Pericardial synovial sarcoma in a dyspnoeic female with tuberculous pericarditis: A case report
- Authors:
- Xia Wu
- Ran Chen
- Bowen Zhao
View Affiliations
Affiliations: Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University College of Medicine and Sir Run Run Shaw Institute of Clinical Medicine, Hangzhou, Zhejiang 310016, P.R. China, Department of Diagnostic Ultrasound and Echocardiography, Sir Run Run Shaw Hospital, Zhejiang University College of Medicine and Sir Run Run Shaw Institute of Clinical Medicine, Hangzhou, Zhejiang 310016, P.R. China
- Published online on: April 2, 2013 https://doi.org/10.3892/ol.2013.1279
-
Pages:
1973-1975
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Abstract
Synovial sarcomas of the pericardium are extremely rare and associated with poor survival rate. The current case report describes a 45‑year‑old female who presented with dyspnea upon exertion, a paroxysmal cough, night sweats and recurrent pericardial effusion. The patient was diagnosed with tuberculous pericarditis and received antituberculous drug therapy. Echocardiography and magnetic resonance imaging (MRI) revealed a pericardial mass lying predominantly over the right atrium. The patient was treated by surgical excision and a subsequent histological analysis confirmed the diagnosis of a pericardial synovial sarcoma. Under high power examination, a characteristic biphasic appearance consisting of hypercellular spindled cell sheets was observed. Immunohistochemistry demonstrated positive staining for epithelial membrane antigen (EMA), vimentin and Bcl 2. The patient was then referred for adjuvant chemotherapy with a combination of adriamycin and ifosfamide. The patient has since remained clinically free of disease for 32 months.
View References
|
1
|
Al-Rajhi N, Husain S, Coupland R, McNamee
C and Jha N: Primary pericardial synovial sarcoma: a case report
and literature review. J Surg Oncol. 70:194–198. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
O’Sullivan PJ, Harris AC and Munk PL:
Radiological features of synovial cell sarcoma. Br J Radiol.
81:346–356. 2008.
|
|
3
|
Van der Mieren G, Willems S, Sciot R, et
al: Pericardial synovial sarcoma: 14-year survival with
multimodality therapy. Ann Thorac Surg. 78:e41–e42. 2004.PubMed/NCBI
|
|
4
|
Moorjani N, Peebles C, Gallagher P and
Tsang G: Pericardial synovial sarcoma. J Card Surg. 24:349–351.
2009. View Article : Google Scholar
|
|
5
|
de Zwaan C, Bekkers SC, van Garsse LA,
Jansen RL and van Suylen RJ: Primary monophasic mediastinal,
cardiac and pericardial synovial sarcoma: a young man in distress.
Neth Heart J. 15:226–228. 2007.PubMed/NCBI
|
|
6
|
Schumann C, Kunze M, Kochs M, Hombach V
and Rasche V: Pericardial synovial sarcoma mimicking pericarditis
in findings of cardiac magnetic resonance imaging. Int J Cardiol.
118:e83–e84. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Anand AK, Khanna A, Sinha SK, Mukherjee U,
Walia JS and Singh AN: Pericardial synovial sarcoma. Clin Oncol (R
Coll Radiol). 15:186–188. 2003. View Article : Google Scholar
|
|
8
|
Akerström F, Santos B, Alguacil AM,
Orradre JL, Lima P and Zapardiel S: Pericardial synovial sarcoma.
Thorac Cardiovasc Surg. 59:175–177. 2011.
|
|
9
|
Oizumi S, Igarashi K, Takenaka T, et al:
Primary pericardial synovial sarcoma with detection of the chimeric
transcript SYT-SSX. Jpn Circ J. 63:330–332. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Burke AP, Cowan D and Virmani R: Primary
sarcomas of the heart. Cancer. 69:387–395. 1992. View Article : Google Scholar
|
|
11
|
Clark J, Rocques PJ, Crew AJ, et al:
Identification of novel genes, SYT and SSX, involved in the
t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma.
Nat Genet. 7:502–508. 1994. View Article : Google Scholar : PubMed/NCBI
|
