MACC1: A potential molecule associated with pancreatic cancer metastasis and chemoresistance

A JemalR SiegelJ XuE WardCancer statisticsCA Cancer J Clin602773002010

A JemalF BrayMM CenterJ FerlayE WardD FormanGlobal cancer statisticsCA Cancer J Clin616990201110.3322/caac.20107

K PliarchopoulouD PectasidesPancreatic cancer: Current and future treatment strategiesCancer Treat Rev35431436200910.1016/j.ctrv.2009.02.00519328630

A MaitraRH HrubanPancreatic cancerAnnu Rev Pathol3157188200810.1146/annurev.pathmechdis.3.121806.154305

J ShenMD PersonJ ZhuJL AbbruzzeseD LiProtein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometryCancer Res6490189026200410.1158/0008-5472.CAN-04-3262

U SteinW WaltherF ArltMACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasisNat Med155967200910.1038/nm.188919098908

F ArltU SteinColon cancer metastasis: MACC1 and Met as metastatic pacemakersInt J Biochem Cell Biol4123562359200910.1016/j.biocel.2009.08.00119666136

A ShirahataK ShinmuraY KitamuraMACC1 as a marker for advanced colorectal carcinomaAnticancer Res3026892692201020682999

A ShirahataW FanK SakurabaMACC 1 as a marker for vascular invasive hepatocellular carcinomaAnticancer Res31777780201121498695

G ChundongH UramotoT OnitsukaMolecular diagnosis of MACC1 status in lung adenocarcinoma by immunohistochemical analysisAnticancer Res3111411145201121508357

H ShimokawaH UramotoT OnitsukaOverexpression of MACC1 mRNA in lung adenocarcinoma is associated with postoperative recurrenceJ Thorac Cardiovasc Surg141895898201110.1016/j.jtcvs.2010.09.04421093878

A ShirahataM SakataY KitamuraMACC 1 as a marker for peritoneal-disseminated gastric carcinomaAnticancer Res3034413444201020944120

LH SobinWC WittekindTNM Classification of Malignant Tumours (UICC)6th editionWiley-LissNew York93962002

DG AltmanB LausenW SauerbreiM SchumacherDangers of using ‘optimal’ cutpoints in the evaluation of prognostic factorsJ Natl Cancer Inst868298351994

A ArltA GehrzS MuerkosterRole of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell deathOncogene2232433251200310.1038/sj.onc.120639012761494

J QiuP HuangQ LiuIdentification of MACC1 as a novel prognostic marker in hepatocellular carcinomaJ Transl Med9166201110.1186/1479-5876-9-16621955323

R ZhangH ShiZ ChenQ WuF RenH HuangEffects of metastasis-associated in colon cancer 1 inhibition by small hairpin RNA on ovarian carcinoma OVCAR-3 cellsJ Exp Clin Cancer Res3083201110.1186/1756-9966-30-8321923915

D ShookR KellerMechanisms, mechanics and function of epithelial-mesenchymal transitions in early developmentMech Dev12013511383200310.1016/j.mod.2003.06.00514623443

J YangRA WeinbergEpithelial-mesenchymal transition: at the crossroads of development and tumor metastasisDev Cell14818829200810.1016/j.devcel.2008.05.00918539112

AN ShahJM SummyJ ZhangSI ParkNU ParikhGE GallickDevelopment and characterization of gemcitabine-resistant pancreatic tumor cellsAnn Surg Oncol1436293637200710.1245/s10434-007-9583-517909916

Z WangY LiD KongAcquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathwayCancer Res6924002407200910.1158/0008-5472.CAN-08-4312

T ArumugamV RamachandranKF FournierEpithelial to mesenchymal transition contributes to drug resistance in pancreatic cancerCancer Res6958205828200910.1158/0008-5472.CAN-08-281919584296

JL BosRas oncogenes in human cancer: a reviewCancer Res494682468919892547513

F CalvoL Agudo-IbanezP CrespoThe Ras-ERK pathway: understanding site-specific signaling provides hope of new anti-tumor therapiesBioessays32412421201010.1002/bies.20090015520414899

T DeramaudtAK RustgiMutant KRAS in the initiation of pancreatic cancerBiochim Biophys Acta175697101200516169155

S RejibaS WackM AprahamianA HajriK-ras oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatmentCancer Sci9811281136200710.1111/j.1349-7006.2007.00506.x

K NishidaT HiranoThe role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptorsCancer Sci9410291033200310.1111/j.1349-7006.2003.tb01396.x14662016

H GuBG NeelThe ‘Gab’ in signal transductionTrends Cell Biol131221302003

A YartM LaffargueP MayeuxA critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factorJ Biol Chem27688568864200110.1074/jbc.M00696620011134009

JM CunnickS MengY RenRegulation of the mitogen-activated protein kinase signaling pathway by SHP2J Biol Chem27794989504200210.1074/jbc.M11054720011779868