Serum levels of vascular endothelial growth factor are increased and correlate with malnutrition, immunosuppression involving MDSCs and systemic inflammation in patients with cancer of the digestive system

Nakamura,Izumi; Shibata,Masahiko; Gonda,Kenji; Yazawa,Takashi; Shimura,Tatsuo; Anazawa,Takayuki; Suzuki,Satoshi; Sakurai,Kenichi; Koyama,Yoshihisa; Ohto,Hitoshi; Tomita,Ryouichi; Gotoh,Mitsukazu; Takenoshita,Seiichi

doi:10.3892/ol.2013.1231

May 2013 Volume 5 Issue 5

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May 2013 Volume 5 Issue 5

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Article

Serum levels of vascular endothelial growth factor are increased and correlate with malnutrition, immunosuppression involving MDSCs and systemic inflammation in patients with cancer of the digestive system

Authors:
- Izumi Nakamura
- Masahiko Shibata
- Kenji Gonda
- Takashi Yazawa
- Tatsuo Shimura
- Takayuki Anazawa
- Satoshi Suzuki
- Kenichi Sakurai
- Yoshihisa Koyama
- Hitoshi Ohto
- Ryouichi Tomita
- Mitsukazu Gotoh
- Seiichi Takenoshita
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Affiliations: Department of Organ Regulatory Surgery, Fukushima Medical University, Fukushima 960‑1295, Japan, Department of Tumor and Host Bioscience, Fukushima Medical University, Fukushima 960‑1295, Japan, Department of Regenerative Surgery, Fukushima Medical University, Fukushima 960‑1295, Japan, Department of Surgery, Nihon University School of Medicine, Itabashi, Tokyo 173‑8610, Japan, Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University, Fukushima 960‑1295, Japan, Department of Surgery, Nippon Dental University, Chiyoda, Tokyo 102‑8158, Japan
Pages: 1682-1686
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Published online on: March 6, 2013

https://doi.org/10.3892/ol.2013.1231
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Abstract

Vascular endothelial growth factor (VEGF) reportedly has an important role in the progression of malignant neoplasms and has been reported to induce myeloid‑derived suppressor cells (MDSCs) that appear in cancer and inflammation. In the present study, serum concentrations of VEGF were measured in patients with digestive system cancer and the correlations with nutritional damage, immune suppression and systemic inflammation were analyzed. A significant increase in VEGF serum levels was observed in patients with esophageal, gastric and colorectal cancers compared with healthy volunteers. Levels of VEGF were inversely correlated with the serum concentrations of albumin, prealbumin and retinol‑binding protein. The serum concentrations of VEGF were inversely correlated with the production of interleukin (IL)‑12 and correlated with MDSC counts. VEGF levels were also correlated with neutrophil and neutrophil/lymphocyte counts and inversely correlated with lymphocyte count. Serum VEGF levels were divided at a cutoff of 500 pg/ml, with levels of prealbumin and retinol‑binding protein significantly decreased in patients with higher VEGF levels. The stimulation index and IL‑12 production were significantly decreased in the group with higher VEGF levels and MDSC counts tended to be higher in this group. These results demonstrated that increased production of VEGF was correlated with systemic inflammation, nutritional impairment and the inhibition of cell‑mediated immunity involving MDSCs.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Serum levels of vascular endothelial growth factor are increased and correlate with malnutrition, immunosuppression involving MDSCs and systemic inflammation in patients with cancer of the digestive system

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