Malignant lymphoma of mucosa‑associated lymphoid tissue involving the renal pelvis and the entire ureter: A case report

Otsuki,Hideo; Ito,Keiichi; Sato,Ken; Kosaka,Takeo; Shimazaki,Hideyuki; Kaji,Tatsumi; Asano,Tomohiko

doi:10.3892/ol.2013.1221

May 2013 Volume 5 Issue 5

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May 2013 Volume 5 Issue 5

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Case Report

Malignant lymphoma of mucosa‑associated lymphoid tissue involving the renal pelvis and the entire ureter: A case report

Authors:
- Hideo Otsuki
- Keiichi Ito
- Ken Sato
- Takeo Kosaka
- Hideyuki Shimazaki
- Tatsumi Kaji
- Tomohiko Asano
View Affiliations / Copyright

Affiliations: Department of Urology, National Defense Medical College, Tokorozawa, Saitama 359‑8513, Japan, Department of Hematology, National Defense Medical College, Tokorozawa, Saitama 359‑8513, Japan, Department of Basic Pathology, National Defense Medical College, Tokorozawa, Saitama 359‑8513, Japan, Department of Radiology, National Defense Medical College, Tokorozawa, Saitama 359‑8513, Japan
Pages: 1625-1628
|
Published online on: March 1, 2013

https://doi.org/10.3892/ol.2013.1221
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Abstract

Mucosa‑associated lymphoid tissue (MALT) lymphoma occurs in various sites, but rarely in the urinary tract. Imaging studies of a 69‑year‑old male revealed a left hydronephrosis and diffuse thickening of the renal pelvic and upper ureteral wall. Retrograde pyelography revealed a narrowing in this region, and brush cytology specimens contained atypical cells. As the lesion was considered to be malignant, surgical excision was performed. Histological analysis revealed an intense lymphoid infiltrate mainly consisting of B cells. The immunohistochemistry results demonstrated that the lesion was positive for CD20 and CD79a and negative for CD5 and cyclin D1. These findings led to a diagnosis of MALT lymphoma. Pathological exploration disclosed a focally dense invasion of lymphoma cells into not only the renal pelvis, but the whole ureteral wall and surrounding tissue; therefore, the patient underwent eight courses of rituximab treatment. Diffuse invasion of lymphoma cells into the whole ureter was rarely observed. Since the surgery, the patient has survived for 78 months without evidence of a recurrence of lymphoma.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Malignant lymphoma of mucosa‑associated lymphoid tissue involving the renal pelvis and the entire ureter: A case report

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