology Letters 4, no. 2 (2012): 257-261. https://doi.org/10.3892/ol.2012.738
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