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Article

Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis

  • Authors:
    • Zhengguang Li
    • Jun Wu
    • Changping Wu
    • Jingting Jiang
    • Xiao Zheng
    • Bin Xu
    • Min Li
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, P.R. China
  • Pages: 677-681
    |
    Published online on: July 6, 2012
       https://doi.org/10.3892/ol.2012.790
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Abstract

Deguelin is a naturally occurring rotenoid with strong cancer chemopreventive and antitumor activities. In the present study, we investigated the antitumor activity of deguelin against MPC-11 murine myeloma cells and the possible mechanism of action in vitro. Our results revealed that deguelin inhibited the proliferation of MPC-11 cells in a concentration- and time-dependent manner and caused the apoptotic death of MPC-11 cells. Following exposure to deguelin, the phosphorylation of Akt was decreased. The inhibition of cell growth may be associated with decreased levels of phosphorylated Akt. Deguelin-induced apoptosis was characterized by the upregulation of Bax, downregulation of Bcl-2 and activation of caspase-3. In conclusion, deguelin inhibits murine myeloma cell proliferation by inducing apoptosis via regulation of the Bax/Bcl-2 ratio and by inhibition of the activation of Akt. Its potential as an anticancer agent against multiple myeloma warrants further investigation.
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Copy and paste a formatted citation
Spandidos Publications style
Li Z, Wu J, Wu C, Jiang J, Zheng X, Xu B and Li M: Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis. Oncol Lett 4: 677-681, 2012.
APA
Li, Z., Wu, J., Wu, C., Jiang, J., Zheng, X., Xu, B., & Li, M. (2012). Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis. Oncology Letters, 4, 677-681. https://doi.org/10.3892/ol.2012.790
MLA
Li, Z., Wu, J., Wu, C., Jiang, J., Zheng, X., Xu, B., Li, M."Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis". Oncology Letters 4.4 (2012): 677-681.
Chicago
Li, Z., Wu, J., Wu, C., Jiang, J., Zheng, X., Xu, B., Li, M."Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis". Oncology Letters 4, no. 4 (2012): 677-681. https://doi.org/10.3892/ol.2012.790
Copy and paste a formatted citation
x
Spandidos Publications style
Li Z, Wu J, Wu C, Jiang J, Zheng X, Xu B and Li M: Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis. Oncol Lett 4: 677-681, 2012.
APA
Li, Z., Wu, J., Wu, C., Jiang, J., Zheng, X., Xu, B., & Li, M. (2012). Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis. Oncology Letters, 4, 677-681. https://doi.org/10.3892/ol.2012.790
MLA
Li, Z., Wu, J., Wu, C., Jiang, J., Zheng, X., Xu, B., Li, M."Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis". Oncology Letters 4.4 (2012): 677-681.
Chicago
Li, Z., Wu, J., Wu, C., Jiang, J., Zheng, X., Xu, B., Li, M."Deguelin, a natural rotenoid, inhibits mouse myeloma cell growth in vitro via induction of apoptosis". Oncology Letters 4, no. 4 (2012): 677-681. https://doi.org/10.3892/ol.2012.790
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