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2014-January Volume 7 Issue 1

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Review

Lentiviral vector‑based therapy in head and neck cancer (Review)

  • Authors:
    • Deepak Upreti
    • Alok Pathak
    • Sam K.P. Kung
  • View Affiliations / Copyright

    Affiliations: Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E 0T5, Canada, Department of Surgery, Faculty of Medicine, University of Manitoba, Winnipeg, MB R3E 0T5, Canada
  • Pages: 3-9
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    Published online on: November 1, 2013
       https://doi.org/10.3892/ol.2013.1652
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Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common neoplasm worldwide. Despite advances in multimodality treatments involving surgery, radiation and chemotherapy, the five‑year survival rate has remained at ~50% for the past 35 years. Therefore, the early detection of recurrent or persistent disease is extremely important. Replication‑incompetent HIV‑1‑based lentiviral vectors have emerged as powerful and safe tools for gene delivery. Commonly, HNSCC is a locoregional disease that presents at or close to the body surface. Thus, HNSCC is amendable to intratumoral injections of gene therapy vectors aimed at correcting defects associated with tumor suppressor genes to induce the direct cytotoxicity of cancer cells or immune modulation to promote antitumor immunity. Current investigations analyzing HNSCC gene mutations and stem cell markers and the cancer immunoediting concept are creating exciting therapeutic opportunities for lentiviral and other gene transfer vectors. The present review reports specific examples of the current applications of lentiviral vectors in HNSCC.
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1 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Parkin DM, Pisani P and Ferlay J: Global cancer statistics. CA Cancer J Clin. 49:33–64. 1999. View Article : Google Scholar

3 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar

4 

Blot WJ, McLaughlin JK, Winn DM, Austin DF, Greenberg RS, Preston-Martin S, Bernstein L, Schoenberg JB, Stemhagen A and Fraumeni JF Jr: Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res. 48:3282–3287. 1988.PubMed/NCBI

5 

Franceschi S, Talamini R, Barra S, Barón AE, Negri E, Bidoli E, Serraino D and La Vecchia C: Smoking and drinking in relation to cancers of the oral cavity, pharynx, larynx, and esophagus in northern Italy. Cancer Res. 50:6502–6507. 1990.PubMed/NCBI

6 

Zheng TZ, Boyle P, Hu HF, Duan J, Jiang PJ, Ma DQ, Shui LP, Niu SR and MacMahon B: Tobacco smoking, alcohol consumption, and risk of oral cancer: a case-control study in Beijing, People’s Republic of China. Cancer Causes Control. 1:173–179. 1990.

7 

Choi S and Myers JN: Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy. J Dent Res. 87:14–32. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Bensaad K and Vousden KH: p53: new roles in metabolism. Trends Cell Biol. 17:286–291. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Lozano G and Zambetti GP: What have animal models taught us about the p53 pathway? J Pathol. 205:206–220. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Agarwal A, Rani M, Saha GK, Valarmathi TM, Bahadur S, Mohanti BK and Das SN: Disregulated expression of the Th2 cytokine gene in patients with intraoral squamous cell carcinoma. Immunol Invest. 32:17–30. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, Kryukov GV, Lawrence MS, Sougnez C, McKenna A, et al: The mutational landscape of head and neck squamous cell carcinoma. Science. 333:1157–1160. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Grandis JR and Tweardy DJ: Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res. 53:3579–3584. 1993.

13 

Rubin Grandis J, Melhem MF, Gooding WE, Day R, Holst VA, Wagener MM, Drenning SD and Tweardy DJ: Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst. 90:824–832. 1998.

