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Article

α‑Mangostin suppresses lipopolysaccharide‑induced invasion by inhibiting matrix metalloproteinase‑2/9 and increasing E‑cadherin expression through extracellular signal‑regulated kinase signaling in pancreatic cancer cells

  • Authors:
    • Jiangtao Yuan
    • Yaolu Wu
    • Guifang Lu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Affiliated Hospital of Yan'an University, Yan'an, Shaanxi 716000, P.R. China, Department of Gastroenterology, The First Affiliated Hospital of Medical College, Xi'an Jiao Tong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 1958-1964
    |
    Published online on: April 4, 2013
       https://doi.org/10.3892/ol.2013.1290
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Abstract

Invasion and metastasis are major factors in the poor prognosis of pancreatic cancer, which remains one of the most aggressive and lethal diseases worldwide. α‑mangostin, a major xanthone compound identified in the pericarp of mangosteen (Garcinia mangostana, Linn; GML), possesses unique biological activities, including antioxidant, antitumor and anti‑inflammatory effects. Whether α‑mangostin is able to inhibit the invasive ability of pancreatic cancer cells has not been elucidated. In the present study, α‑mangostin was shown to inhibit the invasive ability of the pancreatic cancer cell lines MIAPaCa‑2 and BxPC‑3. The results showed that α‑mangostin inhibited the growth of the pancreatic cancer cells in a dose‑ and time‑dependent manner. At concentrations of <5 µM, α‑mangostin had no significant effects on cytotoxicity, but significantly inhibited the invasion and migration of pancreatic cancer cells and the expression of matrix metalloproteinase (MMP)‑2 and MMP‑9, while increasing the expression of E‑cadherin. The present data also showed that α‑mangostin exerted an inhibitory effect on the phosphorylation of extracellular‑signal‑regulated kinase (ERK). Furthermore, the reduction of ERK phosphorylation by small interfering RNA (siRNA) potentiated the effect of α‑mangostin. Taken together, the data suggest that α‑mangostin inhibited the invasion and metastasis of pancreatic cancer cells by reducing MMP‑2 and MMP‑9 expression, increasing E‑cadherin expression and suppressing the ERK signaling pathway. The present study suggests that α‑mangostin may be a promising agent against pancreatic cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Yuan J, Wu Y and Lu G: α‑Mangostin suppresses lipopolysaccharide‑induced invasion by inhibiting matrix metalloproteinase‑2/9 and increasing E‑cadherin expression through extracellular signal‑regulated kinase signaling in pancreatic cancer cells. Oncol Lett 5: 1958-1964, 2013.
APA
Yuan, J., Wu, Y., & Lu, G. (2013). α‑Mangostin suppresses lipopolysaccharide‑induced invasion by inhibiting matrix metalloproteinase‑2/9 and increasing E‑cadherin expression through extracellular signal‑regulated kinase signaling in pancreatic cancer cells. Oncology Letters, 5, 1958-1964. https://doi.org/10.3892/ol.2013.1290
MLA
Yuan, J., Wu, Y., Lu, G."α‑Mangostin suppresses lipopolysaccharide‑induced invasion by inhibiting matrix metalloproteinase‑2/9 and increasing E‑cadherin expression through extracellular signal‑regulated kinase signaling in pancreatic cancer cells". Oncology Letters 5.6 (2013): 1958-1964.
Chicago
Yuan, J., Wu, Y., Lu, G."α‑Mangostin suppresses lipopolysaccharide‑induced invasion by inhibiting matrix metalloproteinase‑2/9 and increasing E‑cadherin expression through extracellular signal‑regulated kinase signaling in pancreatic cancer cells". Oncology Letters 5, no. 6 (2013): 1958-1964. https://doi.org/10.3892/ol.2013.1290
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan J, Wu Y and Lu G: α‑Mangostin suppresses lipopolysaccharide‑induced invasion by inhibiting matrix metalloproteinase‑2/9 and increasing E‑cadherin expression through extracellular signal‑regulated kinase signaling in pancreatic cancer cells. Oncol Lett 5: 1958-1964, 2013.
APA
Yuan, J., Wu, Y., & Lu, G. (2013). α‑Mangostin suppresses lipopolysaccharide‑induced invasion by inhibiting matrix metalloproteinase‑2/9 and increasing E‑cadherin expression through extracellular signal‑regulated kinase signaling in pancreatic cancer cells. Oncology Letters, 5, 1958-1964. https://doi.org/10.3892/ol.2013.1290
MLA
Yuan, J., Wu, Y., Lu, G."α‑Mangostin suppresses lipopolysaccharide‑induced invasion by inhibiting matrix metalloproteinase‑2/9 and increasing E‑cadherin expression through extracellular signal‑regulated kinase signaling in pancreatic cancer cells". Oncology Letters 5.6 (2013): 1958-1964.
Chicago
Yuan, J., Wu, Y., Lu, G."α‑Mangostin suppresses lipopolysaccharide‑induced invasion by inhibiting matrix metalloproteinase‑2/9 and increasing E‑cadherin expression through extracellular signal‑regulated kinase signaling in pancreatic cancer cells". Oncology Letters 5, no. 6 (2013): 1958-1964. https://doi.org/10.3892/ol.2013.1290
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