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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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October 2012 Volume 4 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

The expression and clinical significance of PI3K, pAkt and VEGF in colon cancer

  • Authors:
    • Yinxu Zhang
    • Xiaomei Liu
    • Junhua Zhang
    • Leiyu Li
    • Chunying Liu

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Liaoning University of Traditional Chinese Medicine, Shenyang 110032, P.R. China, Department of Surgery, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121001, P.R. China
  • Pages: 763-766
    |
    Published online on: July 25, 2012
       https://doi.org/10.3892/ol.2012.822
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Abstract

Background PI3K/Akt signaling has been shown to be activated in a variety of cancers. However, the correlation between Akt activation and VEGF expression is unclear in colon cancer tissues. This study aimed to investigate the expression and predictive value of phosphorylated Akt (pAkt) and VEGF in colon cancer tissues. The expression of PI3K, pAkt and VEGF was detected by immunohistochemical staining in 60 samples of colon cancer tissues and their corresponding adjacent normal colon tissues. In addition, the correlations between the expression levels of the 3 proteins and the clinicopathological parameters of the colon cancer cases were analyzed. The positive rates of PI3K, pAkt and VEGF expression were 71.7% (43/60), 68.3% (41/60) and 61.7% (37/60) in colon cancer, respectively, which were significantly higher than in adjacent normal colon tissues (P<0.001). Correlation analyses showed that PI3K expression was not significantly associated with the gender or age of the patients, tumor size or differentiation (P>0.05), but was closely associated with serous coat infiltration and lymphatic metastasis of colon cancer (P<0.05). Neither pAkt nor VEGF expression were significantly associated with the gender or age of the patients, or tumor differentiation (P>0.05), but were closely associated with tumor size, serous coat infiltration and lymphatic metastasis of colon cancer (P<0.05). In addition, the expression levels of Pl3K and pAkt were positively correlated with that of VEGF in colon cancer tissues (P<0.05). Our data show a positive correlation between PI3K/Akt activation and VEGF expression in colon cancer tissues and indicate that pAkt is an independent prognostic marker for colon cancer patients.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Liu X, Zhang J, Li L and Liu C: The expression and clinical significance of PI3K, pAkt and VEGF in colon cancer. Oncol Lett 4: 763-766, 2012.
APA
Zhang, Y., Liu, X., Zhang, J., Li, L., & Liu, C. (2012). The expression and clinical significance of PI3K, pAkt and VEGF in colon cancer. Oncology Letters, 4, 763-766. https://doi.org/10.3892/ol.2012.822
MLA
Zhang, Y., Liu, X., Zhang, J., Li, L., Liu, C."The expression and clinical significance of PI3K, pAkt and VEGF in colon cancer". Oncology Letters 4.4 (2012): 763-766.
Chicago
Zhang, Y., Liu, X., Zhang, J., Li, L., Liu, C."The expression and clinical significance of PI3K, pAkt and VEGF in colon cancer". Oncology Letters 4, no. 4 (2012): 763-766. https://doi.org/10.3892/ol.2012.822
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Liu X, Zhang J, Li L and Liu C: The expression and clinical significance of PI3K, pAkt and VEGF in colon cancer. Oncol Lett 4: 763-766, 2012.
APA
Zhang, Y., Liu, X., Zhang, J., Li, L., & Liu, C. (2012). The expression and clinical significance of PI3K, pAkt and VEGF in colon cancer. Oncology Letters, 4, 763-766. https://doi.org/10.3892/ol.2012.822
MLA
Zhang, Y., Liu, X., Zhang, J., Li, L., Liu, C."The expression and clinical significance of PI3K, pAkt and VEGF in colon cancer". Oncology Letters 4.4 (2012): 763-766.
Chicago
Zhang, Y., Liu, X., Zhang, J., Li, L., Liu, C."The expression and clinical significance of PI3K, pAkt and VEGF in colon cancer". Oncology Letters 4, no. 4 (2012): 763-766. https://doi.org/10.3892/ol.2012.822
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