Complete remission of a reccurrent mesenteric liposarcoma with rare histological features following the administration of trabectedin

Tsoukalas,N.; Tolia,M.; Lypas,G.; Panopoulos,C.; Barbounis,V.; Koumakis,G.; Efremidis,A.

doi:10.3892/ol.2013.1646

2014-January Volume 7 Issue 1

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2014-January Volume 7 Issue 1

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Article

Complete remission of a reccurrent mesenteric liposarcoma with rare histological features following the administration of trabectedin

Authors:
- N. Tsoukalas
- M. Tolia
- G. Lypas
- C. Panopoulos
- V. Barbounis
- G. Koumakis
- A. Efremidis
View Affiliations / Copyright

Affiliations: 2nd Department of Medical Oncology, ‘Agios Savvas’ Anticancer Hospital, Athens, Ampelokipi 11524, Greece
Pages: 47-49
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Published online on: October 29, 2013

https://doi.org/10.3892/ol.2013.1646
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Abstract

The present study describes a rare case of a mesenteric liposarcoma that resulted in a complete remission (CR) following treatment with trabectedin (Yondelis®). The patient presented with abdominal pain and fever. An abdominal mass was identified that corresponded to a mixed‑type high‑grade mesenteric liposarcoma with wide areas of necrosis, areas of dedifferentiation and features of a leiomyosarcoma. Three months after the removal of the first mass, the patient underwent a second laparotomy, followed by treatment with doxorubicin and ifosfamide. Subsequently, the patient was started on therapy with trabectedin and a CR was noted following only four cycles of therapy. The best responses that are reported in the literature for cases of liposarcoma treated with trabectedin are mostly for liposarcomas of the myxoid/round cell type and are mainly partial responses. In the present study, trabectedin was used for the treatment of a mesenteric liposarcoma of mixed morphological features and a CR was achieved.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Complete remission of a reccurrent mesenteric liposarcoma with rare histological features following the administration of trabectedin

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