Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma

  • Authors:
    • Jian Xu
    • Hong Zhu
    • Yaqin Zhao
    • Xin Wang
    • Yali Shen
    • Wu Wang
    • Feng Xu
  • View Affiliations

  • Published online on: June 8, 2012     https://doi.org/10.3892/ol.2012.745
  • Pages: 471-476
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Abstract

In the present study, we reviewed 44 postgastrectomy adenocarcinoma patients who had hepatitis B and received treatment in the Abdominal Cancer Department of the West China Hospital between October 2006 and October 2010. Of these patients, 17 developed hepatic dysfunction. Radiotherapy is an independent risk factor to hepatic function on univariate and multivariate analysis. Grade III or IV hepatic dysfunction was developed by five patients, all of whom had received radiotherapy and had reactivated hepatic B virus (HBV). Radiotherapy is a significant risk factor to hepatic function in patients with postgastrectomy adenocarcinoma carrying HBV, thus we suggest excluding the liver from the radiation field. HBV reactivation plays a role in the development of grade III or IV hepatic dysfunction. Patients with reactivated HBV should immediately receive regular antiviral treatment.
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September 2012
Volume 4 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Xu J, Zhu H, Zhao Y, Wang X, Shen Y, Wang W and Xu F: Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma. Oncol Lett 4: 471-476, 2012
APA
Xu, J., Zhu, H., Zhao, Y., Wang, X., Shen, Y., Wang, W., & Xu, F. (2012). Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma. Oncology Letters, 4, 471-476. https://doi.org/10.3892/ol.2012.745
MLA
Xu, J., Zhu, H., Zhao, Y., Wang, X., Shen, Y., Wang, W., Xu, F."Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma". Oncology Letters 4.3 (2012): 471-476.
Chicago
Xu, J., Zhu, H., Zhao, Y., Wang, X., Shen, Y., Wang, W., Xu, F."Factors associated with hepatic dysfunction in hepatitis B-positive patients with postgastrectomy adenocarcinoma". Oncology Letters 4, no. 3 (2012): 471-476. https://doi.org/10.3892/ol.2012.745