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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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July 2013 Volume 6 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Efficacy of combined axitinib with dacarbazine in a B16F1 melanoma xenograft model

  • Authors:
    • Xiao‑Hua Zhang
    • En‑Qi Qiao
    • Zhenzhen Gao
    • Hua‑Qing Yuan
    • Pei‑Fen Cai
    • Xiao‑Min Li
    • Yan‑Hong Gu
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of General Surgery and Research Center for Clinical Oncology, Affiliated Jiangsu Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, P.R. China, Department of Emergency, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu 222000, P.R. China
  • Pages: 69-74
    |
    Published online on: May 14, 2013
       https://doi.org/10.3892/ol.2013.1345
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Abstract

In this study, we evaluated the efficacy and intestinal side effects of the selective inhibitor of vascular endothelial growth factor (VEGF) receptors, axitinib and/or dacarbazine (DTIC), in a B16F1 melanoma xenograft model. C57BL/6 mice were subcutaneously inoculated with B16F1 melanoma cells. The study was randomized into four groups receiving either 0.5% carboxyl methylcellulose, DTIC, axitinib or a combination of DTIC and axitinib. When the experimental period was complete, the tumor tissues from each mouse were excised, photographed and weighed. The tumor and intestinal tissues were harvested with 4% paraformaldehyde, and paraffin‑embedded sections were prepared for hematoxylin and eosin staining, immunohistochemical staining (with antibody specific to proliferating cell nuclear antibody) and terminal deoxynucleotidyl-transferase-mediated dUTP nick end labeling assays. The expression of the VEGF and matrix metalloproteinase 9 genes was analyzed using real‑time polymerase chain reaction. No significant benefit to treatment with a combination of axitinib and DTIC, as opposed to axitinib alone, was observed; however, the combined treatment did not enhance the level of enteritis compared with that observed in the axitinb group. In addition, axitinib, as a single agent, demonstrated an improved treatment efficacy compared with DTIC. Therefore, axitinib represents a potential novel, efficient and safe anticancer agent, suggesting a possible use for this schedule in treating melanomas that are less sensitive to DTIC.
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1. 

Garbe C and Leiter U: Melanoma epidemiology and trends. Clin Dermatol. 27:3–9. 2009. View Article : Google Scholar

2. 

Balch CM, Soong SJ, Gershenwald JE, et al: Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol. 19:3622–3634. 2001.PubMed/NCBI

3. 

Agarwala SS: Current systemic therapy for metastatic melanoma. Expert Rev Anticancer Ther. 9:587–595. 2009. View Article : Google Scholar : PubMed/NCBI

4. 

Bedikian AY, Millward M, Pehamberger H, et al: Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study Group. J Clin Oncol. 24:4738–4745. 2006. View Article : Google Scholar : PubMed/NCBI

5. 

Rini BI, Escudier B, Tomczak P, et al: Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet. 378:1931–1939. 2011. View Article : Google Scholar : PubMed/NCBI

6. 

Rixe O, Bukowski RM, Michaelson MD, et al: Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study. Lancet Oncol. 8:975–984. 2007. View Article : Google Scholar : PubMed/NCBI

7. 

Cohen EE, Rosen LS, Vokes EE, et al: Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study. J Clin Oncol. 26:4708–4713. 2008. View Article : Google Scholar : PubMed/NCBI

8. 

Schiller JH, Larson T, Ou SH, et al: Efficacy and safety of axitinib in patients with advanced non-small-cell lung cancer: results from a phase II study. J Clin Oncol. 27:3836–3841. 2009. View Article : Google Scholar : PubMed/NCBI

9. 

Hersey P, Bastholt L, Chiarion-Sileni V, et al: Small molecules and targeted therapies in distant metastatic disease. Ann Oncol. 20(Suppl 6): vi35–vi40. 2009. View Article : Google Scholar : PubMed/NCBI

10. 

Hu-Lowe DD, Zou HY, Grazzini ML, et al: Nonclinical anti-angiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor tyrosine kinases 1, 2, 3. Clin Cancer Res. 14:7272–7283. 2008. View Article : Google Scholar : PubMed/NCBI

11. 

Fruehauf J, Lutzky J, McDermott D, et al: Multicenter, phase II study of axitinib, a selective second-generation inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, in patients with metastatic melanoma. Clin Cancer Res. 17:7462–7469. 2011. View Article : Google Scholar

12. 

Emmett MS, Dewing D and Pritchard-Jones RO: Angiogenesis and melanoma - from basic science to clinical trials. Am J Cancer Res. 1:852–868. 2011.PubMed/NCBI

13. 

Ma J and Waxman DJ: Dominant effect of antiangiogenesis in combination therapy involving cyclophosphamide and axitinib. Clin Cancer Res. 15:578–588. 2009. View Article : Google Scholar : PubMed/NCBI

14. 

