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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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July 2013 Volume 6 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Phosphorylation of estrogen receptor α at serine 118 is correlated with breast cancer resistance to tamoxifen

  • Authors:
    • Ming Chen
    • Yu-Kun Cui
    • Wen-He Huang
    • Kwan Man
    • Guo-Jun Zhang
  • View Affiliations / Copyright

    Affiliations: Breast Center of The Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 515031, P.R. China , The Central Laboratory of The Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong 515031, P.R. China, Department of Surgery, Li Ka-Shing Faculty of Medicine, Hong Kong University, Hong Kong, SAR, P.R. China
  • Pages: 118-124
    |
    Published online on: April 29, 2013
       https://doi.org/10.3892/ol.2013.1324
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Abstract

The aim of the present study was to explore the correlation between estrogen receptor α (ERα) phosphorylation at serines 118 and 167 and the responsiveness of patients with primary breast cancer to tamoxifen. Tumors from 104 patients with primary breast cancer who received adjuvant tamoxifen therapy at The Affiliated Cancer Hospital of Shantou University Medical College between January 2001 to December 2007 were subjected to immunohistochemical analysis with specific antibodies against ERα phosphorylated at either serine 118 (pERα‑S118) and/or serine 167 (pERα‑S167). ERα phosphorylation at the two sites was correlated with either the disease-free survival or the overall survival rate of these patients using the Kaplan-Meier survival analysis. pERα-S118 and pERα‑S167 were found to be expressed in the cell nucleus of 25.0% (26/104) and 26.9% (28/104) of breast cancers, respectively. The expression of pERα-S118 was positively correlated with the human epidermal growth factor receptor-2 (HER-2) status (χ2=6.85, P=0.01). The Kaplan‑Meier analysis revealed a poorer disease-free (P=0.022) and overall survival (P=0.013) in breast cancer patients expressing pERα‑S118, but not in those expressing pERα-S167. In conclusion, pERα‑S118 was correlated with the HER-2 status and predicted breast cancer resistance to tamoxifen.
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Copy and paste a formatted citation
Spandidos Publications style
Chen M, Cui Y, Huang W, Man K and Zhang G: Phosphorylation of estrogen receptor α at serine 118 is correlated with breast cancer resistance to tamoxifen. Oncol Lett 6: 118-124, 2013.
APA
Chen, M., Cui, Y., Huang, W., Man, K., & Zhang, G. (2013). Phosphorylation of estrogen receptor α at serine 118 is correlated with breast cancer resistance to tamoxifen. Oncology Letters, 6, 118-124. https://doi.org/10.3892/ol.2013.1324
MLA
Chen, M., Cui, Y., Huang, W., Man, K., Zhang, G."Phosphorylation of estrogen receptor α at serine 118 is correlated with breast cancer resistance to tamoxifen". Oncology Letters 6.1 (2013): 118-124.
Chicago
Chen, M., Cui, Y., Huang, W., Man, K., Zhang, G."Phosphorylation of estrogen receptor α at serine 118 is correlated with breast cancer resistance to tamoxifen". Oncology Letters 6, no. 1 (2013): 118-124. https://doi.org/10.3892/ol.2013.1324
Copy and paste a formatted citation
x
Spandidos Publications style
Chen M, Cui Y, Huang W, Man K and Zhang G: Phosphorylation of estrogen receptor α at serine 118 is correlated with breast cancer resistance to tamoxifen. Oncol Lett 6: 118-124, 2013.
APA
Chen, M., Cui, Y., Huang, W., Man, K., & Zhang, G. (2013). Phosphorylation of estrogen receptor α at serine 118 is correlated with breast cancer resistance to tamoxifen. Oncology Letters, 6, 118-124. https://doi.org/10.3892/ol.2013.1324
MLA
Chen, M., Cui, Y., Huang, W., Man, K., Zhang, G."Phosphorylation of estrogen receptor α at serine 118 is correlated with breast cancer resistance to tamoxifen". Oncology Letters 6.1 (2013): 118-124.
Chicago
Chen, M., Cui, Y., Huang, W., Man, K., Zhang, G."Phosphorylation of estrogen receptor α at serine 118 is correlated with breast cancer resistance to tamoxifen". Oncology Letters 6, no. 1 (2013): 118-124. https://doi.org/10.3892/ol.2013.1324
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