Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
November 2013 Volume 6 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November 2013 Volume 6 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Pro‑apoptotic and migration‑suppressing potential of EGCG, and the involvement of AMPK in the p53‑mediated modulation of VEGF and MMP‑9 expression

  • Authors:
    • Song Yi Park
    • Chang Hee Jung
    • Bokyung Song
    • Ock Jin Park
    • Young‑Min Kim
  • View Affiliations / Copyright

    Affiliations: Department of Biological Sciences and Biotechnology, Hannam University Daedeok Valley Campus, Yuseong‑gu, Daejeon 305‑811, Republic of Korea, Department of Food and Nutrition, Hannam University Daedeok Valley Campus, Yuseong‑gu, Daejeon 305‑811, Republic of Korea
  • Pages: 1346-1350
    |
    Published online on: August 19, 2013
       https://doi.org/10.3892/ol.2013.1533
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study investigated the regulatory mechanisms by which epigallocatechin‑3‑gallate (EGCG) exerts vascular endothelial growth factor (VEGF)‑, p53‑ and AMP‑activated protein kinase (AMPK)‑associated pro‑apoptotic and migration‑suppressing effects on colon cancer cells. EGCG decreased the expression levels of VEGF and matrix metalloproteinase (MMP)‑9. EGCG treatment induced apoptosis in the presence of wild‑type and mutant p53, indicating that a p53‑independent pathway may contribute to EGCG‑induced apoptosis in these cells. EGCG showed migration‑suppressing effects, suggesting that this activity may also have p53‑dependent and ‑independent components. The interaction between p53 and VEGF in the EGCG‑treated cells was investigated using pifithrin‑α. Notably, the suppression of p53 activity blocked the ability of EGCG to inhibit VEGF and MMP‑9 in the cells expressing wild‑type p53, but not mutant p53, indicating that the effects of EGCG on VEGF may be p53‑dependent or ‑independent. Finally, although AMPK and VEGF did not appear to co‑localize, the results indicated that AMPK controls VEGF in EGCG‑treated cells regardless of the p53 status.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar

2 

Murthy NS, Mukherjee S, Ray G and Ray A: Dietary factors and cancer chemoprevention: an overview of obesity-related malignancies. J Postgrad Med. 55:45–54. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Rodrigues NR, Rowan A, Smith ME, Kerr IB, Bodmer WF, Gannon JV and Lane DP: p53 mutations in colorectal cancer. Proc Natl Acad Sci USA. 87:7555–7559. 1990. View Article : Google Scholar : PubMed/NCBI

4 

Yu J and Zhang L: The transcriptional targets of p53 in apoptosis control. Biochem Biophys Res Commun. 331:851–858. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Wang Z and Sun Y: Targeting p53 for Novel Anticancer Therapy. Transl Oncol. 3:1–12. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q, Dillehay LE, Madan A, Semenza GL and Bedi A: Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev. 14:34–44. 2000.PubMed/NCBI

7 

Horiuchi A, Imai T, Shimizu M, Oka K, Wang C, Nikaido T and Konishi I: Hypoxia-induced changes in the expression of VEGF, HIF-1 alpha and cell cycle-related molecules in ovarian cancer cells. Anticancer Res. 22:2697–2702. 2002.PubMed/NCBI

8 

Montero E, Abreu C and Tonino P: Relationship between VEGF and p53 expression and tumor cell proliferation in human gastrointestinal carcinomas. J Cancer Res Clin Oncol. 134:193–201. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Oh SY, Kwon HC, Kim SH, Jang JS, Kim MC, Kim KH, Han JY, Kim CO, Kim SJ, Jeong JS and Kim HJ: Clinicopathologic significance of HIF-1alpha, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer. BMC Cancer. 8:1232008. View Article : Google Scholar : PubMed/NCBI

