Small duodenal gastrointestinal stromal tumor presenting with acute bleeding misdiagnosed as hemobilia: Two case reports

Introduction

Gastrointestinal stromal tumors (GISTs) are the most common type of mesenchymal tumor of the gastrointestinal tract (1). The majority of GISTs test positive for mutations in the v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT) gene. This leads to the expression of CD34 or the protein marker CD117, which is also known as the mast/stem cell growth factor receptor (SCFR) and c-Kit (2). Approximately 60, 30 and 1–2% of GIST cases occur in the stomach, small intestine and the colon or rectum, respectively. GISTs of the esophagus are rare (3).

The most common presentation of GIST is bleeding of the upper gastrointestinal tract, which may be either acute or chronic, and results in anemia (4). Complete surgical resection remains the best treatment option. Unlike carcinomas, GIST does not widely infiltrate at the microscopic level and rarely metastasizes to the lymph nodes; therefore, local excision may be appropriate when technically feasible.

GISTs of the duodenum occur in less than 4% of all cases and frequently involve the descending portion (5). As the GIST grows, the central portion becomes necrotic and forms a deeply penetrating ulcer, which may result in hematemesis. Under the gastroscope, the tumor may appear similar to a papilla; therefore, it is difficult to distinguish between a patient with hemobilia and a patient with a small duodenal GIST. In the present study, we report 2 cases of small duodenal GIST (less than 2 cm in size), which at first were misdiagnosed as hemobilia. The study was approved by the ethics committee of the Second Affiliated Hospital of Dalian Medical University. Patient consent was obtained both from the patient and the patient’s families.

Case report

Patient 1

A 66-year-old male was admitted to The Second Affiliated Hospital of Dalian Medical University (Dalian, China) with syncope. The patient presented with heartburn and melena for 17 days. There was no associated fever, dyspeptic symptoms or localized abdominal pain and the hemoglobin level upon admission was 29 g/l. Due to the patient’s poor condition, a blood transfusion and a high ligation of the great saphenous vein were conducted.

Emergent upper gastrointestinal endoscopy revealed bleeding from a duodenal papilla (Fig. 1), which was diagnosed as hemobilia; however, further angiography did not support this result. Although the blood transfusion level was increased to 12,000 ml, the hemoglobin level remained at 41 g/l (reference range, 120–160 g/l). There was no time to conduct other accessory examinations. To save the patient’s life, an exploratory laparotomy was conducted. During the surgery, numerous blood clots were identified in the second part of the duodenum, and no bleeding was identified in the duodenal papilla. A submucosal tumor (<2 cm) with signs of ulceration and oozing at the upper end was revealed on the descending section of the duodenum (Fig. 2A and B). The tumor was <2 cm in diameter, and 1 cm from the papilla. Peritoneal dissemination and liver metastasis were not observed.

Figure 1 Patient 1. Upper gastrointestinal endoscopic examination revealed an ulcer, heavily accompanied by blood clots, which appeared to be a duodenal papilla.

Figure 2 Patient 1. (A) The descending section of the duodenum was incised and an oozing submucosal tumor (<2 cm) was identified. (B) The tumor measured 1.8 cm at its greatest dimension and formed a deep ulcer.

On the basis of these observations, and since the patient was elderly and weakening, a wedge resection was conducted. The histopathological examination of the resected lesion revealed a GIST. The patient did not undergo chemotherapy following surgery and, to date, has been free from recurrence.

Patient 2

A 71-year-old female with no previous medical history presented with a 2-month history of melena. The patient felt nauseated, suddenly vomited ∼50 ml of blood and was immediately taken to a local hospital.

An upper gastrointestinal endoscopy resulted in a diagnosis of hemobilia. The patient was then transferred to The Second Affiliated Hospital of Dalian Medical University for further treatment. From our previous experience with patient 1, we understood that endoscopic diagnosis comprises certain limitations. Therefore, the patient underwent barium swallow and a contrast-enhanced computed tomography (CT) scan, which revealed a high-density area in the descending duodenum (Fig. 3A and B).

Figure 3 Patient 2. (A) Tumor located in the descending duodenum with typical strengthening CT appearance (arrow, duodenal GIST). (B) Gastrointestinal imaging identifed a circular notch convex to the intestine on the descending duodenum. A and B both indicate the presence of a tumor on the descending duodenum. CT, computed tomography.