14 

Grandis JR and Tweardy DJ: TGF-alpha and EGFR in head and neck cancer. J Cell Biochem Suppl. 17F:188–191. 1993. View Article : Google Scholar : PubMed/NCBI

15 

Herbst RS, Giaccone G, Schiller JH, Natale RB, Miller V, Manegold C, Scagliotti G, Rosell R, Oliff I, Reeves JA, et al: Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 2. J Clin Oncol. 22:785–794. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Citri A and Yarden Y: EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol. 7:505–516. 2006. View Article : Google Scholar

17 

Kalyankrishna S and Grandis JR: Epidermal growth factor receptor biology in head and neck cancer. J Clin Oncol. 24:2666–2672. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Ciardiello F and Tortora G: EGFR antagonists in cancer treatment. N Engl J Med. 358:1160–1174. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Saba NF, Shin DM and Khuri FR: Targeting angiogenesis in head and neck cancer. Curr Cancer Drug Targets. 7:643–649. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Wheeler DL, Huang S, Kruser TJ, Nechrebecki MM, Armstrong EA, Benavente S, Gondi V, Hsu KT and Harari PM: Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members. Oncogene. 27:3944–3956. 2008. View Article : Google Scholar

21 

Quintana E, Shackleton M, Sabel MS, Fullen DR, Johnson TM and Morrison SJ: Efficient tumour formation by single human melanoma cells. Nature. 456:593–598. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Civenni G, Walter A, Kobert N, Mihic-Probst D, Zipser M, Belloni B, Seifert B, Moch H, Dummer R, van den Broek M and Sommer L: Human CD271-positive melanoma stem cells associated with metastasis establish tumor heterogeneity and long-term growth. Cancer Res. 71:3098–3109. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Prince ME, Sivanandan R, Kaczorowski A, Wolf GT, Kaplan MJ, Dalerba P, Weissman IL, Clarke MF and Ailles LE: Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci USA. 104:973–978. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Krishnamurthy S, Dong Z, Vodopyanov D, et al: Endothelial cell-initiated signaling promotes the survival and self-renewal of cancer stem cells. Cancer Res. 70:9969–9978. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Whiteside TL: Immunobiology and immunotherapy of head and neck cancer. Curr Oncol Rep. 3:46–55. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Almand B, Resser JR, Lindman B, Nadaf S, Clark JI, Kwon ED, Carbone DP and Gabrilovich DI: Clinical significance of defective dendritic cell differentiation in cancer. Clin Cancer Res. 6:1755–1766. 2000.PubMed/NCBI

27 

Duray A, Demoulin S, Hubert P, Delvenne P and Saussez S: Immune suppression in head and neck cancers: a review. Clin Dev Immunol. 2010:7016572010. View Article : Google Scholar : PubMed/NCBI

28 

Saito T, Kuss I, Dworacki G, Gooding W, Johnson JT and Whiteside TL: Spontaneous ex vivo apoptosis of peripheral blood mononuclear cells in patients with head and neck cancer. Clin Cancer Res. 5:1263–1273. 1999.PubMed/NCBI

29 

Zamarron BF and Chen W: Dual roles of immune cells and their factors in cancer development and progression. Int J Biol Sci. 7:651–658. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Kuss I, Donnenberg AD, Gooding W and Whiteside TL: Effector CD8+CD45RO−CD27−T cells have signalling defects in patients with squamous cell carcinoma of the head and neck. Br J Cancer. 88:223–230. 2003.

31 

Kuss I, Hathaway B, Ferris RL, Gooding W and Whiteside TL: Decreased absolute counts of T lymphocyte subsets and their relation to disease in squamous cell carcinoma of the head and neck. Clin Cancer Res. 10:3755–3762. 2004. View Article : Google Scholar

32 

Campoli M, Chang CC and Ferrone S: HLA class I antigen loss, tumor immune escape and immune selection. Vaccine. 20(Suppl 4): A40–A45. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Vora AR, Rodgers S, Parker AJ, Start R, Rees RC and Murray AK: An immunohistochemical study of altered immunomodulatory molecule expression in head and neck squamous cell carcinoma. Br J Cancer. 76:836–844. 1997. View Article : Google Scholar : PubMed/NCBI

