Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September 2012 Volume 4 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September 2012 Volume 4 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma

  • Authors:
    • Jian Xu
    • Hong Zhu
    • Yaqin Zhao
    • Xin Wang
    • Yali Shen
    • Wu Wang
    • Feng Xu
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China, Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China
  • Pages: 471-476
    |
    Published online on: June 8, 2012
       https://doi.org/10.3892/ol.2012.745
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In the present study, we reviewed 44 postgastrectomy adenocarcinoma patients who had hepatitis B and received treatment in the Abdominal Cancer Department of the West China Hospital between October 2006 and October 2010. Of these patients, 17 developed hepatic dysfunction. Radiotherapy is an independent risk factor to hepatic function on univariate and multivariate analysis. Grade III or IV hepatic dysfunction was developed by five patients, all of whom had received radiotherapy and had reactivated hepatic B virus (HBV). Radiotherapy is a significant risk factor to hepatic function in patients with postgastrectomy adenocarcinoma carrying HBV, thus we suggest excluding the liver from the radiation field. HBV reactivation plays a role in the development of grade III or IV hepatic dysfunction. Patients with reactivated HBV should immediately receive regular antiviral treatment.
View Figures

Figure 1

Figure 2

View References

1 

Cheng JC, Liu MC, Tsai SY, Fang WT, Jer-Min Jian J and Sung JL: Unexpectedly frequent hepatitis B reactivation by chemoradiation in postgastrectomy patients. Cancer. 101:2126–2133. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Stange MA, Tutarel O, Pischke S, Schneider A, Strassburg CP, Becker T, Barg-Hock H, Basturk M, Wursthorn K, Cornberg M, et al: Fulminant hepatic failure due to chemotherapy-induced hepatitis B reactivation: role of rituximab. Z Gastroenterol. 48:258–263. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Lubel JS and Angus PW: Hepatitis B reactivation in patients receiving cytotoxic chemotherapy: diagnosis and management. J Gastroenterol Hepatol. 25:864–871. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Koo YX, Tan DS, Tan IB, Tao M, Chow WC and Lim ST: Hepatitis B virus reactivation and role of antiviral prophylaxis in lymphoma patients with past hepatitis B virus infection who are receiving chemoimmunotherapy. Cancer. 116:115–121. 2010.PubMed/NCBI

5 

Lim SM, Jang JW, Kim BW, Choi H, Choi KY, Park SJ and Han CW: Hepatitis B virus reactivation during chlorambucil and prednisolone treatment in an HBsAg-negative and anti-HBs-positive patient with B-cell chronic lymphocytic leukemia. Korean J Hepatol. 14:213–218. 2008.(In Korean).

6 

Wu JM, Huang YH, Lee PC, Lin HC and Lee SD: Fatal reactivation of hepatitis B virus in a patient who was hepatitis B surface antigen negative and core antibody positive before receiving chemotherapy for non-Hodgkin lymphoma. J Clin Gastroenterol. 43:496–498. 2009. View Article : Google Scholar

7 

Liu CJ, Chen PJ, Chen DS and Kao JH: Hepatitis B virus reactivation in patients receiving cancer chemotherapy: natural history, pathogenesis, and management. Hepatol Int. 14:142011.PubMed/NCBI

8 

Yagci M, Ozkurt ZN, Yegin ZA, Aki Z, Sucak GT and Haznedar R: Hepatitus B virus reactivation in HBV-DNA negative and positive patients with hematological malignancies. Hematology. 15:240–244. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Zhang B, Wang J, Xu W, Wang L and Ni W: Fatal reactivation of occult hepatitis B virus infection after rituximab and chemotherapy in lymphoma: necessity of antiviral prophylaxis. Onkologie. 33:537–539. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Day FL, Karnon J and Rischin D: Cost-effectiveness of universal hepatitis B virus screening in patients beginning chemotherapy for solid tumors. J Clin Oncol. 29:3270–3277. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Cheng JC, Wu JK, Lee PC, Liu HS, Jian JJ, Lin YM, Sung JL and Jan GJ: Biologic susceptibility of hepatocellular carcinoma patients treated with radiotherapy to radiation-induced liver disease. Int J Radiat Oncol Biol Phys. 60:1502–1509. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Evens AM, Jovanovic BD, Su YC, Raisch DW, Ganger D, Belknap SM, Dai MS, Chiu BC, Fintel B, Cheng Y, et al: Rituximab-associated hepatitis B virus (HBV) reactivation in lymphoproliferative diseases: meta-analysis and examination of FDA safety reports. Ann Oncol. 22:1170–1180. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Matsue K, Kimura S, Takanashi Y, Iwama K, Fujiwara H, Yamakura M and Takeuchi M: Reactivation of hepatitis B virus after rituximab-containing treatment in patients with CD20-positive B-cell lymphoma. Cancer. 116:4769–4776. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Niitsu N, Hagiwara Y, Tanae K, Kohri M and Takahashi N: Prospective analysis of hepatitis B virus reactivation in patients with diffuse large B-cell lymphoma after rituximab combination chemotherapy. J Clin Oncol. 28:5097–5100. 2010. View Article : Google Scholar

15 

Minn AY, Hsu A, La T, Kunz P, Fisher GA, Ford JM, Norton JA, Visser B, Goodman KA, Koong AC and Chang DT: Comparison of intensity-modulated radiotherapy and 3-dimensional conformal radiotherapy as adjuvant therapy for gastric cancer. Cancer. 116:3943–3952. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Ji D, Cao J, Hong X, Li J, Wang J, Chen F, Wang C and Zou S: Low incidence of hepatitis B virus reactivation during chemotherapy among diffuse large B-cell lymphoma patients who are HBsAg-negative/HBcAb-positive: a multicenter retrospective study. Eur J Haematol. 85:243–250. 2010. View Article : Google Scholar

