Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis

Wang,Tian‑Xiao; Zhang,Zhong‑Qing; Cong,Yue; Shi,Xiao‑Yan; Liu,Ying‑Hua; Zhao,Fang‑Li

doi:10.3892/ol.2013.1561

Prosapogenin A induces apoptosis in human cancer cells in vitro via inhibition of the STAT3 signaling pathway and glycolysis

Authors:
- Tian‑Xiao Wang
- Zhong‑Qing Zhang
- Yue Cong
- Xiao‑Yan Shi
- Ying‑Hua Liu
- Fang‑Li Zhao
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Affiliations: Institute of Traditional Chinese Medicine, College of Pharmacy, Henan University, Kaifeng, Henan 475004, P.R. China
Published online on: September 4, 2013 https://doi.org/10.3892/ol.2013.1561
Pages: 1323-1328

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Abstract

Signal transducer and activator of transcription 3 (STAT3) is considered to be an oncogene. Blocking STAT3 signaling may induce growth arrest and apoptosis in different types of tumors. Cancer cells utilize the glycolytic pathway to maintain cell growth even when adequate oxygen is present. Glycolysis inhibition is a potential therapeutic modality. In the present study, the effects of Prosapogenin A (PSA) from the traditional Chinese medicine, Veratrum, on apoptosis, the STAT3 signaling pathway and glycometabolism in cancer cells were investigated. The results indicated that PSA induced growth inhibition and apoptosis in HeLa, HepG2 and MCF‑7 cells. PSA inhibited the STAT3 signaling pathway and modulated the expression of glycometabolism‑related genes. The results indicate that the inhibition of the STAT3 signaling and glycometabolism pathways contributes to the PSA‑mediated apoptosis of HeLa, HepG2 and MCF‑7 cells.

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