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November 2013 Volume 6 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis

  • Authors:
    • Tian‑Xiao Wang
    • Zhong‑Qing Zhang
    • Yue Cong
    • Xiao‑Yan Shi
    • Ying‑Hua Liu
    • Fang‑Li Zhao
  • View Affiliations / Copyright

    Affiliations: Institute of Traditional Chinese Medicine, College of Pharmacy, Henan University, Kaifeng, Henan 475004, P.R. China
  • Pages: 1323-1328
    |
    Published online on: September 4, 2013
       https://doi.org/10.3892/ol.2013.1561
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Abstract

Signal transducer and activator of transcription 3 (STAT3) is considered to be an oncogene. Blocking STAT3 signaling may induce growth arrest and apoptosis in different types of tumors. Cancer cells utilize the glycolytic pathway to maintain cell growth even when adequate oxygen is present. Glycolysis inhibition is a potential therapeutic modality. In the present study, the effects of Prosapogenin A (PSA) from the traditional Chinese medicine, Veratrum, on apoptosis, the STAT3 signaling pathway and glycometabolism in cancer cells were investigated. The results indicated that PSA induced growth inhibition and apoptosis in HeLa, HepG2 and MCF‑7 cells. PSA inhibited the STAT3 signaling pathway and modulated the expression of glycometabolism‑related genes. The results indicate that the inhibition of the STAT3 signaling and glycometabolism pathways contributes to the PSA‑mediated apoptosis of HeLa, HepG2 and MCF‑7 cells.
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Copy and paste a formatted citation
Spandidos Publications style
Wang TX, Zhang ZQ, Cong Y, Shi XY, Liu YH and Zhao FL: Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis. Oncol Lett 6: 1323-1328, 2013.
APA
Wang, T., Zhang, Z., Cong, Y., Shi, X., Liu, Y., & Zhao, F. (2013). Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis. Oncology Letters, 6, 1323-1328. https://doi.org/10.3892/ol.2013.1561
MLA
Wang, T., Zhang, Z., Cong, Y., Shi, X., Liu, Y., Zhao, F."Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis". Oncology Letters 6.5 (2013): 1323-1328.
Chicago
Wang, T., Zhang, Z., Cong, Y., Shi, X., Liu, Y., Zhao, F."Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis". Oncology Letters 6, no. 5 (2013): 1323-1328. https://doi.org/10.3892/ol.2013.1561
Copy and paste a formatted citation
x
Spandidos Publications style
Wang TX, Zhang ZQ, Cong Y, Shi XY, Liu YH and Zhao FL: Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis. Oncol Lett 6: 1323-1328, 2013.
APA
Wang, T., Zhang, Z., Cong, Y., Shi, X., Liu, Y., & Zhao, F. (2013). Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis. Oncology Letters, 6, 1323-1328. https://doi.org/10.3892/ol.2013.1561
MLA
Wang, T., Zhang, Z., Cong, Y., Shi, X., Liu, Y., Zhao, F."Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis". Oncology Letters 6.5 (2013): 1323-1328.
Chicago
Wang, T., Zhang, Z., Cong, Y., Shi, X., Liu, Y., Zhao, F."Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis". Oncology Letters 6, no. 5 (2013): 1323-1328. https://doi.org/10.3892/ol.2013.1561
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