17 

Roche B and Samuel D: The difficulties of managing severe hepatitis B virus reactivation. Liver Int. 31(Suppl 1): 104–110. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Artz AS, Somerfield MR, Feld JJ, Giusti AF, Kramer BS, Sabichi AL, Zon RT and Wong SL: American Society of Clinical Oncology provisional clinical opinion: chronic hepatitis B virus infection screening in patients receiving cytotoxic chemotherapy for treatment of malignant diseases. J Clin Oncol. 28:3199–3202. 2010. View Article : Google Scholar

19 

Marinone C and Mestriner M: HBV disease: HBsAg carrier and occult B infection reactivation in haematological setting. Dig Liver Dis. 43(Suppl 1): S49–56. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Chou CH, Chen PJ, Jeng YM, Cheng AL, Huang LR and Cheng JC: Synergistic effect of radiation and interleukin-6 on hepatitis B virus reactivation in liver through STAT3 signaling pathway. Int J Radiat Oncol Biol Phys. 75:1545–1552. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Cheng JC, Liu HS, Wu JK, Chung HW and Jan GJ: Inclusion of biological factors in parallel-architecture normal-tissue complication probability model for radiation-induced liver disease. Int J Radiat Oncol Biol Phys. 62:1150–1156. 2005. View Article : Google Scholar

22 

Kim JH, Park JW, Kim TH, Koh DW, Lee WJ and Kim CM: Hepatitis B virus reactivation after three-dimensional conformal radiotherapy in patients with hepatitis B virus-related hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 69:813–819. 2007. View Article : Google Scholar

23 

Ide Y, Ito Y, Takahashi S, Tokudome N, Kobayashi K, Sugihara T, Hattori M, Yokoyama M, Uchiyama A, Inoue K, et al: Hepatitis B virus reactivation in adjuvant chemotherapy for breast cancer. Breast Cancer. Jul 24–2010.(Epub ahead of print).

24 

Kusumoto S, Tanaka Y, Mizokami M and Ueda R: Clinical significance of hepatitis B virus (HBV)-DNA monitoring to detect HBV reactivation after systemic chemotherapy. J Clin Oncol. 29:e100author reply e101. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Day FL, Link E, Thursky K and Rischin D: Current hepatitis B screening practices and clinical experience of reactivation in patients undergoing chemotherapy for solid tumors: a nationwide survey of medical oncologists. J Oncol Pract. 7:141–147. 2011. View Article : Google Scholar

26 

Huang H, Cai Q, Lin T, Lin X, Liu Y, Gao Y and Peng R: Lamivudine for the prevention of hepatitis B virus reactivation after high-dose chemotherapy and autologous hematopoietic stem cell transplantation for patients with advanced or relapsed non-Hodgkin’s lymphoma single institution experience. Expert Opin Pharmacother. 10:2399–2406. 2009.

27 

You CR, Jang JW, Choi JK, Bae SH, Yoon SK, Kay CS and Choi JY: Hepatic failure caused by reactivation of YMDD mutants occurring during preemptive lamivudine therapy. Gut Liver. 4:262–265. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Colson P, Borentain P, Coso D, Chabannon C, Tamalet C and Gérolami R: Entecavir as a first-line treatment for HBV reactivation following polychemotherapy for lymphoma. Br J Haematol. 143:148–150. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Brost S, Schnitzler P, Stremmel W and Eisenbach C: Entecavir as treatment for reactivation of hepatitis B in immunosuppressed patients. World J Gastroenterol. 16:5447–5451. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Watanabe M, Shibuya A, Takada J, Tanaka Y, Okuwaki Y, Minamino T, Hidaka H, Nakazawa T and Koizumi W: Entecavir is an optional agent to prevent hepatitis B virus (HBV) reactivation: a review of 16 patients. Eur J Intern Med. 21:333–337. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu J, Zhu H, Zhao Y, Wang X, Shen Y, Wang W and Xu F: Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma. Oncol Lett 4: 471-476, 2012.
APA
Xu, J., Zhu, H., Zhao, Y., Wang, X., Shen, Y., Wang, W., & Xu, F. (2012). Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma. Oncology Letters, 4, 471-476. https://doi.org/10.3892/ol.2012.745
MLA
Xu, J., Zhu, H., Zhao, Y., Wang, X., Shen, Y., Wang, W., Xu, F."Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma". Oncology Letters 4.3 (2012): 471-476.
Chicago
Xu, J., Zhu, H., Zhao, Y., Wang, X., Shen, Y., Wang, W., Xu, F."Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma". Oncology Letters 4, no. 3 (2012): 471-476. https://doi.org/10.3892/ol.2012.745
Copy and paste a formatted citation
x
Spandidos Publications style
Xu J, Zhu H, Zhao Y, Wang X, Shen Y, Wang W and Xu F: Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma. Oncol Lett 4: 471-476, 2012.
APA
Xu, J., Zhu, H., Zhao, Y., Wang, X., Shen, Y., Wang, W., & Xu, F. (2012). Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma. Oncology Letters, 4, 471-476. https://doi.org/10.3892/ol.2012.745
MLA
Xu, J., Zhu, H., Zhao, Y., Wang, X., Shen, Y., Wang, W., Xu, F."Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma". Oncology Letters 4.3 (2012): 471-476.
Chicago
Xu, J., Zhu, H., Zhao, Y., Wang, X., Shen, Y., Wang, W., Xu, F."Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma". Oncology Letters 4, no. 3 (2012): 471-476. https://doi.org/10.3892/ol.2012.745
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team