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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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May 2013 Volume 5 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Case Report

Gefitinib in combination with prednisolone to avoid interstitial lung disease during non-small cell lung cancer treatment: A case report

  • Authors:
    • Xinying Xue
    • Qingliang Xue
    • Yuxia Liu
    • Lei Pan
    • Kaifei Wang
    • Lina Zhang
    • Na Wang
    • Bing Yang
    • Jianxin Wang
  • View Affiliations / Copyright

    Affiliations: Cadres Respiratory Diseases Department of Beijing Shijitan Hospital, Beijing 100038, P.R. China, Department of Respiratory Diseases of Chinese PLA General Hospital, Beijing 100853, P.R. China, Research Department of Chinese Academy of Medical Sciences, Beijing 100864, P.R. China
  • Pages: 1599-1600
    |
    Published online on: February 27, 2013
       https://doi.org/10.3892/ol.2013.1212
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Abstract

Gefitinib-induced interstitial lung disease (ILD) is a rare but lethal drug adverse event, which usually leads to the withdrawal of gefitinib and causes complications with anticancer treatment. In this study, gefitinib administration combined with prednisolone in a female with stage IIIb non‑small cell lung cancer (NSCLC) produced a good outcome without inducing ILD. The results suggested that combined administration of gefitinib with glucocorticoids may be an efficient method to treat NSCLC while avoiding complications with ILD.
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1 

Toffoli G, De Mattia E, Cecchin E, Biason P, Masier S and Corona G: Pharmacology of epidermal growth factor inhibitors. Int J Biol Markers. 22(1 Suppl 4): S24–S39. 2007.PubMed/NCBI

2 

Cappuzzo F, Hirsch FR, Rossi E, Bartolini S, Ceresoli GL, Bemis L, Haney J, Witta S, Danenberg K, Domenichini I, Ludovini V, et al: Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non small-cell lung cancer. J Natl Cancer Inst. 97:643–655. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Ieki R, Saitoh E and Shibuya M: Acute lung injury as a possible adverse drug reaction related to gefitinib. Eur Respir J. 22:179–181. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Inoue A, Saijo Y, Maemondo M, Gomi K, Tokue Y, Kimura Y, Ebina M, Kikuchi T, Moriya T and Nukiwa T: Severe acute interstitial pneumonia and gefitinib. Lancet. 361:137–139. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Cohen MH, Williams GA, Sridhara R, Chen G and Pazdur R: FDA drug approval summary: gefitinib (ZD1839) (Iressa) tablets. Oncologist. 8:303–306. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Kudoh S, Kato H, Nishiwaki Y, Fukuoka M, Nakata K, Ichinose Y, Tsuboi M, Yokota S, Nakagawa K, Suga M, et al; Japan Thoracic Radiology Group. Interstitial lung disease in Japanese patients with lung cancer: a cohort and nested case-control study. Am J Respir Crit Care Med. 177:1348–1357. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Gupta A and Raina V: Geftinib. J Cancer Res Ther. 6:249–254. 2010. View Article : Google Scholar

8 

Suzuki M, Asahina H, Konishi J, Yamazaki K and Nishimura M: Recurrent gefitinib-induced interstitial lung disease. Intern Med. 47:533–536. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Gemma A: Drug-induced interstitial lung diseases associated with molecular-targeted anticancer agents. J Nippon Med Sch. 76:4–8. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xue X, Xue Q, Liu Y, Pan L, Wang K, Zhang L, Wang N, Yang B and Wang J: Gefitinib in combination with prednisolone to avoid interstitial lung disease during non-small cell lung cancer treatment: A case report. Oncol Lett 5: 1599-1600, 2013.
APA
Xue, X., Xue, Q., Liu, Y., Pan, L., Wang, K., Zhang, L. ... Wang, J. (2013). Gefitinib in combination with prednisolone to avoid interstitial lung disease during non-small cell lung cancer treatment: A case report. Oncology Letters, 5, 1599-1600. https://doi.org/10.3892/ol.2013.1212
MLA
Xue, X., Xue, Q., Liu, Y., Pan, L., Wang, K., Zhang, L., Wang, N., Yang, B., Wang, J."Gefitinib in combination with prednisolone to avoid interstitial lung disease during non-small cell lung cancer treatment: A case report". Oncology Letters 5.5 (2013): 1599-1600.
Chicago
Xue, X., Xue, Q., Liu, Y., Pan, L., Wang, K., Zhang, L., Wang, N., Yang, B., Wang, J."Gefitinib in combination with prednisolone to avoid interstitial lung disease during non-small cell lung cancer treatment: A case report". Oncology Letters 5, no. 5 (2013): 1599-1600. https://doi.org/10.3892/ol.2013.1212
Copy and paste a formatted citation
x
Spandidos Publications style
Xue X, Xue Q, Liu Y, Pan L, Wang K, Zhang L, Wang N, Yang B and Wang J: Gefitinib in combination with prednisolone to avoid interstitial lung disease during non-small cell lung cancer treatment: A case report. Oncol Lett 5: 1599-1600, 2013.
APA
Xue, X., Xue, Q., Liu, Y., Pan, L., Wang, K., Zhang, L. ... Wang, J. (2013). Gefitinib in combination with prednisolone to avoid interstitial lung disease during non-small cell lung cancer treatment: A case report. Oncology Letters, 5, 1599-1600. https://doi.org/10.3892/ol.2013.1212
MLA
Xue, X., Xue, Q., Liu, Y., Pan, L., Wang, K., Zhang, L., Wang, N., Yang, B., Wang, J."Gefitinib in combination with prednisolone to avoid interstitial lung disease during non-small cell lung cancer treatment: A case report". Oncology Letters 5.5 (2013): 1599-1600.
Chicago
Xue, X., Xue, Q., Liu, Y., Pan, L., Wang, K., Zhang, L., Wang, N., Yang, B., Wang, J."Gefitinib in combination with prednisolone to avoid interstitial lung disease during non-small cell lung cancer treatment: A case report". Oncology Letters 5, no. 5 (2013): 1599-1600. https://doi.org/10.3892/ol.2013.1212
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