Recurrence and histological evolution of dysembryoplastic neuroepithelial tumor: A case report and review of the literature

Chao,Lv; Tao,Xu  Bo; Jun,Yang  Kai; Xia,Han   Hui; Wan,Wang   Ke; Tao,Qi   Song

doi:10.3892/ol.2013.1480

Recurrence and histological evolution of dysembryoplastic neuroepithelial tumor: A case report and review of the literature

Authors:
- Lv Chao
- Xu Bo Tao
- Yang Kai Jun
- Han Hui Xia
- Wang Ke Wan
- Qi Song Tao
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Affiliations: Department of Neurosurgery, Nan Fang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Pathology, Nan Fang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
Published online on: July 22, 2013 https://doi.org/10.3892/ol.2013.1480
Pages: 907-914

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Abstract

Studies of recurrent dysembryoplastic neuroepithelial tumors (DNTs) are distinctly rare. The present study reports the case of a 15‑year‑old female with a temporal lobe DNT, which recurred and transformed into an astrocytoma (WHO grade II) five years after an initial gross total resection (GTR). Furthermore, all the previous studies on recurrent DNT are reviewed. Although the majority of DNT cases demonstrate benign behavior, recurrent DNTs have been observed following a GTR of the tumor. Patients do not appear to benefit from post‑operative adjuvant therapy, and inappropriate radiotherapy or chemotherapy may result in tumor recurrence or malignant transformation. The prognosis is favorable if a GTR of the recurrent tumor is achieved. The use of regular imaging examinations and the maintenance of a long‑term follow‑up is of importance following a tumor resection.

