Isolated metastases of hepatocellular carcinoma in the right atrium: Case report and review of the literature

  • Authors:
    • Manri Kawakami
    • Masahiko Koda
    • Mari Mandai
    • Keiko Hosho
    • Yoshikazu Murawaki
    • Wakako Oda
    • Kazuhiko Hayashi
  • View Affiliations

  • Published online on: March 8, 2013     https://doi.org/10.3892/ol.2013.1240
  • Pages: 1505-1508
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Abstract

The aim of this study was to clarify the clinical features of patients with isolated HCC metastases to the heart. A 66‑year‑old female hospitalized with a hepatocellular carcinoma (HCC) ranging from the right to the left lobe and with a tumor thrombus in the main portal vein, was treated with intraarterial cisplatin, 5‑fluouracil, adriamycin and mitomycin. Computed tomography (CT) one month later revealed that the HCC had progressed with multiple lung metastases and moderate ascites. The patient had no symptoms. Magnetic resonance imaging (MRI) and echocardiography revealed a round, movable tumor with a diameter of 2 cm in the right atrium (RA). The patient succumbed to HCC five months later. An autopsy revealed HCC with portal tumor thrombi and metastases to the lungs, inferior vena cava (IVC) and RA. The metastases in the RA and IVC were not continous with the intrahepatic tumor and were histologically attached to the endocardium and endothelium, respectively. An isolated metastasis of a HCC of the RA and IVC is extremely rare. In conclusion, although the majority of isolated metastases of HCC to the heart were diagnosed by echocardiography and were treated with mainly surgery, they had poor prognosis. The echocardiography should be performed for patients with advanced HCC. A novel treatment including molecular targeted drugs is required.
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May 2013
Volume 5 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Kawakami M, Koda M, Mandai M, Hosho K, Murawaki Y, Oda W and Hayashi K: Isolated metastases of hepatocellular carcinoma in the right atrium: Case report and review of the literature. Oncol Lett 5: 1505-1508, 2013
APA
Kawakami, M., Koda, M., Mandai, M., Hosho, K., Murawaki, Y., Oda, W., & Hayashi, K. (2013). Isolated metastases of hepatocellular carcinoma in the right atrium: Case report and review of the literature. Oncology Letters, 5, 1505-1508. https://doi.org/10.3892/ol.2013.1240
MLA
Kawakami, M., Koda, M., Mandai, M., Hosho, K., Murawaki, Y., Oda, W., Hayashi, K."Isolated metastases of hepatocellular carcinoma in the right atrium: Case report and review of the literature". Oncology Letters 5.5 (2013): 1505-1508.
Chicago
Kawakami, M., Koda, M., Mandai, M., Hosho, K., Murawaki, Y., Oda, W., Hayashi, K."Isolated metastases of hepatocellular carcinoma in the right atrium: Case report and review of the literature". Oncology Letters 5, no. 5 (2013): 1505-1508. https://doi.org/10.3892/ol.2013.1240