34 

Kulkarni DP, Wadia PP, Pradhan TN, Pathak AK and Chiplunkar SV: Mechanisms involved in the down-regulation of TCR zeta chain in tumor versus peripheral blood of oral cancer patients. Int J Cancer. 124:1605–1613. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Valitutti S, Müller S, Salio M and Lanzavecchia A: Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation. J Exp Med. 185:1859–1864. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Sparano A, Lathers DM, Achille N, Petruzzelli GJ and Young MR: Modulation of Th1 and Th2 cytokine profiles and their association with advanced head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg. 131:573–576. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Whiteside TL: Anti-tumor vaccines in head and neck cancer: targeting immune responses to the tumor. Curr Cancer Drug Targets. 7:633–642. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Jebreel A, Mistry D, Loke D, Dunn G, Hough V, Oliver K, Stafford N and Greenman J: Investigation of interleukin 10, 12 and 18 levels in patients with head and neck cancer. J Laryngol Otol. 121:246–252. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Shevach EM: Regulatory/suppressor T cells in health and disease. Arthritis Rheum. 50:2721–2724. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Cesana GC, DeRaffele G, Cohen S, Moroziewicz D, Mitcham J, Stoutenburg J, Cheung K, Hesdorffer C, Kim-Schulze S and Kaufman HL: Characterization of CD4+CD25+ regulatory T cells in patients treated with high-dose interleukin-2 for metastatic melanoma or renal cell carcinoma. J Clin Oncol. 24:1169–1177. 2006.PubMed/NCBI

41 

Mizukami Y, Kono K, Kawaguchi Y, Akaike H, Kamimura K, Sugai H and Fujii H: Localisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer. Br J Cancer. 98:148–153. 2008.PubMed/NCBI

42 

Strauss L, Bergmann C and Whiteside TL: Functional and phenotypic characteristics of CD4+CD25highFoxp3+ Treg clones obtained from peripheral blood of patients with cancer. Int J Cancer. 121:2473–2483. 2007.PubMed/NCBI

43 

André F, Chaput N, Schartz NE, Flament C, Aubert N, Bernard J, Lemonnier F, Raposo G, Escudier B, Hsu DH, et al: Exosomes as potent cell-free peptide-based vaccine. I Dendritic cell-derived exosomes transfer functional MHC class I/peptide complexes to dendritic cells. J Immunol. 172:2126–2136. 2004.PubMed/NCBI

44 

Mende I and Engleman EG: Breaking tolerance to tumors with dendritic cell-based immunotherapy. Ann NY Acad Sci. 1058:96–104. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Steinman RM: Dendritic cells: understanding immunogenicity. Eur J Immunol. 37(Suppl 1): S53–S60. 2007. View Article : Google Scholar

46 

Todryk S: A sense of tumour for the immune system. Immunology. 107:1–4. 2002. View Article : Google Scholar : PubMed/NCBI

47 

Cools N, Ponsaerts P, Van Tendeloo VF and Berneman ZN: Balancing between immunity and tolerance: an interplay between dendritic cells, regulatory T cells, and effector T cells. J Leukoc Biol. 82:1365–1374. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Almand B, Clark JI, Nikitina E, van Beynen J, English NR, Knight SC, Carbone DP and Gabrilovich DI: Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. J Immunol. 166:678–689. 2001. View Article : Google Scholar : PubMed/NCBI

49 

Tas MP, Simons PJ, Balm FJ and Drexhage HA: Depressed monocyte polarization and clustering of dendritic cells in patients with head and neck cancer: in vitro restoration of this immunosuppression by thymic hormones. Cancer Immunol Immunother. 36:108–114. 1993. View Article : Google Scholar

50 

Gabrilovich DI, Chen HL, Girgis KR, et al: Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat Med. 2:1096–1103. 1996. View Article : Google Scholar : PubMed/NCBI

51 

Allavena P, Piemonti L, Longoni D, Bernasconi S, Stoppacciaro A, Ruco L and Mantovani A: IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages. Eur J Immunol. 28:359–369. 1998. View Article : Google Scholar

