Volume doubling time of lung cancers detected in a chest radiograph mass screening program: Comparison with CT screening

Kanashiki,Maki; Tomizawa,Takuji; Yamaguchi,Iwao; Kurishima,Koichi; Hizawa,Nobuyuki; Ishikawa,Hiroichi; Kagohashi,Katsunori; Satoh,Hiroaki

doi:10.3892/ol.2012.780

Volume doubling time of lung cancers detected in a chest radiograph mass screening program: Comparison with CT screening

Authors:
- Maki Kanashiki
- Takuji Tomizawa
- Iwao Yamaguchi
- Koichi Kurishima
- Nobuyuki Hizawa
- Hiroichi Ishikawa
- Katsunori Kagohashi
- Hiroaki Satoh
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Affiliations: Ibaraki Health Service Association, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan, Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan, Division of Respiratory Medicine, Tsukuba Medical Center, Tsukuba, Japan, Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Tsukuba, Japan
Published online on: June 28, 2012 https://doi.org/10.3892/ol.2012.780
Pages: 513-516

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Abstract

The aim of this study was to evaluate the volume doubling time (VDT) of lung cancer detected in our annual chest radiograph screening program and to compare it with those previously reported for computed tomography (CT) screening. In total, 209 patients who had a measurable tumor shadow and a history of participating in our chest radiograph mass screening program between 2006 and 2009 were included in this study. Indirect roentgenograms for patients with lung cancer were converted into digital images, and the section showing the tumor was enlarged on the monitor to a size of 0.01 mm. The mean VDT for all the patients was 158 days. Only 3.8% of the patients had a VDT of more than 400 days. In 140 patients with adenocarcinoma, the mean VDT was 177 days, and 5.0% of these patients had a VDT of more than 400 days. In the 44 patients with squamous cell carcinoma, the mean VDT was 133 days, and only 2.3% of these patients had a VDT of more than 400 days. These results were different from those previously reported for CT screening. In several reports on CT screening, more than 20% of the lung cancers had VDTs of more than 400 days. Since it is common knowledge that there are ‘indolent’ lung cancers with a VDT of more than 400 days, screening by annual chest radiography with rare overdiagnosis may need to be reconsidered.

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1	Spratt JS and Spratt JA: The prognostic value of measuring the gross linear radial growth of pulmonary metastases and primary pulmonary cancers. J Thorac Cardiovasc Surg. 71:274–278. 1976.PubMed/NCBI
2	Hasegawa M, Sone S, Takashima S, et al: Growth rate of small lung cancers detected on mass CT screening. Br J Radiol. 73:1252–1259. 2000. View Article : Google Scholar : PubMed/NCBI
3	Lindell RM, Hartman TE, Swensen SJ, et al: Five-year lung cancer screening experience: CT appearance, growth rate, location, and histologic features of 61 lung cancers. Radiology. 242:555–562. 2007.PubMed/NCBI
4	Honda O, Johkoh T, Sekiguchi J, et al: Doubling time of lung cancer determined using three-dimensional volumetric software: comparison of squamous cell carcinoma and adenocarcinoma. Lung Cancer. 66:211–217. 2009.
5	Sone S, Matsumoto T, Honda T, et al: HRCT futures of small peripheral lung carcinomas detected in a low-dose CT screening program. Acad Radiol. 17:75–83. 2010. View Article : Google Scholar : PubMed/NCBI
6	Oda S, Awai K, Murao K, et al: Volume-doubling time of pulmonary nodules with ground glass opacity at multidetector CT: assessment with computer-aided three-dimensional volumetry. Acad Radiol. 18:63–69. 2011.PubMed/NCBI
7	Dhopeshwarkar MR, Roberts HC, Paul NS, Dong Z, Tsao M and Menezes RJ: Screen-detected lung cancer: a retrospective analysis of CT appearance. Acad Radiol. 18:1270–1276. 2011. View Article : Google Scholar : PubMed/NCBI
8	Yankelevitz DF and Henschke CI: Does 2-year stability imply that pulmonary nodules are benign? AJR. 168:325–328. 1997.PubMed/NCBI
9	Schwartz M: A biomathematical approach to clinical tumor growth. Cancer. 14:1272–1294. 1961. View Article : Google Scholar : PubMed/NCBI
10	Usuda K, Saito Y, Sagawa M, et al: Tumor doubling time prognostic assessment of patients with primary lung cancer. Cancer. 74:2239–2244. 1994. View Article : Google Scholar : PubMed/NCBI
11	Lillington GA: Management of solitary pulmonary nodules. Dis Mon. 37:271–318. 1991. View Article : Google Scholar : PubMed/NCBI
12	Viggiano RW, Swensen SJ and Rosenow EC III: Evaluation and management of solitary and multiple pulmonary nodules. Clin Chest Med. 13:83–95. 1992.PubMed/NCBI
13	Cummings SR, Lillington GA and Richard RJ: Estimating the probability of malignancy in solitary pulmonary nodules. A Bayesian approach. Am Rev Respir Dis. 134:449–452. 1986.PubMed/NCBI
14	Xu DM, Gietema H, de Koning HJ, et al: Nodule management protocol of the NELSON randomized lung cancer screening trial. Lung Cancer. 54:177–184. 2006. View Article : Google Scholar : PubMed/NCBI
15	Xu DM, van der Zaag-Loonen HJ, Oudkerk M, et al: Smooth or attached solid indeterminate nodules detected at baseline CT screening in the NELSON study: cancer risk during 1 year of follow-up. Radiology. 250:264–272. 2009.PubMed/NCBI
16	Yankelevitz DF, Kostis WJ, Henschke CI, et al: Overdiagnosis in chest radiographic screening for lung carcinoma: frequency. Cancer. 97:1271–1275. 2003. View Article : Google Scholar : PubMed/NCBI
17	Fujimura S, Suda S, Yamauchi A, et al: Tumor doubling time and PPD skin test reactivity in resectable lung cancer. J Jpn Lung Cancer Soc. 19:135–142. 1979. View Article : Google Scholar
18	Satoh H, Ishikawa H, Yamashita YT, et al: Outcome of patients with lung cancer detected by mass screening versus presentation with symptoms. Anticancer Res. 17:2293–2296. 1997.PubMed/NCBI
19	Hayabuchi N, Russell WJ and Murakami J: Slow-growing lung cancer in a fixed population sample: radiologic assessments. Cancer. 52:1098–1104. 1983. View Article : Google Scholar : PubMed/NCBI
20	Awai K, Fujikawa K, Nakamura S, et al: Serial changes in CT findings of small peripheral pulmonary adenocarcinomas followed up for more than one year. Jpn J Lung Cancer. 38:19–28. 1998.
21	Geddes DM: The natural history of lung cancer: a review based on rates of tumour growth. Br J Dis Chest. 73:l-171979. View Article : Google Scholar : PubMed/NCBI
22	Filderman AE, Shaw C and Matthay RA: Lung cancer: Part I. Etiology, pathology, natural history, manifestations, and diagnostic techniques. Invest Radiol. 21:230–239. 1986. View Article : Google Scholar : PubMed/NCBI