Ma J and Waxman DJ: Modulation of the antitumor activity of metronomic cyclophosphamide by the angiogenesis inhibitor axitinib. Mol Cancer Ther. 7:79–89. 2008. View Article : Google Scholar : PubMed/NCBI

15. 

Richardson, G and Dobish R: Chemotherapy induced diarrhea. J Oncol Pharm Pract. 13:181–198. 2007. View Article : Google Scholar

16. 

Jemal A, Siegel R, Xu J and Ward E: Cancer statistics, 2010. CA Cancer J Clin. 60:277–300. 2010. View Article : Google Scholar

17. 

Wilmes LJ, Pallavicini MG, Fleming LM, et al: AG-013736, a novel inhibitor of VEGF receptor tyrosine kinases, inhibits breast cancer growth and decreases vascular permeability as detected by dynamic contrast-enhanced magnetic resonance imaging. Magn Reson Imaging. 25:319–327. 2007. View Article : Google Scholar

18. 

Nakahara T, Norberg SM, Shalinsky DR, Hu-Lowe DD and McDonald DM: Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors. Cancer Res. 66:1434–1445. 2006. View Article : Google Scholar : PubMed/NCBI

19. 

Spano JP, Chodkiewicz C, Maurel J, et al: Efficacy of gemcitabine plus axitinib compared with gemcitabine alone in patients with advanced pancreatic cancer: an open-label randomised phase II study. Lancet. 371:2101–2108. 2008. View Article : Google Scholar : PubMed/NCBI

20. 

Kindler HL, Ioka T, Richel DJ, et al: Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study. Lancet Oncol. 12:256–262. 2011. View Article : Google Scholar : PubMed/NCBI

21. 

Rugo HS, Stopeck AT, Joy AA, et al: Randomized, placebo-controlled, double-blind, phase II study of axitinib plus docetaxel versus docetaxel plus placebo in patients with meta-static breast cancer. J Clin Oncol. 29:2459–2465. 2011. View Article : Google Scholar : PubMed/NCBI

22. 

Bendell JC, Tournigand C, Bednarczyk M, et al: Axitinib or bevacizumab (bev) plus FOLFOX or FOLFIRI as second-line therapy in patients (pts) with metastatic colorectal cancer (mCRC). J Clin Oncol. 29(suppl 4): abstr 478. 2011.

23. 

Hiratsuka S, Nakamura K, Iwai S, et al: MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Cancer Cell. 2:289–300. 2002. View Article : Google Scholar : PubMed/NCBI

24. 

Shafi MA and Bresalier RS: The gastrointestinal complications of oncologic therapy. Gastroenterol Clin North Am. 39:629–647. 2010. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang XH, Qiao EQ, Gao Z, Yuan HQ, Cai PF, Li XM and Gu YH: Efficacy of combined axitinib with dacarbazine in a B16F1 melanoma xenograft model. Oncol Lett 6: 69-74, 2013.
APA
Zhang, X., Qiao, E., Gao, Z., Yuan, H., Cai, P., Li, X., & Gu, Y. (2013). Efficacy of combined axitinib with dacarbazine in a B16F1 melanoma xenograft model. Oncology Letters, 6, 69-74. https://doi.org/10.3892/ol.2013.1345
MLA
Zhang, X., Qiao, E., Gao, Z., Yuan, H., Cai, P., Li, X., Gu, Y."Efficacy of combined axitinib with dacarbazine in a B16F1 melanoma xenograft model". Oncology Letters 6.1 (2013): 69-74.
Chicago
Zhang, X., Qiao, E., Gao, Z., Yuan, H., Cai, P., Li, X., Gu, Y."Efficacy of combined axitinib with dacarbazine in a B16F1 melanoma xenograft model". Oncology Letters 6, no. 1 (2013): 69-74. https://doi.org/10.3892/ol.2013.1345
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang XH, Qiao EQ, Gao Z, Yuan HQ, Cai PF, Li XM and Gu YH: Efficacy of combined axitinib with dacarbazine in a B16F1 melanoma xenograft model. Oncol Lett 6: 69-74, 2013.
APA
Zhang, X., Qiao, E., Gao, Z., Yuan, H., Cai, P., Li, X., & Gu, Y. (2013). Efficacy of combined axitinib with dacarbazine in a B16F1 melanoma xenograft model. Oncology Letters, 6, 69-74. https://doi.org/10.3892/ol.2013.1345
MLA
Zhang, X., Qiao, E., Gao, Z., Yuan, H., Cai, P., Li, X., Gu, Y."Efficacy of combined axitinib with dacarbazine in a B16F1 melanoma xenograft model". Oncology Letters 6.1 (2013): 69-74.
Chicago
Zhang, X., Qiao, E., Gao, Z., Yuan, H., Cai, P., Li, X., Gu, Y."Efficacy of combined axitinib with dacarbazine in a B16F1 melanoma xenograft model". Oncology Letters 6, no. 1 (2013): 69-74. https://doi.org/10.3892/ol.2013.1345
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