52 

Péguet-Navarro J, Moulon C, Caux C, Dalbiez-Gauthier C, Banchereau J and Schmitt D: Interleukin-10 inhibits the primary allogeneic T cell response to human epidermal Langerhans cells. Eur J Immunol. 24:884–891. 1994.PubMed/NCBI

53 

Steinbrink K, Wölfl M, Jonuleit H, Knop J and Enk AH: Induction of tolerance by IL-10-treated dendritic cells. J Immunol. 159:4772–4780. 1997.PubMed/NCBI

54 

Cerwenka A and Lanier LL: Natural killer cells, viruses and cancer. Nat Rev Immunol. 1:41–49. 2001. View Article : Google Scholar : PubMed/NCBI

55 

Yokoyama WM, Kim S and French AR: The dynamic life of natural killer cells. Annu Rev Immunol. 22:405–429. 2004. View Article : Google Scholar : PubMed/NCBI

56 

Lee SC, Srivastava RM, López-Albaitero A, Ferrone S and Ferris RL: Natural killer (NK): dendritic cell (DC) cross talk induced by therapeutic monoclonal antibody triggers tumor antigen-specific T cell immunity. Immunol Res. 50:248–254. 2011. View Article : Google Scholar : PubMed/NCBI

57 

González FM, Vargas JA, López-Cortijo C, Castejón R, Gorriz C, Ramírez-Camacho R, Millán I and Durántez A: Prognostic significance of natural killer cell activity in patients with laryngeal carcinoma. Arch Otolaryngol Head Neck Surg. 124:852–856. 1998.

58 

Thomas L: On immunosurveillance in human cancer. Yale J Biol Med. 55:329–33. 1982.PubMed/NCBI

59 

Schreiber RD, Old LJ and Smyth MJ: Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science. 331:1565–1570. 2011.PubMed/NCBI

60 

Dunn GP, Bruce AT, Ikeda H, Old LJ and Schreiber RD: Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol. 3:991–998. 2002. View Article : Google Scholar : PubMed/NCBI

61 

Vattemi E and Claudio PP: The feasibility of gene therapy in the treatment of head and neck cancer. Head Neck Oncol. 1:32009. View Article : Google Scholar : PubMed/NCBI

62 

Morgan RA, Dudley ME, Wunderlich JR, Hughes MS, Yang JC, Sherry RM, Royal RE, Topalian SL, Kammula US, Restifo NP, et al: Cancer regression in patients after transfer of genetically engineered lymphocytes. Science. 314:126–129. 2006. View Article : Google Scholar : PubMed/NCBI

63 

Abuzeid WM, Li D and O’Malley BW Jr: Gene therapy for head and neck cancer. Adv Otorhinolaryngol. 70:141–151. 2011.PubMed/NCBI

64 

De Costa AM and Young MR: Immunotherapy for head and neck cancer: advances and deficiencies. Anticancer Drugs. 22:674–681. 2011.PubMed/NCBI

65 

Harrington KJ, Nutting CM and Pandha HS: Gene therapy for head and neck cancer. Cancer Metastasis Rev. 24:147–164. 2005. View Article : Google Scholar : PubMed/NCBI

66 

O’Malley BW, Cope KA, Chen SH, Li D, Schwarta MR and Woo SL: Combination gene therapy for oral cancer in a murine model. Cancer Res. 56:1737–1741. 1996.PubMed/NCBI

67 

Case SS, Price MA, Jordan CT, Yu XJ, Wang L, Bauer G, Haas DL, Xu D, Stripecke R, Naldini L, et al: Stable transduction of quiescent CD34(+)CD38(−) human hematopoietic cells by HIV-1-based lentiviral vectors. Proc Natl Acad Sci USA. 96:2988–2993. 1999.

