Effect of DLK1 on tumorigenesis in CD34+CD38- bone marrow cells in myelodysplastic syndromes

Zhang,Wei; Shao,Zonghong; Fu,Rong; Wang,Huaquan; Li,Lijuan; Yue,Lanzhu

doi:10.3892/ol.2013.1346

July 2013 Volume 6 Issue 1

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July 2013 Volume 6 Issue 1

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Article

Effect of DLK1 on tumorigenesis in CD34+CD38- bone marrow cells in myelodysplastic syndromes

Authors:
- Wei Zhang
- Zonghong Shao
- Rong Fu
- Huaquan Wang
- Lijuan Li
- Lanzhu Yue
View Affiliations / Copyright

Affiliations: Department of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052, P.R. China
Pages: 203-206
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Published online on: May 14, 2013

https://doi.org/10.3892/ol.2013.1346
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Abstract

The myelodysplastic syndromes (MDSs) are a group of clonal stem cell disorders resulting from aberrations within hematopoietic stem cells (HSCs), which may lead to the onset of a number of diseases, including acute myeloid leukemia (AML). Recent studies have demonstrated that the expression levels of the DLK1 gene are increased in MDS. In order to determine whether the addition of DLK1 affects tumorigenesis, small interfering (si)RNAs were designed to target DLK1 in order to knockdown its expression in CD34+CD38- bone marrow cells in MDS. A lower proliferative rate was observed in the CD34+CD38- bone marrow cells following this knockdown of DLK1 expression. The suppression of DLK1 expression resulted in a less aggressive MDS phenotype, which suggests that the upregulation of DLK1 expression may play an oncogenic role in CD34+CD38- bone marrow cells.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Effect of DLK1 on tumorigenesis in CD34+CD38- bone marrow cells in myelodysplastic syndromes

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