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2014-January Volume 7 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

VX680 suppresses the growth of HepG2 cells and enhances the chemosensitivity to cisplatin

  • Authors:
    • Rucheng Yao
    • Jun Zheng
    • Weihong Zheng
    • Yuan Gong
    • Wei Liu
    • Rongchun Xing
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First College of Clinical Medical Sciences, Three Gorges University, Yichang, Hubei 443003, P.R. China, Department of Pharmacology, Medical Science College, Three Gorges University, Yichang, Hubei 443003, P.R. China, Department of Respiratory Medicine, The First College of Clinical Medical Sciences, Three Gorges University, Yichang, Hubei 443003, P.R. China
  • Pages: 121-124
    |
    Published online on: October 29, 2013
       https://doi.org/10.3892/ol.2013.1648
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Abstract

VX680 is an Aurora A inhibitor. It has been reported to inhibit the growth of the HepG2 cell line in several studies. However, whether it enhances chemosensitivity to cisplatin remains unclear. In this study, the synergistic effect of VX680 and cisplatin on the proliferation of HepG2 cells was determined by MTT assay. The changes in cell apoptosis were detected by flow cytometry. Aurora A, Bcl‑2 and p53 protein levels were analyzed by western blotting. This study demonstrated that VX680, cisplatin and a combination of the two inhibit the growth of HepG2 cells in a dose‑ and time‑dependent manner. A synergistic effect was observed with the combined therapy. Moreover, the inhibitory effect of VX680 was positively correlated with the expression of Aurora A. The rate of apoptosis in the combined group was significantly higher compared with that of the VX680 and cisplatin groups. In addition, VX680 and cisplatin increased the expression of the p53 protein. Cisplatin reduced the expression of Bcl‑2 protein, while VX680 did not. In the combined group, the expression of Bcl‑2 and p53 changed significantly compared with the single drug group and control group. This study suggests that Aurora A may represent a valid target in hepatocellular carcinoma. We also demonstrated that the Aurora A inhibitor VX680 has a synergistic effect with cisplatin.
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Copy and paste a formatted citation
Spandidos Publications style
Yao R, Zheng J, Zheng W, Gong Y, Liu W and Xing R: VX680 suppresses the growth of HepG2 cells and enhances the chemosensitivity to cisplatin. Oncol Lett 7: 121-124, 2014.
APA
Yao, R., Zheng, J., Zheng, W., Gong, Y., Liu, W., & Xing, R. (2014). VX680 suppresses the growth of HepG2 cells and enhances the chemosensitivity to cisplatin. Oncology Letters, 7, 121-124. https://doi.org/10.3892/ol.2013.1648
MLA
Yao, R., Zheng, J., Zheng, W., Gong, Y., Liu, W., Xing, R."VX680 suppresses the growth of HepG2 cells and enhances the chemosensitivity to cisplatin". Oncology Letters 7.1 (2014): 121-124.
Chicago
Yao, R., Zheng, J., Zheng, W., Gong, Y., Liu, W., Xing, R."VX680 suppresses the growth of HepG2 cells and enhances the chemosensitivity to cisplatin". Oncology Letters 7, no. 1 (2014): 121-124. https://doi.org/10.3892/ol.2013.1648
Copy and paste a formatted citation
x
Spandidos Publications style
Yao R, Zheng J, Zheng W, Gong Y, Liu W and Xing R: VX680 suppresses the growth of HepG2 cells and enhances the chemosensitivity to cisplatin. Oncol Lett 7: 121-124, 2014.
APA
Yao, R., Zheng, J., Zheng, W., Gong, Y., Liu, W., & Xing, R. (2014). VX680 suppresses the growth of HepG2 cells and enhances the chemosensitivity to cisplatin. Oncology Letters, 7, 121-124. https://doi.org/10.3892/ol.2013.1648
MLA
Yao, R., Zheng, J., Zheng, W., Gong, Y., Liu, W., Xing, R."VX680 suppresses the growth of HepG2 cells and enhances the chemosensitivity to cisplatin". Oncology Letters 7.1 (2014): 121-124.
Chicago
Yao, R., Zheng, J., Zheng, W., Gong, Y., Liu, W., Xing, R."VX680 suppresses the growth of HepG2 cells and enhances the chemosensitivity to cisplatin". Oncology Letters 7, no. 1 (2014): 121-124. https://doi.org/10.3892/ol.2013.1648
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