68 

Chang LJ and Gay EE: The molecular genetics of lentiviral vectors - current and future perspectives. Curr Gene Ther. 1:237–251. 2001. View Article : Google Scholar : PubMed/NCBI

69 

Roe T, Reynolds TC, Yu G and Brown PO: Integration of murine leukemia virus DNA depends on mitosis. EMBO J. 12:2099–2108. 1993.PubMed/NCBI

70 

Schroers R, Sinha I, Segall H, et al: Transduction of human PBMC-derived dendritic cells and macrophages by an HIV-1-based lentiviral vector system. Mol Ther. 1:171–179. 2000. View Article : Google Scholar : PubMed/NCBI

71 

Kung SK, An DS, Bonifacino A, Metzger ME, Ringpis GE, Mao SH, Chen IS and Donahue RE: Induction of transgene-specific immunological tolerance in myeloablated nonhuman primates using lentivirally transduced CD34+ progenitor cells. Mol Ther. 8:981–991. 2003. View Article : Google Scholar

72 

Montini E, Cesana D, Schmidt M, Sanvito F, Ponzoni M, Bartholomae C, Sergi Sergi L, Benedicenti F, Ambrosi A, Di Serio C, et al: Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration. Nat Biotechnol. 24:687–696. 2006. View Article : Google Scholar : PubMed/NCBI

73 

Mahmood S, Kanwar N, Tran J, Zhang ML and Kung SK: SHP-1 phosphatase is a critical regulator in preventing natural killer cell self-killing. PLoS One. 7:e442442012. View Article : Google Scholar : PubMed/NCBI

74 

Tran J, Mahmood S, Carlyle JR and Kung SK: Altering the specificity of NK:target cell interactions by genetic manipulation of NK receptor expression on primary mouse NK cells. Vaccine. 28:3767–3772. 2010. View Article : Google Scholar : PubMed/NCBI

75 

Hoffmann TK: Systemic therapy strategies for head-neck carcinomas: Current status. GMS Curr Top Otorhinolaryngol Head Neck Surg. 11:Doc032012.(In German).

76 

Steeg PS: Metastasis suppressors alter the signal transduction of cancer cells. Nat Rev Cancer. 3:55–63. 2003. View Article : Google Scholar : PubMed/NCBI

77 

Egeblad M and Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer. 2:161–174. 2002. View Article : Google Scholar : PubMed/NCBI

78 

Folgueras AR, Pendás AM, Sánchez LM and López-Otín C: Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies. Int J Dev Biol. 48:411–424. 2004. View Article : Google Scholar : PubMed/NCBI

79 

Noel A, Maillard C, Rocks N, Jost M, Chabottaux V, Sounni NE, Maquoi E, Cataldo D and Foidart JM: Membrane associated proteases and their inhibitors in tumour angiogenesis. J Clin Pathol. 57:577–584. 2004. View Article : Google Scholar : PubMed/NCBI

80 

Overall CM and López-Otín C: Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer. 2:657–672. 2002. View Article : Google Scholar : PubMed/NCBI

81 

Liotta LA, Tryggvason K, Garbisa S, Hart I, Foltz CM and Shafie S: Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature. 284:67–68. 1980. View Article : Google Scholar : PubMed/NCBI

82 

Sun Y, Liu M, Yang B, Li B and Lu J: Role of siRNA silencing of MMP-2 gene on invasion and growth of laryngeal squamous cell carcinoma. Eur Arch Otorhinolaryngol. 265:1385–1391. 2008. View Article : Google Scholar : PubMed/NCBI

83 

Xie SM, Fang WY, Liu Z, Wang SX, Li X, Liu TF, Xie WB and Yao KT: Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin. J Transl Med. 6:552008. View Article : Google Scholar

84 

Siddik ZH: Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene. 22:7265–7279. 2003. View Article : Google Scholar : PubMed/NCBI

85 

Dean M, Hamon Y and Chimini G: The human ATP-binding cassette (ABC) transporter superfamily. J Lipid Res. 42:1007–1017. 2001.PubMed/NCBI

86 

Taniguchi K, Wada M, Kohno K, Nakamura T, Kawabe T, Kawakami M, Kagotani K, Okumura K, Akiyama S and Kuwano M: A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res. 56:4124–4129. 1996.

