Lentiviral vector‑based therapy in head and neck cancer (Review)

  • Authors:
    • Deepak Upreti
    • Alok Pathak
    • Sam K.P. Kung
  • View Affiliations

  • Published online on: November 1, 2013     https://doi.org/10.3892/ol.2013.1652
  • Pages: 3-9
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Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common neoplasm worldwide. Despite advances in multimodality treatments involving surgery, radiation and chemotherapy, the five‑year survival rate has remained at ~50% for the past 35 years. Therefore, the early detection of recurrent or persistent disease is extremely important. Replication‑incompetent HIV‑1‑based lentiviral vectors have emerged as powerful and safe tools for gene delivery. Commonly, HNSCC is a locoregional disease that presents at or close to the body surface. Thus, HNSCC is amendable to intratumoral injections of gene therapy vectors aimed at correcting defects associated with tumor suppressor genes to induce the direct cytotoxicity of cancer cells or immune modulation to promote antitumor immunity. Current investigations analyzing HNSCC gene mutations and stem cell markers and the cancer immunoediting concept are creating exciting therapeutic opportunities for lentiviral and other gene transfer vectors. The present review reports specific examples of the current applications of lentiviral vectors in HNSCC.
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2014-January
Volume 7 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Upreti D, Pathak A and Kung SK: Lentiviral vector‑based therapy in head and neck cancer (Review). Oncol Lett 7: 3-9, 2014
APA
Upreti, D., Pathak, A., & Kung, S.K. (2014). Lentiviral vector‑based therapy in head and neck cancer (Review). Oncology Letters, 7, 3-9. https://doi.org/10.3892/ol.2013.1652
MLA
Upreti, D., Pathak, A., Kung, S. K."Lentiviral vector‑based therapy in head and neck cancer (Review)". Oncology Letters 7.1 (2014): 3-9.
Chicago
Upreti, D., Pathak, A., Kung, S. K."Lentiviral vector‑based therapy in head and neck cancer (Review)". Oncology Letters 7, no. 1 (2014): 3-9. https://doi.org/10.3892/ol.2013.1652