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Article

Pien Tze Huang inhibits the proliferation of human colon carcinoma cells by arresting G1/S cell cycle progression

  • Authors:
    • Aling Shen
    • Fei Hong
    • Liya Liu
    • Jiumao Lin
    • Lihui  Wei
    • Qiaoyan  Cai
    • Zhenfeng Hong
    • Jun Peng
  • View Affiliations / Copyright

    Affiliations: Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China, Postdoctor Workstation, Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd., Shangjie, Zhangzhou, Fujian 363000, P.R. China, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China
  • Pages: 767-770
    |
    Published online on: July 19, 2012
       https://doi.org/10.3892/ol.2012.811
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Abstract

Pien Tze Huang (PZH), a well-known traditional Chinese formula prescribed 450 years ago in the Ming Dynasty, has been used in China and Southeast Asia for centuries as a folk remedy for various types of cancer, including colorectal cancer (CRC). Recently, we reported that PZH is capable of inhibiting colon cancer growth both in vivo and in vitro via the promotion of apoptosis and inhibition of tumor angiogenesis. To elucidate the mechanism of the tumoricidal activity of PZH, its effect on the proliferation of human colon carcinoma Caco-2 cells was evaluated and the underlying molecular mechanism was investigated. Results showed that PZH inhibited Caco-2 cell viability and survival in a dose‑ and/or time-dependent manner. In addition, PZH treatment was found to block the G1/S cell cycle progression. Moreover, PZH suppressed the mRNA and protein expression of pro‑proliferative Cyclin D1 and CDK4. Findings of the present study suggest that inhibition of cell proliferation via the G1/S cell cycle arrest is a potential mechanism by which PZH can be effective in the treatment of cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Shen A, Hong F, Liu L, Lin J, Wei L, Cai Q, Hong Z and Peng J: Pien Tze Huang inhibits the proliferation of human colon carcinoma cells by arresting G1/S cell cycle progression. Oncol Lett 4: 767-770, 2012.
APA
Shen, A., Hong, F., Liu, L., Lin, J., Wei, L., Cai, Q. ... Peng, J. (2012). Pien Tze Huang inhibits the proliferation of human colon carcinoma cells by arresting G1/S cell cycle progression. Oncology Letters, 4, 767-770. https://doi.org/10.3892/ol.2012.811
MLA
Shen, A., Hong, F., Liu, L., Lin, J., Wei, L., Cai, Q., Hong, Z., Peng, J."Pien Tze Huang inhibits the proliferation of human colon carcinoma cells by arresting G1/S cell cycle progression". Oncology Letters 4.4 (2012): 767-770.
Chicago
Shen, A., Hong, F., Liu, L., Lin, J., Wei, L., Cai, Q., Hong, Z., Peng, J."Pien Tze Huang inhibits the proliferation of human colon carcinoma cells by arresting G1/S cell cycle progression". Oncology Letters 4, no. 4 (2012): 767-770. https://doi.org/10.3892/ol.2012.811
Copy and paste a formatted citation
x
Spandidos Publications style
Shen A, Hong F, Liu L, Lin J, Wei L, Cai Q, Hong Z and Peng J: Pien Tze Huang inhibits the proliferation of human colon carcinoma cells by arresting G1/S cell cycle progression. Oncol Lett 4: 767-770, 2012.
APA
Shen, A., Hong, F., Liu, L., Lin, J., Wei, L., Cai, Q. ... Peng, J. (2012). Pien Tze Huang inhibits the proliferation of human colon carcinoma cells by arresting G1/S cell cycle progression. Oncology Letters, 4, 767-770. https://doi.org/10.3892/ol.2012.811
MLA
Shen, A., Hong, F., Liu, L., Lin, J., Wei, L., Cai, Q., Hong, Z., Peng, J."Pien Tze Huang inhibits the proliferation of human colon carcinoma cells by arresting G1/S cell cycle progression". Oncology Letters 4.4 (2012): 767-770.
Chicago
Shen, A., Hong, F., Liu, L., Lin, J., Wei, L., Cai, Q., Hong, Z., Peng, J."Pien Tze Huang inhibits the proliferation of human colon carcinoma cells by arresting G1/S cell cycle progression". Oncology Letters 4, no. 4 (2012): 767-770. https://doi.org/10.3892/ol.2012.811
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