Differential expression of miRNAs in esophageal cancer tissue

Liu,Shang-Guo; Qin,Xiu-Guang; Zhao,Bao-Sheng; Qi,Bo; Yao,Wen‑Jian; Wang,Tian-Yun; Li,Han-Chen; Wu,Xiang-Nan

doi:10.3892/ol.2013.1251

May 2013 Volume 5 Issue 5

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May 2013 Volume 5 Issue 5

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Article

Differential expression of miRNAs in esophageal cancer tissue

Authors:
- Shang-Guo Liu
- Xiu-Guang Qin
- Bao-Sheng Zhao
- Bo Qi
- Wen‑Jian Yao
- Tian-Yun Wang
- Han-Chen Li
- Xiang-Nan Wu
View Affiliations / Copyright

Affiliations: Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, P.R. China, Department of Biochemistry and Molecular Biology, Xinxiang Medical University, Henan, Xinxiang 453003, P.R. China
Pages: 1639-1642
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Published online on: March 12, 2013

https://doi.org/10.3892/ol.2013.1251
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Abstract

The aim of this study was to explore the association of specific microRNAs (miRNAs) with the development of esophageal cancer (EC) and to identify new molecular markers for EC by analyzing the expression profiles of miRNAs in EC tissues. The expression profiles of miRNAs in paired EC and paracancerous normal tissues were detected and bioinformatically analyzed using miRNA assays. The outcomes were validated using real-time polymerase chain reaction. The miRNA assays revealed a total of 60 differentially expressed miRNAs in the EC tissues compared with those in the paracancerous normal tissues. Among them, 51 had doubled or more than doubled their expression levels and 9 had halved their expression levels. The most markedly upregulated miRNAs were hsa-miR-15a, hsa-miR-28-3p, hsa-miR-31, hsa-miR-99b, hsa-miR-101, hsa-miR-130a, hsa-miR-143, hsa-miR-196b, hsa-miR-200a, hsa-miR-210, hsa-miR-452 and hsa-miR-27a, whereas the most markedly downregulated miRNAs included hsa-miR-30b, hsa-miR-223, hsa-miR-454, hsa-miR-486, hsa-miR-574-3p and hsa-miR-126. Specific miRNA expression profiles exist in EC tissues and may serve as novel EC molecular markers.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Differential expression of miRNAs in esophageal cancer tissue

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Abstract

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