10 

Dorai T and Aggarwal BB: Role of chemopreventive agents in cancer therapy. Cancer Lett. 215:129–140. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Narayanan BA: Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets. Curr Cancer Drug Targets. 6:711–727. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Guo RP, Zhong C, Shi M, Zhang CQ, Wei W, Zhang YQ and Li JQ: Clinical value of apoptosis and angiogenesis factors in estimating the prognosis of hepatocellular carcinoma. J Cancer Res Clin Oncol. 132:547–555. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Shimizu M, Shirakami Y and Moriwaki H: Targeting receptor tyrosine kinases for chemoprevention by green tea catechin, EGCG. Int J Mol Sci. 9:1034–1049. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Saharinen P, Eklund L, Pulkki K, Bono P and Alitalo K: VEGF and angiopoietin signaling in tumor angiogenesis and metastasis. Trends Mol Med. 17:347–362. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Stetler-Stevenson WG: Type IV collagenases in tumor invasion and metastasis. Cancer Metastasis Rev. 9:289–303. 1990. View Article : Google Scholar : PubMed/NCBI

16 

Liang CC, Park AY and Guan JL: In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc. 2:329–333. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Bouvet M, Ellis LM, Nishizaki M, Fujiwara T, Liu W, Bucana CD, Fang B, Lee JJ and Roth JA: Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer. Cancer Res. 58:2288–2292. 1998.

18 

Hwang JT, Ha J, Park IJ, Lee SK, Baik HW, Kim YM and Park OJ: Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway. Cancer Lett. 247:115–121. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Sartippour MR, Shao ZM, Heber D, Beatty P, Zhang L, Liu C, Ellis L, Liu W, Go VL and Brooks MN: Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells. J Nutr. 132:2307–2311. 2002.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Park SY, Jung CH, Song B, Park OJ and Kim YM: Pro‑apoptotic and migration‑suppressing potential of EGCG, and the involvement of AMPK in the p53‑mediated modulation of VEGF and MMP‑9 expression. Oncol Lett 6: 1346-1350, 2013.
APA
Park, S.Y., Jung, C.H., Song, B., Park, O.J., & Kim, Y. (2013). Pro‑apoptotic and migration‑suppressing potential of EGCG, and the involvement of AMPK in the p53‑mediated modulation of VEGF and MMP‑9 expression. Oncology Letters, 6, 1346-1350. https://doi.org/10.3892/ol.2013.1533
MLA
Park, S. Y., Jung, C. H., Song, B., Park, O. J., Kim, Y."Pro‑apoptotic and migration‑suppressing potential of EGCG, and the involvement of AMPK in the p53‑mediated modulation of VEGF and MMP‑9 expression". Oncology Letters 6.5 (2013): 1346-1350.
Chicago
Park, S. Y., Jung, C. H., Song, B., Park, O. J., Kim, Y."Pro‑apoptotic and migration‑suppressing potential of EGCG, and the involvement of AMPK in the p53‑mediated modulation of VEGF and MMP‑9 expression". Oncology Letters 6, no. 5 (2013): 1346-1350. https://doi.org/10.3892/ol.2013.1533
Copy and paste a formatted citation
x
Spandidos Publications style
Park SY, Jung CH, Song B, Park OJ and Kim YM: Pro‑apoptotic and migration‑suppressing potential of EGCG, and the involvement of AMPK in the p53‑mediated modulation of VEGF and MMP‑9 expression. Oncol Lett 6: 1346-1350, 2013.
APA
Park, S.Y., Jung, C.H., Song, B., Park, O.J., & Kim, Y. (2013). Pro‑apoptotic and migration‑suppressing potential of EGCG, and the involvement of AMPK in the p53‑mediated modulation of VEGF and MMP‑9 expression. Oncology Letters, 6, 1346-1350. https://doi.org/10.3892/ol.2013.1533
MLA
Park, S. Y., Jung, C. H., Song, B., Park, O. J., Kim, Y."Pro‑apoptotic and migration‑suppressing potential of EGCG, and the involvement of AMPK in the p53‑mediated modulation of VEGF and MMP‑9 expression". Oncology Letters 6.5 (2013): 1346-1350.
Chicago
Park, S. Y., Jung, C. H., Song, B., Park, O. J., Kim, Y."Pro‑apoptotic and migration‑suppressing potential of EGCG, and the involvement of AMPK in the p53‑mediated modulation of VEGF and MMP‑9 expression". Oncology Letters 6, no. 5 (2013): 1346-1350. https://doi.org/10.3892/ol.2013.1533
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team