Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June 2013 Volume 5 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June 2013 Volume 5 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Reversion‑inducing cysteine‑rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma

  • Authors:
    • Xia Mao
    • Longlong Liu
    • Bing Zhang
    • Donghua Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
  • Pages: 1867-1871
    |
    Published online on: April 16, 2013
       https://doi.org/10.3892/ol.2013.1306
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The reversion‑inducing cysteine‑rich protein with Kazal motifs (RECK) gene was originally identified as a transformation suppressor gene that is widely expressed in normal tissues. In tumor tissues, RECK expression levels are significantly reduced, and the downregulation of RECK has been implicated in tumors that are more aggressive with a poor prognosis. In the present study, RECK expression in peripheral T‑cell lymphoma (PTCL; n=82) was examined using immunohistochemistry, and its correlation with clinicopathological factors was analyzed. According to the proportion of positively‑stained cells and the staining intensity (SI), the patients were categorized into RECK‑negative or RECK‑positive groups. RECK expression was observed in 30 of the 82 patients (36.6%). The 3‑year survival rate of the patients with RECK‑positive tumors (65.5%) was significantly high compared with that of the patients with RECK‑negative tumors (20.3%; P=0.046). Reduced RECK expression was found to be significantly correlated with extranodal lymphomatous involvement (P=0.012). The survival analysis showed that RECK‑negative expression was an independent and significant factor for predicting a poor prognosis. RECK status is a useful prognostic factor for assessing the biological behavior in PTCL.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Lennert K and Feller AC: The diagnosis of lymphoma. Histopathology of Non-Hodgkin’s Lymphomas (Based on the Updated Kiel Classification). 2nd edition. Berlin: Springer-Verlag; pp. 1–6. 1992

2 

Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, et al: A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 84:1361–1392. 1994.PubMed/NCBI

3 

Jaffe ES, Harris NL, Stein H and Vardiman JW: Pathology and genetics of tumours of haematopoetic and lymphphoid tissues. WHO Classification of Tumours. Kleihues P and Sobin LH: 3. 1st edition. Lyon, France: IARC Press; pp. 1–351. 2001

4 

Pileri S, Ralfkiaer E, Weisenburger D, et al: Peripheral T-cell lymphoma, not otherwise specified. WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. Swerdlow S, Campo E, Harris NL, et al: 4th edition. Lyon: IARC; pp. 4292008

5 

Vose J, Armitage J and Weisenburger D; International T-Cell Lymphoma Project: International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol. 26:4124–4130. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Su IJ, Wang CH, Cheng AL, Chen YC, Hsieh HC, Chen CJ, Tien HF, Woei-Tsay, Huang SS, Hu CY, et al: Characterization of the spectrum of postthymic T-cell malignancies in Taiwan. A clinicopathologic study of HTLV-l-positive and HTLV-l-negative cases. Cancer. 61:2060–2070. 1988. View Article : Google Scholar : PubMed/NCBI

7 

Takagi N, Nakamura S, Ueda R, Osada H, Obata Y, Kitoh K, Suchi T and Takahashi T: A phenotypic and genotypic study of three node-based, low-grade peripheral T-cell lymphomas: angioimmunoblastic lymphoma, T-zone lymphoma, and lymphoepithelioid lymphoma. Cancer. 69:2571–2582. 1992. View Article : Google Scholar : PubMed/NCBI

8 

Nakamura S, Suchi T, Koshikaua T, Suzuki H, Oyama A, Kojima M, Motoori T, Ueda R and Takahashi T: Clinicopathologic study of 212 cases of peripheral T-cell lymphoma among the Japanese. Cancer. 72:1762–1772. 1993. View Article : Google Scholar : PubMed/NCBI

9 

López-Guillermo A, Cid J, Salar A, López A, Montalbán C, Castrillo JM, González M, Ribera JM, Brunet S, García-Conde J, Fernández de Sevilla A, Bosch F and Montserrat E: Peripheral T-cell lymphomas: initial features, natural history, and prognostic factors in a series of 174 patients diagnosed according to the R.E.A.L. Classification. Ann Oncol. 9:849–855. 1998.PubMed/NCBI

10 

Gisselbrecht C, Gaulard P, Lepage E, Coiffier B, Brière J, Haioun C, Cazals-Hatem D, Bosly A, Xerri L, Tilly H, Berger F, Bouhabdallah R and Diebold J: Prognostic significance of T-cell phenotype in aggressive non-Hodgkin’s lymphomas. Groupe d’Etudes des Lymphomes de l’Adulte (GELA). Blood. 92:76–82. 1998.

