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May 2013 Volume 5 Issue 5

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Case Report

Autologous immune enhancement therapy: A case report of a stage IV colonic cancer

  • Authors:
    • Baskar Subramani
    • Kananathan Ratnavelu
    • Chithra Ramanathan Pullai
    • Kohila Krishnan
    • Sheela Devi Sugadan
    • Xuewen Deng
    • Terunuma Hiroshi
  • View Affiliations / Copyright

    Affiliations: Nichi-Asia Life Sciences Sdn. Bhd., Petaling Jaya 47810, Malaysia, Nilai Cancer Institute (NCI) Hospital, Nilai 71800, Malaysia, Biotherapy Institute of Japan, Tokyo 135-0051, Japan
  • Pages: 1611-1614
    |
    Published online on: March 12, 2013
       https://doi.org/10.3892/ol.2013.1246
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Abstract

Current modalities of cancer treatment, including surgery, chemotherapy and radiotherapy, show marginal therapeutic responses in cancer patients. In adoptive immunotherapy, interleukin-2 (IL-2) activated immune cells demonstrated notable results in patients with advanced malignant disease. The present study reports the efficacy and safety of repetitive infusions of autologous immune enhancement therapy (AIET) in a stage IV colonic cancer patient who had already received first-line chemotherapeutic drugs. Peripheral blood was aspirated from the patient. Specifically, natural killer (NK) cells and T-lymphocytes were isolated from the peripheral blood mononuclear cells (PBMCs). These cells were activated and expanded ex vivo for 14 days and were transfused intravenously to the patient. After six infusions of AIET, the carcinoembryonic antigen (CEA) level was decreased from 901 to 437 U/ml, regression of lesions was noted and there were no adverse reactions during the course of this therapy. Thus, AIET may be a promising anticancer approach to eradicate tumor cells with other conventional therapies.
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Copy and paste a formatted citation
Spandidos Publications style
Subramani B, Ratnavelu K, Pullai CR, Krishnan K, Sugadan SD, Deng X and Hiroshi T: Autologous immune enhancement therapy: A case report of a stage IV colonic cancer. Oncol Lett 5: 1611-1614, 2013.
APA
Subramani, B., Ratnavelu, K., Pullai, C.R., Krishnan, K., Sugadan, S.D., Deng, X., & Hiroshi, T. (2013). Autologous immune enhancement therapy: A case report of a stage IV colonic cancer. Oncology Letters, 5, 1611-1614. https://doi.org/10.3892/ol.2013.1246
MLA
Subramani, B., Ratnavelu, K., Pullai, C. R., Krishnan, K., Sugadan, S. D., Deng, X., Hiroshi, T."Autologous immune enhancement therapy: A case report of a stage IV colonic cancer". Oncology Letters 5.5 (2013): 1611-1614.
Chicago
Subramani, B., Ratnavelu, K., Pullai, C. R., Krishnan, K., Sugadan, S. D., Deng, X., Hiroshi, T."Autologous immune enhancement therapy: A case report of a stage IV colonic cancer". Oncology Letters 5, no. 5 (2013): 1611-1614. https://doi.org/10.3892/ol.2013.1246
Copy and paste a formatted citation
x
Spandidos Publications style
Subramani B, Ratnavelu K, Pullai CR, Krishnan K, Sugadan SD, Deng X and Hiroshi T: Autologous immune enhancement therapy: A case report of a stage IV colonic cancer. Oncol Lett 5: 1611-1614, 2013.
APA
Subramani, B., Ratnavelu, K., Pullai, C.R., Krishnan, K., Sugadan, S.D., Deng, X., & Hiroshi, T. (2013). Autologous immune enhancement therapy: A case report of a stage IV colonic cancer. Oncology Letters, 5, 1611-1614. https://doi.org/10.3892/ol.2013.1246
MLA
Subramani, B., Ratnavelu, K., Pullai, C. R., Krishnan, K., Sugadan, S. D., Deng, X., Hiroshi, T."Autologous immune enhancement therapy: A case report of a stage IV colonic cancer". Oncology Letters 5.5 (2013): 1611-1614.
Chicago
Subramani, B., Ratnavelu, K., Pullai, C. R., Krishnan, K., Sugadan, S. D., Deng, X., Hiroshi, T."Autologous immune enhancement therapy: A case report of a stage IV colonic cancer". Oncology Letters 5, no. 5 (2013): 1611-1614. https://doi.org/10.3892/ol.2013.1246
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