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1	Daumas-Duport C, Pietsch T and Lantos PL: Dysembryoplastic neuroepithelial tumour. Pathology and Genetics of Tumors of the Nervous System (IARC WHO Classification of Tumors). Kleihues P and Cavenee WK: 2nd edition. IARC Press; Lyon, France: pp. 103–106. 2000
2	Fellah S, Callot V, Viout P, et al: Epileptogenic brain lesions in children: the added-value of combined diffusion imaging and proton MR spectroscopy to the presurgical differential diagnosis. Childs Nerv Syst. 28:273–282. 2012. View Article : Google Scholar
3	Prayson RA and Napekoski KM: Composite ganglioglioma/dysembryoplastic neuroepithelial tumor: a clinicopathologic study of 8 cases. Hum Pathol. 43:1113–1118. 2012. View Article : Google Scholar
4	Thom M, Blümcke I and Aronica E: Long-term epilepsy-associated tumors. Brain Pathol. 22:350–379. 2012. View Article : Google Scholar
5	Nolan MA, Sakuta R, Chuang N, et al: Dysembryoplastic neuroepithelial tumors in childhood: long-term outcome and prognostic features. Neurology. 62:2270–2276. 2004. View Article : Google Scholar : PubMed/NCBI
6	Piao YS, Lu DH, Chen L, et al: Neuropathological findings in intractable epilepsy: 435 Chinese cases. Brain Pathol. 20:902–908. 2010.PubMed/NCBI
7	Sakuta R, Otsubo H, Nolan MA, et al: Recurrent intractable seizures in children with cortical dysplasia adjacent to dysembryoplastic neumepithelial tumor. J Child Neurol. 20:377–384. 2005. View Article : Google Scholar : PubMed/NCBI
8	Duggal N, Taylor R, Zou GY and Hammond RR: Dysembryoplastic neuroepithelial tumors: clinical, proliferative and apoptotic features. J Clin Pathol. 61:127–131. 2008. View Article : Google Scholar : PubMed/NCBI
9	Hammond RR, Duggal N, Woulfe JM and Girvin JP: Malignant transformation of a dysembryoplastic neuroepithelial tumor. Case report. J Neurosurg. 92:722–725. 2000. View Article : Google Scholar : PubMed/NCBI
10	Schittenhelm J, Mittelbronn M, Wolff M, et al: Multifocal dysembryoplastic neuroepithelial tumor with signs of atypia after regrowth. Neuropathology. 27:383–389. 2007. View Article : Google Scholar : PubMed/NCBI
11	Fernandez C, Girard N, Paz Paredes A, et al: The usefulness of MR imaging in the diagnosis of dysembryoplastic neuroepithelial tumor in children: a study of 14 cases. AJNR Am J Neuroradiol. 24:829–834. 2003.PubMed/NCBI
12	Jensen RL, Caamano E, Jensen EM and Couldwell WT: Development of contrast enhancement after long-term observation of a dysembryoplastic neuroepithelial tumor. J Neurooncol. 78:59–62. 2006. View Article : Google Scholar : PubMed/NCBI
13	Maher CO, White JB, Scheithauer BW and Raffel C: Recurrence of dysembryoplastic neuroepithelial tumor following resection. Pediatr Neurosurg. 44:333–336. 2008. View Article : Google Scholar : PubMed/NCBI
14	Ray WZ, Blackburn SL, Casavilca-Zambrano S, et al: Clinicopathologic features of recurrent dysembryoplastic neuroepithelial tumor and rare malignant transformation: a report of 5 cases and review of the literature. J Neurooncol. 94:283–292. 2009. View Article : Google Scholar
15	Rushing EJ, Thompson LD and Mena H: Malignant transformation of a dysembryoplastic neuroepithelial tumor after radiation and chemotherapy. Ann Diagn Pathol. 7:240–244. 2003. View Article : Google Scholar : PubMed/NCBI
16	Thom M, Toma A, An S, et al: One hundred and one dysembryoplastic neuroepithelial tumors: an adult epilepsy series with immunohistochemical, molecular genetic, and clinical correlations and a review of the literature. J Neuropathol Exp Neurol. 70:859–878. 2011. View Article : Google Scholar
17	Zakrzewski K, Biernat W, Liberski PP, Polis L and Nowoslawska E: Pilocytic astrocytoma as a predominant component of a recurrent complex type DNT. Folia Neuropathol. 47:284–288. 2009.PubMed/NCBI
18	Daumas-Duport C, Scheithauer BW, Chodkiewicz JP, et al: Dysembryoplastic neuroepithelial tumor: a surgically curable tumor of young patients with intractable partial seizures. Report of thirty-nine cases. Neurosurgery. 23:545–556. 1988. View Article : Google Scholar
19	Josan V, Smith P, Kornberg A, et al: Development of a pilocytic astrocytoma in a dysembryoplastic neuroepithelial tumor. Case report. J Neurosurg. 106:509–512. 2007.PubMed/NCBI
20	Prayson RA: Tumors arising in the setting of pediatric chronic epilepsy. Pathol. 42:426–431. 2010. View Article : Google Scholar : PubMed/NCBI
21	Prayson RA, Fong J and Najm I: Coexistent pathology in chronic epilepsy patients with neoplasms. Modern Pathol. 23:1097–1103. 2010. View Article : Google Scholar : PubMed/NCBI
22	Dozza DC, Rodrigues FF and Chimelli L: Dysembryoplastic neuroepithelial tumor originally diagnosed as astrocytoma and oligodendroglioma. Arq Neuropsiquiatr. 70:710–714. 2012. View Article : Google Scholar : PubMed/NCBI
23	Gonzales M, Dale S, Susman M, et al: Dysembryoplastic neuroepithelial tumor (DNT)-like oligodendrogliomas or Dnts evolving into oligodendrogliomas: two illustrative cases. Neuropathology. 27:324–330. 2007. View Article : Google Scholar : PubMed/NCBI
24	Minkin K, Klein O, Mancini J and Lena G: Surgical strategies and seizure control in pediatric patients with dysembryoplastic neuroepithelial tumors: a single-institution experience. J Neurosurg Pediatr. 1:206–210. 2008. View Article : Google Scholar
25	Sung CO and Suh YL: Different pattern of expression of nestin in the non-specific form of dysembryoplastic neuroepithelial tumors compared to the simple and complex forms. J Neurooncol. 92:7–13. 2009. View Article : Google Scholar : PubMed/NCBI
26	Lee J, Lee BL, Joo EY, et al: Dysembryoplastic neuroepithelial tumors in pediatric patients. Brain Dev. 31:671–681. 2009. View Article : Google Scholar : PubMed/NCBI
27	Kawataki T, Sato E, Kato T, et al: A cortical dysembryoplastic neuroepithelial tumor initially occurring in the periventricular white matter. J Neurosurg Pediatr. 6:600–603. 2010. View Article : Google Scholar : PubMed/NCBI
28	Qaddoumi I, Ellison DW, Morris EB, et al: Dysembryoplastic neuroepithelial tumors and cognitive outcome: cure at a price? Cancer. 116:5461–5469. 2010. View Article : Google Scholar : PubMed/NCBI
29	Wagner AS, Yin NS, Tung S, et al: Intimal thickening of meningeal arteries after serial corticectomies for Rasmussen encephalitis. Hum Pathol. 43:1308–1313. 2012. View Article : Google Scholar : PubMed/NCBI
30	Ostertun B, Wolf HK, Campos MG, et al: Dysembryoplastic neuroepithelial tumors: MR and CT evaluation. AJNR Am J Neuroradiol. 17:419–430. 1996.PubMed/NCBI
31	Yu AH, Chen L, Li YJ, et al: Dysembryoplastic neuroepithelial tumors: magnetic resonance imaging and magnetic resonance spectroscopy evaluation. Chin Med J (Engl). 122:2433–2437. 2009.PubMed/NCBI