11 

No authors listed:. Effect of age on the characteristics and clinical behavior of non-Hodgkin’s lymphoma patients. The Non-Hodgkin’s Lymphoma Classification Project. Ann Oncol. 8:973–978. 1997.

12 

Takahashi C, Sheng Z, Horan TP, Kitayama H, Maki M, Hitomi K, Kitaura Y, Takai S, Sasahara RM, Horimoto A, Ikawa Y, Ratzkin BJ, Arakawa T and Noda M: Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane anchored glycoprotein RECK. Proc Natl Acad Sci USA. 95:13221–13226. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Oh J, Takahashi R, Kondo S, Mizoguchi A, Adachi E, Sasahara RM, Imamura Y, Kitayama H, Alexander DB, Ide C, Horan TP, Arakawa T, Yoshida H, Nishikawa S, Itoh Y, Seiki M, Itohara S, Takahashi C and Noda M: The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell. 107:789–800. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Masui T, Doi R, Koshiba T, Fujimoto K, Tsuji S, Nakajima S, Koizumi M, Toyoda E, Tulachan S, Ito D, Kami K, Mori T, Wada M, Noda M and Imamura M: RECK expression in pancreatic cancer: its correlation with lower invasiveness and better prognosis. Clin Cancer Res. 9:1779–1784. 2003.PubMed/NCBI

15 

Furumoto K, Arii S, Mori A, Furuyama H, Gorrin Rivas MJ, Nakao T, Isobe N, Murata T, Takahashi C, Noda M and Imamura M: RECK gene expression in hepatocellular carcinoma: correlation with invasion-related clinicopathological factors and its clinical significance. Reverse inducing - cysteine rich protein with Kazal motifs. Hepatology. 33:189–195. 2001. View Article : Google Scholar

16 

Span PN, Sweep CG, Manders P, Beex LV, Leppert D and Lindberg RL: Matrix metalloproteinase inhibitor reversion-inducing cysteine-rich protein with Kazal motifs: a prognostic marker for good clinical outcome in human breast carcinoma. Cancer. 97:2710–2715. 2003. View Article : Google Scholar

17 

Takenaka K, Ishikawa S, Kawano Y, Yanagihara K, Miyahara R, Otake Y, Morioka Y, Takahashi C, Noda M, Wada H and Tanaka F: Expression of a novel matrix metalloproteinase regulator, RECK, and its clinical significance in resected non-small cell lung cancer. Eur J Cancer. 40:1617–1623. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Takeuchi T, Hisanaga M, Nagao M, Ikeda N, Fujii H, Koyama F, Mukogawa T, Matsumoto H, Kondo S, Takahashi C, Noda M and Nakajima Y: The membrane-anchored matrix metalloproteinase (MMP) regulator RECK in combination with MMP-9 serves as an informative prognostic indicator for colorectal cancer. Clin Cancer Res. 10:5572–5579. 2004. View Article : Google Scholar

19 

Li Y, Zhang Y and Zheng Q: Expression of RECK gene and MMP-9 in hilar cholangiocarcinoma and its clinical significance. J Huazhong Univ Sci Technolog Med Sci. 25:552–554. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA and Bloomfield CD: The World Health Organization classification of neoplastic diseaes of the hematopietic and lymphoid tissues. Report of the Clinical Advisor Committee meeting, Airlie House, Virginia, November 1997. Ann Oncol. 10:1419–1432. 1999. View Article : Google Scholar

21 

No author listed:. A predictive model for aggressive non-Hodgkin’s lymphoma. The International Non-Hodgkin’s Lymphoma Prognostic Factors Project. N Engl J Med. 329:987–994. 1993.