An endoscopy was then conducted by an experienced practitioner, who identified a tumor <2 cm in diameter following sufficient washing of the bleeding site. The tumor revealed an area of necrosis and ulceration, which had a similar appearance to a duodenal papilla (Fig. 4). We temporarily controlled the bleeding by sclerotherapy, then a wedge resection was conducted to permanently terminate the bleeding. During the procedure, we identified that the tumor was notably small and located ∼1 cm from the papilla. Peritoneal dissemination and liver metastasis were not observed.

Figure 4 Patient 2. Endoscopic examination revealed a tumor which necrotized in the center and formed a duodenal papilla-like ulcer.

Gross examination revealed a 1.5x2.0-cm submucosal tumor covered with blood and containing a central ulceration (Fig. 5). Upon histopathological examination, the resected lesion was identified as a GIST. The patient did not undergo chemotherapy following surgery, and to date, has been free from recurrence.

Figure 5 Patient 2. The tumor measured 2.0 cm at its greatest dimension, with a deep ulceration and necrotic center.

Discussion

GIST is the most common type of mesenchymal tumor, which appears to originate from the gastrointestinal wall, mesentery, omentum or retroperitoneum. GISTs usually occur on the stomach or small bowel, and only 1–4% are located in the duodenum. Depending on their size, location and the presence of mucosal ulceration, GISTs most often present with gastrointestinal bleeding, abdominal pain and obstructive jaundice (6).

The most typical feature of a duodenal GIST is the formation of a deep ulceration in the mucosa or an intramural mass with a centrally ulcerated umbilication (7). Therefore, bleeding is the most common symptom at presentation. Bleeding may cause acute abdominal pain and severe anemia, which may require emergency surgery. In the presented cases, the most common symptom was anemia, and in previous studies, anemia and gastrointestinal bleeding were observed in 48% of cases with ulcerated lesions (8).

The gross ulceration of a GIST in the duodenum facilitates the detection of the tumor under endoscopic examination; however, a small duodenal tumor (less than 2 cm in size) is easily confused with a duodenal papilla. In the presented cases, the endoscopic diagnosis for both patients was hemobilia. In hemobilia, acute upper gastrointestinal bleeding is one of the most common life-threatening conditions; therefore, the sooner the cause of bleeding is identified, the sooner the patients are out of danger. For this reason, a complete examination should be conducted during upper gastrointestinal bleeding to prevent misdiagnosis.

To date, there are no recognized specific radiological examinations for duodenal GIST diagnosis; however, a gastroscopy may be a useful procedure. Under the endoscope, it is possible to observe the hemorrhagic area, arrest the bleeding and conduct a biopsy. More attention should be paid to the bleeding from the descending part of the duodenum. When there is deep ulceration of the tumor, the endoscopic appearance may be confused with hemobilia by an insufficiently observant gastroscopy operator, particularly when the tumor diameter is less than 2 cm and markedly accompanied with blood clots. The barium swallow examination may be complementary to gastroscopy in the differential diagnosis of hemobilia and tumor bleeding.

Contrast-enhanced CT is the standard preoperative imaging technique. It usually exposes a mass originating from the digestive tract wall and reveals the tumor size and presence of secondary localizations (e.g., hepatic metastases). In patient 2, the barium swallow examination demonstrated a filling defect, indicating the presence of a mass causing a mucosal irregularity. A contrast-enhanced CT scan revealed a high density lesion in the descending part of the duodenum. Utilizing the barium swallow examination and contrast-enhanced CT scan may help prevent a misdiagnosis of hemobilia. Thus, a gastroscopy, contrast-enhanced CT scan and barium swallow examination are recommended to increase the preoperative diagnostic rate for small duodenal GISTs.

In conclusion, the two duodenal GIST (less than 2 cm in size) cases presented were initially misdiagnosed as hemobilia. To the best of our knowledge, this is the first published acknowledgment that such a misdiagnosis may be likely. To avoid misdiagnosis, a gastroscopy, contrast-enhanced CT scan and barium swallow examination should be routinely conducted.

Acknowledgements

This study was supported by grants from the Chinese National Natural Science Foundation Projects (30870550) and the Chinese State Key Program in Basic Research (2012CB822103).

References