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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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October 2012 Volume 4 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Article

Protracted low doses of temozolomide for the treatment of patients with recurrent glioblastoma: A phase II study

  • Authors:
    • Matteo Santoni
    • Alessandro Paccapelo
    • Luciano Burattini
    • Maristella Bianconi
    • Massimo Cardinali
    • Letizia Fabbietti
    • Roberto Trignani
    • Franco Rychlicki
    • Stefano Cascinu

  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Polytechnic University of the Marche Region, 60126 Torrette, Ancona, Italy, Radiotherapy Unit, Polytechnic University of the Marche Region, 60126 Torrette, Ancona, Italy, Division of Neurosurgery, Polytechnic University of the Marche Region, 60126 Torrette, Ancona, Italy
  • Pages: 799-801
    |
    Published online on: July 5, 2012
       https://doi.org/10.3892/ol.2012.788
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Abstract

O6-alkylguanine‑DNA alkyltransferase (AGAT), involved in temozolomide‑induced DNA damage repair, plays a key role in the efficacy of temozolomide. AGAT activity may be reduced by protracted temozolomide doses. On the basis of the preclinical findings, we treated patients with a histologically‑proven diagnosis of glioblastoma (GBM) following adjuvant temozolomide failure with a low protracted dose of temozolomide (130 mg/m2/day, days 1‑7 and 15‑21, every 4 weeks). The primary endpoint of the study was 6‑month progression‑free survival (PFS‑6 m). The secondary endpoints were overall survival (OS) from the start of temozolomide alternative schedule and toxicity. Enrolment was ceased at 27 patients due to the lack of effectiveness of this regimen. Results indicate that our schedule is well‑tolerated, but ineffective in patients with GBM and further strategies are required to improve the outcome of these patients.
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1. 

DA ReardonJN RichHS FriedmanDD BignerRecent advances in the treatment of malignant astrocytomaJ Clin Oncol2412531265200610.1200/JCO.2005.04.530216525180

2. 

BJ DennyRT WheelhouseMF StevensLL TsangJA SlackNMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNABiochemistry3390459051199410.1021/bi00197a0038049205

3. 

J ZhangMF StevensCA LaughtonS MadhusudanTD BradshawAcquired resistance to temozolomide in glioma cell lines: molecular mechanisms and potential translational applicationsOncology78103114201010.1159/00030613920357518

4. 

MJ RiemenschneiderME HegiG ReifenbergerMGMT promoter methylation in malignant gliomasTarget Oncol5161165201010.1007/s11523-010-0153-620725792

5. 

AW TolcherSL GersonL DenisMarked inactivation of O6-alkylguanine-DNA alkyltransferase activity with protracted temozolomide schedulesBr J Cancer8810041011200310.1038/sj.bjc.660082712671695

6. 

AA BrandesA TosoniG CavalloTemozolomide 3 weeks on and 1 week off as first-line therapy for recurrent glioblastoma: phase II study from gruppo italiano cooperativo di neuro-oncologia (GICNO)Br J Cancer9511551160200610.1038/sj.bjc.660337617024124

7. 

R StuppWP MasonMJ van den BentRadiotherapy plus concomitant and adjuvant temozolomide for glioblastomaN Engl J Med352987996200510.1056/NEJMoa04333015758009

8. 

E KaplanP MeierNon parametric estimation from incomplete observationsJ Am Stat Assoc53457481195810.1080/01621459.1958.10501452

9. 

DR MacdonaldTL CascinoSC Schold JrJG CairncrossResponse criteria for phase II studies of supratentorial malignant gliomaJ Clin Oncol81277128019902358840

10. 

A WickJ FelsbergJP SteinbachEfficacy and tolerability of temozolomide in an alternating weekly regimen in patients with recurrent gliomaJ Clin Oncol2533573361200710.1200/JCO.2007.10.772217664483

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Copy and paste a formatted citation
Spandidos Publications style
Santoni M, Paccapelo A, Burattini L, Bianconi M, Cardinali M, Fabbietti L, Trignani R, Rychlicki F and Cascinu S: Protracted low doses of temozolomide for the treatment of patients with recurrent glioblastoma: A phase II study. Oncol Lett 4: 799-801, 2012.
APA
Santoni, M., Paccapelo, A., Burattini, L., Bianconi, M., Cardinali, M., Fabbietti, L. ... Cascinu, S. (2012). Protracted low doses of temozolomide for the treatment of patients with recurrent glioblastoma: A phase II study. Oncology Letters, 4, 799-801. https://doi.org/10.3892/ol.2012.788
MLA
Santoni, M., Paccapelo, A., Burattini, L., Bianconi, M., Cardinali, M., Fabbietti, L., Trignani, R., Rychlicki, F., Cascinu, S."Protracted low doses of temozolomide for the treatment of patients with recurrent glioblastoma: A phase II study". Oncology Letters 4.4 (2012): 799-801.
Chicago
Santoni, M., Paccapelo, A., Burattini, L., Bianconi, M., Cardinali, M., Fabbietti, L., Trignani, R., Rychlicki, F., Cascinu, S."Protracted low doses of temozolomide for the treatment of patients with recurrent glioblastoma: A phase II study". Oncology Letters 4, no. 4 (2012): 799-801. https://doi.org/10.3892/ol.2012.788
Copy and paste a formatted citation
x
Spandidos Publications style
Santoni M, Paccapelo A, Burattini L, Bianconi M, Cardinali M, Fabbietti L, Trignani R, Rychlicki F and Cascinu S: Protracted low doses of temozolomide for the treatment of patients with recurrent glioblastoma: A phase II study. Oncol Lett 4: 799-801, 2012.
APA
Santoni, M., Paccapelo, A., Burattini, L., Bianconi, M., Cardinali, M., Fabbietti, L. ... Cascinu, S. (2012). Protracted low doses of temozolomide for the treatment of patients with recurrent glioblastoma: A phase II study. Oncology Letters, 4, 799-801. https://doi.org/10.3892/ol.2012.788
MLA
Santoni, M., Paccapelo, A., Burattini, L., Bianconi, M., Cardinali, M., Fabbietti, L., Trignani, R., Rychlicki, F., Cascinu, S."Protracted low doses of temozolomide for the treatment of patients with recurrent glioblastoma: A phase II study". Oncology Letters 4.4 (2012): 799-801.
Chicago
Santoni, M., Paccapelo, A., Burattini, L., Bianconi, M., Cardinali, M., Fabbietti, L., Trignani, R., Rychlicki, F., Cascinu, S."Protracted low doses of temozolomide for the treatment of patients with recurrent glioblastoma: A phase II study". Oncology Letters 4, no. 4 (2012): 799-801. https://doi.org/10.3892/ol.2012.788
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