Association of vitamin D receptor gene polymorphisms with pancreatic cancer: A pilot study in a North China Population

  • Authors:
    • Lei Li
    • Bo Wu
    • Libo Yang
    • Guancheng Yin
    • Wei Wei
    • Shujing Sui
    • Jiyong Liu
  • View Affiliations

  • Published online on: February 28, 2013     https://doi.org/10.3892/ol.2013.1215
  • Pages: 1731-1735
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Abstract

Polymorphisms of the vitamin D receptor (VDR) gene may be a risk factor for pancreatic cancer (PC). We investigated the association of two single-nucleotide polymorphisms (SNPs) of the VDR gene with PC in age- and gender-matched patients and controls. PC (n=91) and healthy control (n=80) samples were genotyped for the FokI (rs2228570) and BsmI (rs1544410) polymorphisms using the PCR and restriction fragment length polymorphism (PCR-RFLP) method. Chi-square analysis was used to test for the overall association of VDR genotype with disease. There was a significant difference in the frequency of genotype FF between the PC patients and controls (Ptrend=0.009); however, the difference in frequency of genotype BB between the two groups was not significant (Ptrend=0.082). The difference between FF and Ff/ff frequency was significant (P=0.002). The two high-risk genotypes were ffbb and Ffbb, with an 11.66- and 6.42-fold increased risk of PC, respectively. VDR gene polymorphisms were important for the development of PC in this study population; however, further exploration of these findings and their implications are required.
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May 2013
Volume 5 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li L, Wu B, Yang L, Yin G, Wei W, Sui S and Liu J: Association of vitamin D receptor gene polymorphisms with pancreatic cancer: A pilot study in a North China Population. Oncol Lett 5: 1731-1735, 2013
APA
Li, L., Wu, B., Yang, L., Yin, G., Wei, W., Sui, S., & Liu, J. (2013). Association of vitamin D receptor gene polymorphisms with pancreatic cancer: A pilot study in a North China Population. Oncology Letters, 5, 1731-1735. https://doi.org/10.3892/ol.2013.1215
MLA
Li, L., Wu, B., Yang, L., Yin, G., Wei, W., Sui, S., Liu, J."Association of vitamin D receptor gene polymorphisms with pancreatic cancer: A pilot study in a North China Population". Oncology Letters 5.5 (2013): 1731-1735.
Chicago
Li, L., Wu, B., Yang, L., Yin, G., Wei, W., Sui, S., Liu, J."Association of vitamin D receptor gene polymorphisms with pancreatic cancer: A pilot study in a North China Population". Oncology Letters 5, no. 5 (2013): 1731-1735. https://doi.org/10.3892/ol.2013.1215