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Article

Neoadjuvant chemoradiotherapy followed by surgery in locally advanced squamous cell carcinoma of the vulva

  • Authors:
    • A. Gaudineau
    • D. Weitbruch
    • P. Quetin
    • S. Heymann
    • T. Petit
    • P. Volkmar
    • F. Bodin
    • M. Velten
    • J.F. Rodier
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Regional Paul Strauss Cancer Centre, 67065 Strasbourg, France, Department of Radiotherapy, Regional Paul Strauss Cancer Centre, 67065 Strasbourg, France, Department of Medical Oncology, Regional Paul Strauss Cancer Centre, 67065 Strasbourg, France, Department of Biostatistics, Regional Paul Strauss Cancer Centre, 67065 Strasbourg, France
  • Pages: 719-722
    |
    Published online on: July 27, 2012
       https://doi.org/10.3892/ol.2012.831
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Abstract

Alternative therapies have been sought to alleviate mutilation and morbidity associated with surgery for vulvar neoplasms. Our prime objective was to assess tumor absence in pathological vulvar and nodal specimens following neoadjuvant chemoradiotherapy in locally advanced vulvar neoplasms. Data were retrospectively collected from January 2001 to May 2009 from 22 patients treated with neoadjuvant therapy for locally advanced squamous cell carcinoma of the vulva. Neoadjuvant treatment consisted of inguino‑pelvic radiotherapy (50 Gy) in association with chemotherapy when possible. Surgery occurred at intervals of between 5 to 8 weeks. The median age of patients at diagnosis was 74.1 years. All patients were primarily treated with radiotherapy and 15 received a concomitant chemotherapy. Additionally, all patients underwent radical vulvectomy and bilateral inguino‑femoral lymphadenectomy. Tumor absence in the vulvar and nodal pathological specimens was achieved for 6 (27%) patients, while absence in the vulvar pathological specimens was only achieved for 10 (45.4%) patients. Postoperative follow‑up revealed breakdown of groin wounds, vulvar wounds and chronic lymphedema in 3 (14.3%), 7 (31.8%) and 14 cases (63.6%), respectively. Within a median follow‑up time of 2.3 years [interquartile range (IQR), 0.6‑4.6], 12 (54.6%) patients experienced complete remission and 6 cases succumbed to metastatic evolution within a median of 2.2 years (IQR, 0.6-4.6), with 1 case also experiencing perineal recurrence. Median survival time, estimated using the Kaplan-Meier method, was 5.1 years (IQR, 1.0‑6.8). We suggest that neoadjuvant chemoradiotherapy may represent a reliable and promising strategy in locally advanced squamous cell carcinoma of the vulva.
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Copy and paste a formatted citation
Spandidos Publications style
Gaudineau A, Weitbruch D, Quetin P, Heymann S, Petit T, Volkmar P, Bodin F, Velten M and Rodier J: Neoadjuvant chemoradiotherapy followed by surgery in locally advanced squamous cell carcinoma of the vulva. Oncol Lett 4: 719-722, 2012.
APA
Gaudineau, A., Weitbruch, D., Quetin, P., Heymann, S., Petit, T., Volkmar, P. ... Rodier, J. (2012). Neoadjuvant chemoradiotherapy followed by surgery in locally advanced squamous cell carcinoma of the vulva. Oncology Letters, 4, 719-722. https://doi.org/10.3892/ol.2012.831
MLA
Gaudineau, A., Weitbruch, D., Quetin, P., Heymann, S., Petit, T., Volkmar, P., Bodin, F., Velten, M., Rodier, J."Neoadjuvant chemoradiotherapy followed by surgery in locally advanced squamous cell carcinoma of the vulva". Oncology Letters 4.4 (2012): 719-722.
Chicago
Gaudineau, A., Weitbruch, D., Quetin, P., Heymann, S., Petit, T., Volkmar, P., Bodin, F., Velten, M., Rodier, J."Neoadjuvant chemoradiotherapy followed by surgery in locally advanced squamous cell carcinoma of the vulva". Oncology Letters 4, no. 4 (2012): 719-722. https://doi.org/10.3892/ol.2012.831
Copy and paste a formatted citation
x
Spandidos Publications style
Gaudineau A, Weitbruch D, Quetin P, Heymann S, Petit T, Volkmar P, Bodin F, Velten M and Rodier J: Neoadjuvant chemoradiotherapy followed by surgery in locally advanced squamous cell carcinoma of the vulva. Oncol Lett 4: 719-722, 2012.
APA
Gaudineau, A., Weitbruch, D., Quetin, P., Heymann, S., Petit, T., Volkmar, P. ... Rodier, J. (2012). Neoadjuvant chemoradiotherapy followed by surgery in locally advanced squamous cell carcinoma of the vulva. Oncology Letters, 4, 719-722. https://doi.org/10.3892/ol.2012.831
MLA
Gaudineau, A., Weitbruch, D., Quetin, P., Heymann, S., Petit, T., Volkmar, P., Bodin, F., Velten, M., Rodier, J."Neoadjuvant chemoradiotherapy followed by surgery in locally advanced squamous cell carcinoma of the vulva". Oncology Letters 4.4 (2012): 719-722.
Chicago
Gaudineau, A., Weitbruch, D., Quetin, P., Heymann, S., Petit, T., Volkmar, P., Bodin, F., Velten, M., Rodier, J."Neoadjuvant chemoradiotherapy followed by surgery in locally advanced squamous cell carcinoma of the vulva". Oncology Letters 4, no. 4 (2012): 719-722. https://doi.org/10.3892/ol.2012.831
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