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September 2012 Volume 4 Issue 3

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Article

Mesenchymal stem cell-like cells in classic renal angiomyolipoma

  • Authors:
    • Xinlong Yan
    • Lixin Shi
    • Guangfu Chen
    • Xu Zhang
    • Bing Liu
    • Wen Yue
    • Xuetao Pei
    • Shengkun Sun
  • View Affiliations / Copyright

    Affiliations: Stem Cells and Regenerative Medicine Laboratory, Institute of Beijing Transfusion Medicine, Beijing 100850, P.R. China , Department of Urology, PLA General Hospital, Beijing 100853, P.R. China, Department of Tumor Molecular Biology, Affiliated Hospital to the Academy of Medical Sciences, Beijing 100071, P.R. China
  • Pages: 398-402
    |
    Published online on: June 14, 2012
       https://doi.org/10.3892/ol.2012.760
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Abstract

As a benign mesenchymal tumor, classic renal angiomyolipoma (AML) may obliterate the kidney parenchyma and cause renal hemorrhage. It has previously been reported that mesenchymal stem cells (MSCs) are involved in tumorigenesis; however, there have been no studies on stem cells with renal AML origin. In the present study, six females with classic renal AML received a partial or total nephrectomy. During surgery, tumor tissues were collected and culture expansion of adhesive fibroblastoid cells from these tissues was performed. We successfully isolated and cultured MSC‑like cells from all six renal AML tumors. MSC characteristics, including morphology, immunophenotype and multidifferentiation potential were analyzed. Flow cytometry analysis revealed that these cells are highly similar to human bone marrow MSCs due to the expression of MSC‑specific surface proteins, including CD29, CD44, CD73, CD90 and CD105. The stem cell‑like nature of these cells is further supported by their adipogenic and osteogenic differentiation potentials when incubated in appropriate differentiation cocktails. Renal AML‑derived adhesive cells possessing the characteristics of MSCs are described for the first time. They are a novel cell type which may be useful in future studies with regards to determining the role of stem cells in the formation and development of renal AML.
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Copy and paste a formatted citation
Spandidos Publications style
Yan X, Shi L, Chen G, Zhang X, Liu B, Yue W, Pei X and Sun S: Mesenchymal stem cell-like cells in classic renal angiomyolipoma. Oncol Lett 4: 398-402, 2012.
APA
Yan, X., Shi, L., Chen, G., Zhang, X., Liu, B., Yue, W. ... Sun, S. (2012). Mesenchymal stem cell-like cells in classic renal angiomyolipoma. Oncology Letters, 4, 398-402. https://doi.org/10.3892/ol.2012.760
MLA
Yan, X., Shi, L., Chen, G., Zhang, X., Liu, B., Yue, W., Pei, X., Sun, S."Mesenchymal stem cell-like cells in classic renal angiomyolipoma". Oncology Letters 4.3 (2012): 398-402.
Chicago
Yan, X., Shi, L., Chen, G., Zhang, X., Liu, B., Yue, W., Pei, X., Sun, S."Mesenchymal stem cell-like cells in classic renal angiomyolipoma". Oncology Letters 4, no. 3 (2012): 398-402. https://doi.org/10.3892/ol.2012.760
Copy and paste a formatted citation
x
Spandidos Publications style
Yan X, Shi L, Chen G, Zhang X, Liu B, Yue W, Pei X and Sun S: Mesenchymal stem cell-like cells in classic renal angiomyolipoma. Oncol Lett 4: 398-402, 2012.
APA
Yan, X., Shi, L., Chen, G., Zhang, X., Liu, B., Yue, W. ... Sun, S. (2012). Mesenchymal stem cell-like cells in classic renal angiomyolipoma. Oncology Letters, 4, 398-402. https://doi.org/10.3892/ol.2012.760
MLA
Yan, X., Shi, L., Chen, G., Zhang, X., Liu, B., Yue, W., Pei, X., Sun, S."Mesenchymal stem cell-like cells in classic renal angiomyolipoma". Oncology Letters 4.3 (2012): 398-402.
Chicago
Yan, X., Shi, L., Chen, G., Zhang, X., Liu, B., Yue, W., Pei, X., Sun, S."Mesenchymal stem cell-like cells in classic renal angiomyolipoma". Oncology Letters 4, no. 3 (2012): 398-402. https://doi.org/10.3892/ol.2012.760
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