87 

Balkwill F: The significance of cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol. 14:171–179. 2004. View Article : Google Scholar : PubMed/NCBI

88 

Kang H, Watkins G, Douglas-Jones A, Mansel RE and Jiang WG: The elevated level of CXCR4 is correlated with nodal metastasis of human breast cancer. Breast. 14:360–367. 2005. View Article : Google Scholar : PubMed/NCBI

89 

Sokolowska-Wojdylo M, Wenzel J, Gaffal E, Lenz J, Speuser P, Erdmann S, Abuzahra F, Bowman E, Roszkiewicz J, Bieber T and Tüting T: Circulating clonal CLA(+) and CD4(+) T cells in Sezary syndrome express the skin-homing chemokine receptors CCR4 and CCR10 as well as the lymph node-homing chemokine receptor CCR7. Br J Dermatol. 152:258–264. 2005.

90 

Hong JS, Pai HK, Hong KO, Kim MA, Kim JH, Lee JI, Hong SP and Hong SD: CXCR-4 knockdown by small interfering RNA inhibits cell proliferation and invasion of oral squamous cell carcinoma cells. J Oral Pathol Med. 38:214–219. 2009. View Article : Google Scholar : PubMed/NCBI

91 

Chen YC, Chen YW, Hsu HS, Tseng LM, Huang PI, Lu KH, Chen DT, Tai LK, Yung MC, Chang SC, et al: Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer. Biochem Biophys Res Commun. 385:307–313. 2009. View Article : Google Scholar : PubMed/NCBI

92 

Chen YC, Chang CJ, Hsu HS, Chen YW, Tai LK, Tseng LM, Chiou GY, Chang SC, Kao SY, Chiou SH and Lo WL: Inhibition of tumorigenicity and enhancement of radiochemosensitivity in head and neck squamous cell cancer-derived ALDH1-positive cells by knockdown of Bmi-1. Oral Oncol. 46:158–165. 2010. View Article : Google Scholar : PubMed/NCBI

93 

Badoual C, Sandoval F, Pere H, Hans S, Gey A, Merillon N, Van Ryswick C, Quintin-Colonna F, Bruneval P, Brasnu D, et al: Better understanding tumor-host interaction in head and neck cancer to improve the design and development of immunotherapeutic strategies. Head Neck. 32:946–958. 2010.

94 

Young MR: Protective mechanisms of head and neck squamous cell carcinomas from immune assault. Head Neck. 28:462–470. 2006. View Article : Google Scholar : PubMed/NCBI

95 

Hathaway B, Landsittel DP, Gooding W, Whiteside TL, Grandis JR, Siegfried JM, Bigbee WL and Ferris RL: Multiplexed analysis of serum cytokines as biomarkers in squamous cell carcinoma of the head and neck patients. Laryngoscope. 115:522–527. 2005. View Article : Google Scholar

96 

Reichert TE, Rabinowich H, Johnson JT and Whiteside TL: Mechanisms responsible for signaling and functional defects. J Immunother. 21:295–306. 1998. View Article : Google Scholar : PubMed/NCBI

97 

Planelles V and Benichou S: Vpr and its interactions with cellular proteins. Curr Top Microbiol Immunol. 339:177–200. 2009.PubMed/NCBI

98 

Poon B, Jowett JB, Stewart SA, Armstrong RW, Rishton GM and Chen IS: Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard. J Virol. 71:3961–3971. 1997.

99 

Stewart SA, Poon B, Song JY and Chen IS: Human immunodeficiency virus type 1 vpr induces apoptosis through caspase activation. J Virol. 74:3105–3111. 2000. View Article : Google Scholar : PubMed/NCBI

100 

Pang S, Kang MK, Kung S, et al: Anticancer effect of a lentiviral vector capable of expressing HIV-1 Vpr. Clin Cancer Res. 7:3567–3573. 2001.PubMed/NCBI