22 

Friedrichs K, Gluba S, Eidtmann H and Jonat W: Overexpression of p53 and prognosis in breast cancer. Cancer. 72:3641–3647. 1993. View Article : Google Scholar : PubMed/NCBI

23 

Melnyk A, Rodriguez A, Pugh WC and Cabannillas F: Evaluation of the Revised European-American Lymphoma classification confirms the clinical relevance of immunophenotype in 560 cases of aggressive non-Hodgkin’s lymphoma. Blood. 89:4514–4520. 1997.PubMed/NCBI

24 

Savage KJ, Chhanabhai M, Gascoyne RD and Connors JM: Characterization of peripheral T-cell lymphomas in a single North American institution by the WHO classification. Ann Oncol. 15:1467–1475. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Gallamini A, Stelitano C, Calvi R, Bellei M, Mattei D, Vitolo U, Morabito F, Martelli M, Brusamolino E, Iannitto E, Zaja F, Cortelazzo S, Rigacci L, Devizzi L, Todeschini G, Santini G, Brugiatelli M and Federico M; Intergruppo Italiano Linfomi: Peripheral T-cell lymphoma unspecified (PTCL-U): a new prognostic model from a retrospective multicentric clinical study. Blood. 103:2474–2479. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Cheung MM, Chan JK, Lau WH, Foo W, Chan PT, Ng CS and Ngan RK: Primary non-Hodgkin’s lymphoma of the nose and nasopharynx: clinical features, tumor immunophenotype, and treatment outcome in 113 patients. J Clin Oncol. 16:70–77. 1998.

27 

Chim CS, Ma SY, Au WY, Choy C, Lie AK, Liang R, Yau CC and Kwong YL: Primary nasal natural killer cell lymphoma: long-term treatment outcome and relationship with the International Prognostic Index. Blood. 103:216–221. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Piccaluga PP, Agostinelli C, Gazzola A, Mannu C, Bacci F, Sabattini E and Pileri SA: Prognostic markers in peripheral T-cell lymphoma. Curr Hematol Malig Rep. 5:222–228. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Sasahara RM, Takahashi C and Noda M: Involvement of the Sp1 site in ras-mediated downregulation of the RECK metastasis suppressor gene. Biochem Biophys Res Commun. 264:668–675. 1999. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Mao X, Liu L, Zhang B and Zhang D: Reversion‑inducing cysteine‑rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma. Oncol Lett 5: 1867-1871, 2013.
APA
Mao, X., Liu, L., Zhang, B., & Zhang, D. (2013). Reversion‑inducing cysteine‑rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma. Oncology Letters, 5, 1867-1871. https://doi.org/10.3892/ol.2013.1306
MLA
Mao, X., Liu, L., Zhang, B., Zhang, D."Reversion‑inducing cysteine‑rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma". Oncology Letters 5.6 (2013): 1867-1871.
Chicago
Mao, X., Liu, L., Zhang, B., Zhang, D."Reversion‑inducing cysteine‑rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma". Oncology Letters 5, no. 6 (2013): 1867-1871. https://doi.org/10.3892/ol.2013.1306
Copy and paste a formatted citation
x
Spandidos Publications style
Mao X, Liu L, Zhang B and Zhang D: Reversion‑inducing cysteine‑rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma. Oncol Lett 5: 1867-1871, 2013.
APA
Mao, X., Liu, L., Zhang, B., & Zhang, D. (2013). Reversion‑inducing cysteine‑rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma. Oncology Letters, 5, 1867-1871. https://doi.org/10.3892/ol.2013.1306
MLA
Mao, X., Liu, L., Zhang, B., Zhang, D."Reversion‑inducing cysteine‑rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma". Oncology Letters 5.6 (2013): 1867-1871.
Chicago
Mao, X., Liu, L., Zhang, B., Zhang, D."Reversion‑inducing cysteine‑rich protein with Kazal motifs gene expression and its clinical significance in peripheral T-cell lymphoma". Oncology Letters 5, no. 6 (2013): 1867-1871. https://doi.org/10.3892/ol.2013.1306
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team