Central nervous system involvement in adult patients with diffuse large B-cell lymphoma: Influence of rituximab

  • Authors:
    • Bing Cao
    • Xiaoyan Zhou
    • Dongmei Ji
    • Junning Cao
    • Ye Guo
    • Qunling Zhang
    • Xianghua Wu
    • Junmin Li
    • Jianmin Wang
    • Fangyuan Chen
    • Chun Wang
    • Shanhua Zou
    • Xiaonan Hong
  • View Affiliations

  • Published online on: June 13, 2012     https://doi.org/10.3892/ol.2012.755
  • Pages: 541-545
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Abstract

CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone)-like chemotherapy, in combination with rituximab (R-CHOP-like), improves outcome in patients with diffuse large B-cell lymphoma (DLBCL). We aimed to investigate the impact of rituximab on central nervous system (CNS) disease in adult patients. We studied 315 patients (aged 18-60 years old) from six hospitals between July 2003 and May 2008. All patients received CHOP-like (n=165) or R-CHOP-like (n=150) regimen every 3 weeks. With a median follow-up of 3.69 years, 10 patients (3.17%) developed CNS disease. The cumulative risk of CNS occurrence was not significantly different between the two treatment groups (P=0.871). We conclude that the addition of rituximab did not reduce the risk of CNS disease in adult patients with DLBCL.
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September 2012
Volume 4 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Cao B, Zhou X, Ji D, Cao J, Guo Y, Zhang Q, Wu X, Li J, Wang J, Chen F, Chen F, et al: Central nervous system involvement in adult patients with diffuse large B-cell lymphoma: Influence of rituximab. Oncol Lett 4: 541-545, 2012
APA
Cao, B., Zhou, X., Ji, D., Cao, J., Guo, Y., Zhang, Q. ... Hong, X. (2012). Central nervous system involvement in adult patients with diffuse large B-cell lymphoma: Influence of rituximab. Oncology Letters, 4, 541-545. https://doi.org/10.3892/ol.2012.755
MLA
Cao, B., Zhou, X., Ji, D., Cao, J., Guo, Y., Zhang, Q., Wu, X., Li, J., Wang, J., Chen, F., Wang, C., Zou, S., Hong, X."Central nervous system involvement in adult patients with diffuse large B-cell lymphoma: Influence of rituximab". Oncology Letters 4.3 (2012): 541-545.
Chicago
Cao, B., Zhou, X., Ji, D., Cao, J., Guo, Y., Zhang, Q., Wu, X., Li, J., Wang, J., Chen, F., Wang, C., Zou, S., Hong, X."Central nervous system involvement in adult patients with diffuse large B-cell lymphoma: Influence of rituximab". Oncology Letters 4, no. 3 (2012): 541-545. https://doi.org/10.3892/ol.2012.755