Antitumor activities of Juemingzi (Cassia tora L.) on Balb/c sarcoma 180‑injected mice

Chen,Shaocheng; Li,Guijie; Zhu,Kai; Sun,Peng; Wang,Rui; Zhao,Xin

doi:10.3892/ol.2013.1647

2014-January Volume 7 Issue 1

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2014-January Volume 7 Issue 1

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Article

Antitumor activities of Juemingzi (Cassia tora L.) on Balb/c sarcoma 180‑injected mice

Authors:
- Shaocheng Chen
- Guijie Li
- Kai Zhu
- Peng Sun
- Rui Wang
- Xin Zhao
View Affiliations / Copyright

Affiliations: Department of Biological and Chemical Engineering, Chongqing University of Education, Nan'an, Chongqing 400067, P.R. China
Pages: 250-254
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Published online on: October 29, 2013

https://doi.org/10.3892/ol.2013.1647
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Abstract

The antitumor activity of Juemingzi (Cassia tora L.) was investigated in mice that were fed various concentrations of the compound. Although mice fed a low concentration (50 mg/kg b.w.) of Juemingzi exhibited a high tumor weight, the higher feeding concentrations (100 and 200 mg/kg b.w.) were associated with lower weight tumors. The growth rate of mouse splenocytes that were treated with 200 mg/kg b.w. Juemingzi was determined using a 3‑(4,5‑dimethyl‑2‑thiazolyl)‑2,5‑diphenyltetrazolium bromide assay. This rate of proliferation was higher than that achieved with 100 and 50 mg/kg b.w. Juemingzi treatment by fetal bovine serum, lipopolysaccharide or concanavalin A. Compared with the lower concentrations of Juemingzi treatment, 200 mg/kg b.w. Juemingzi significantly (P<0.05) reduced aspartate aminotransferase, alanine transaminase and blood urea nitrogen levels. A high concentration of Juemingzi (200 mg/kg b.w.) significantly (P<0.05) increased the levels of tumor necrosis factor‑α and interleukin‑1β cytokines compared with those of the mice that were treated with 100 and 50 mg/kg b.w. Juemingzi.

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