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September 2012 Volume 4 Issue 3

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Central nervous system involvement in adult patients with diffuse large B-cell lymphoma: Influence of rituximab

  • Authors:
    • Bing Cao
    • Xiaoyan Zhou
    • Dongmei Ji
    • Junning Cao
    • Ye Guo
    • Qunling Zhang
    • Xianghua Wu
    • Junmin Li
    • Jianmin Wang
    • Fangyuan Chen
    • Chun Wang
    • Shanhua Zou
    • Xiaonan Hong
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, P.R. China, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, P.R. China, Department of Hematology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China , Department of Hematology, Changhai Hospital Affiliated to Second Military Medical University, Shanghai, P.R. China, Department of Hematology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China , Department of Hematology, The First People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, P.R. China , Department of Hematology, Zhongshan Hospital Fudan University, Shanghai, P.R. China
  • Pages: 541-545
    |
    Published online on: June 13, 2012
       https://doi.org/10.3892/ol.2012.755
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Abstract

CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone)-like chemotherapy, in combination with rituximab (R-CHOP-like), improves outcome in patients with diffuse large B-cell lymphoma (DLBCL). We aimed to investigate the impact of rituximab on central nervous system (CNS) disease in adult patients. We studied 315 patients (aged 18-60 years old) from six hospitals between July 2003 and May 2008. All patients received CHOP-like (n=165) or R-CHOP-like (n=150) regimen every 3 weeks. With a median follow-up of 3.69 years, 10 patients (3.17%) developed CNS disease. The cumulative risk of CNS occurrence was not significantly different between the two treatment groups (P=0.871). We conclude that the addition of rituximab did not reduce the risk of CNS disease in adult patients with DLBCL.
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Copy and paste a formatted citation
Spandidos Publications style
Cao B, Zhou X, Ji D, Cao J, Guo Y, Zhang Q, Wu X, Li J, Wang J, Chen F, Chen F, et al: Central nervous system involvement in adult patients with diffuse large B-cell lymphoma: Influence of rituximab. Oncol Lett 4: 541-545, 2012.
APA
Cao, B., Zhou, X., Ji, D., Cao, J., Guo, Y., Zhang, Q. ... Hong, X. (2012). Central nervous system involvement in adult patients with diffuse large B-cell lymphoma: Influence of rituximab. Oncology Letters, 4, 541-545. https://doi.org/10.3892/ol.2012.755
MLA
Cao, B., Zhou, X., Ji, D., Cao, J., Guo, Y., Zhang, Q., Wu, X., Li, J., Wang, J., Chen, F., Wang, C., Zou, S., Hong, X."Central nervous system involvement in adult patients with diffuse large B-cell lymphoma: Influence of rituximab". Oncology Letters 4.3 (2012): 541-545.
Chicago
Cao, B., Zhou, X., Ji, D., Cao, J., Guo, Y., Zhang, Q., Wu, X., Li, J., Wang, J., Chen, F., Wang, C., Zou, S., Hong, X."Central nervous system involvement in adult patients with diffuse large B-cell lymphoma: Influence of rituximab". Oncology Letters 4, no. 3 (2012): 541-545. https://doi.org/10.3892/ol.2012.755
Copy and paste a formatted citation
x
Spandidos Publications style
Cao B, Zhou X, Ji D, Cao J, Guo Y, Zhang Q, Wu X, Li J, Wang J, Chen F, Chen F, et al: Central nervous system involvement in adult patients with diffuse large B-cell lymphoma: Influence of rituximab. Oncol Lett 4: 541-545, 2012.
APA
Cao, B., Zhou, X., Ji, D., Cao, J., Guo, Y., Zhang, Q. ... Hong, X. (2012). Central nervous system involvement in adult patients with diffuse large B-cell lymphoma: Influence of rituximab. Oncology Letters, 4, 541-545. https://doi.org/10.3892/ol.2012.755
MLA
Cao, B., Zhou, X., Ji, D., Cao, J., Guo, Y., Zhang, Q., Wu, X., Li, J., Wang, J., Chen, F., Wang, C., Zou, S., Hong, X."Central nervous system involvement in adult patients with diffuse large B-cell lymphoma: Influence of rituximab". Oncology Letters 4.3 (2012): 541-545.
Chicago
Cao, B., Zhou, X., Ji, D., Cao, J., Guo, Y., Zhang, Q., Wu, X., Li, J., Wang, J., Chen, F., Wang, C., Zou, S., Hong, X."Central nervous system involvement in adult patients with diffuse large B-cell lymphoma: Influence of rituximab". Oncology Letters 4, no. 3 (2012): 541-545. https://doi.org/10.3892/ol.2012.755
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