Gene expression analysis of aberrant signaling pathways in meningiomas

Torres‑Martín,Miguel; Martinez‑Glez,Victor; Peña‑Granero,Carolina; Isla,Alberto; Lassaletta,Luis; De Campos,Jose  M.; Pinto,Giovanny  R.; Burbano,Rommel  R.; Meléndez,Bárbara; Castresana,Javier  S.; Rey,Juan  A.

doi:10.3892/ol.2013.1363

July 2013 Volume 6 Issue 1

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July 2013 Volume 6 Issue 1

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Article

Gene expression analysis of aberrant signaling pathways in meningiomas

Authors:
- Miguel Torres‑Martín
- Victor Martinez‑Glez
- Carolina Peña‑Granero
- Alberto Isla
- Luis Lassaletta
- Jose M. De Campos
- Giovanny R. Pinto
- Rommel R. Burbano
- Bárbara Meléndez
- Javier S. Castresana
- Juan A. Rey
View Affiliations / Copyright

Affiliations: Neuro-Oncogenetics Laboratory, Research Unit, La Paz University Hospital, IdiPAZ, Madrid, Spain, INGEMM, La Paz University Hospital, IdiPAZ, Madrid, Spain, Neurosurgery Department, La Paz University Hospital, IdiPAZ, Madrid, Spain, Department of Otolaryngology, La Paz University Hospital, IdiPAZ, Madrid, Spain, Fundación Jiménez Díaz, Madrid, Spain, Genetics and Molecular Biology Laboratory, Federal University of Piauí, Parnaibá, Brazil, Human Cytogenetics Laboratory, Federal University of Pará, Belem, Brazil, Molecular Pathology Research Unit, Virgen de la Salud Hospital, Toledo, Spain, Brain Tumor Biology Unit, University of Navarra, Pamplona, Spain
Pages: 275-279
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Published online on: May 23, 2013

https://doi.org/10.3892/ol.2013.1363
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Abstract

Examining aberrant pathway alterations is one method for understanding the abnormal signals that are involved in tumorigenesis and tumor progression. In the present study, expression arrays were performed on tumor‑related genes in meningiomas. The GE Array Q Series HS‑006 was used to determine the expression levels of 96 genes that corresponded to six primary biological regulatory pathways in a series of 42 meningiomas, including 32 grade I, four recurrent grade I and six grade II tumors, in addition to three normal tissue controls. Results showed that 25 genes that were primarily associated with apoptosis and angiogenesis functions were downregulated and 13 genes frequently involving DNA damage repair functions were upregulated. In addition to the inactivation of the neurofibromin gene, NF2, which is considered to be an early step in tumorigenesis, variations of other biological regulatory pathways may play a significant role in the development of meningioma.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Gene expression analysis of aberrant signaling pathways in meningiomas

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Abstract

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