101 

Dai B, Yang L, Yang H, Hu B, Baltimore D and Wang P: HIV-1 Gag-specific immunity induced by a lentivector-based vaccine directed to dendritic cells. Proc Natl Acad Sci USA. 106:20382–20387. 2009. View Article : Google Scholar

102 

Morizono K, Xie Y, Ringpis GE, Johnson M, Nassanian H, Lee B, Wu L and Chen IS: Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection. Nat Med. 11:346–352. 2005. View Article : Google Scholar : PubMed/NCBI

103 

Morizono K, Xie Y, Helguera G, Daniels TR, Lane TF, Penichet ML and Chen IS: A versatile targeting system with lentiviral vectors bearing the biotin-adaptor peptide. J Gene Med. 11:655–663. 2009. View Article : Google Scholar : PubMed/NCBI

104 

Morizono K, Pariente N, Xie Y and Chen IS: Redirecting lentiviral vectors by insertion of integrin-tageting peptides into envelope proteins. J Gene Med. 11:549–558. 2009. View Article : Google Scholar : PubMed/NCBI

105 

Saenz DT, Loewen N, Peretz M, Whitwam T, Barraza R, Howell KG, Holmes JM, Good M and Poeschla EM: Unintegrated lentivirus DNA persistence and accessibility to expression in nondividing cells: analysis with class I integrase mutants. J Virol. 78:2906–2920. 2004. View Article : Google Scholar : PubMed/NCBI

106 

Apolonia L, Waddington SN, Fernandes C, Ward NJ, Bouma G, Blundell MP, Thrasher AJ, Collins MK and Philpott NJ: Stable gene transfer to muscle using non-integrating lentiviral vectors. Mol Ther. 15:1947–1954. 2007. View Article : Google Scholar : PubMed/NCBI

107 

Negri DR, Michelini Z, Baroncelli S, Spada M, Vendetti S, Buffa V, Bona R, Leone P, Klotman ME and Cara A: Successful immunization with a single injection of non-integrating lentiviral vector. Mol Ther. 15:1716–1723. 2007. View Article : Google Scholar : PubMed/NCBI

108 

Rahim AA, Wong AM, Howe SJ, Buckley SM, Acosta-Saltos AD, Elston KE, Ward NJ, Philpott NJ, Cooper JD, Anderson PN, et al: Efficient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors. Gene Ther. 16:509–520. 2009. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Upreti D, Pathak A and Kung SK: Lentiviral vector‑based therapy in head and neck cancer (Review). Oncol Lett 7: 3-9, 2014.
APA
Upreti, D., Pathak, A., & Kung, S.K. (2014). Lentiviral vector‑based therapy in head and neck cancer (Review). Oncology Letters, 7, 3-9. https://doi.org/10.3892/ol.2013.1652
MLA
Upreti, D., Pathak, A., Kung, S. K."Lentiviral vector‑based therapy in head and neck cancer (Review)". Oncology Letters 7.1 (2014): 3-9.
Chicago
Upreti, D., Pathak, A., Kung, S. K."Lentiviral vector‑based therapy in head and neck cancer (Review)". Oncology Letters 7, no. 1 (2014): 3-9. https://doi.org/10.3892/ol.2013.1652
Copy and paste a formatted citation
x
Spandidos Publications style
Upreti D, Pathak A and Kung SK: Lentiviral vector‑based therapy in head and neck cancer (Review). Oncol Lett 7: 3-9, 2014.
APA
Upreti, D., Pathak, A., & Kung, S.K. (2014). Lentiviral vector‑based therapy in head and neck cancer (Review). Oncology Letters, 7, 3-9. https://doi.org/10.3892/ol.2013.1652
MLA
Upreti, D., Pathak, A., Kung, S. K."Lentiviral vector‑based therapy in head and neck cancer (Review)". Oncology Letters 7.1 (2014): 3-9.
Chicago
Upreti, D., Pathak, A., Kung, S. K."Lentiviral vector‑based therapy in head and neck cancer (Review)". Oncology Letters 7, no. 1 (2014): 3-9. https://doi.org/10.3892/ol.2013.1652
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