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Article

Low dose of interferon‑α improves the clinical outcomes of docetaxel in patients with castration‑resistant prostate cancer: A pilot study

  • Authors:
    • Yun‑Fei Li
    • Qin‑Zhang Wang
    • Tao‑Tao Zhang
    • Lei Li
    • Jiang‑Ping Wang
    • Guo‑Fu Ding
    • Da‑Lin He
  • View Affiliations / Copyright

    Affiliations: Department of Urology, First Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China , Department of Urology, First Hospital of Shihezi University, Shihezi, Xinjiang 832008, P.R. China
  • Pages: 125-130
    |
    Published online on: November 1, 2013
       https://doi.org/10.3892/ol.2013.1653
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Abstract

The aim of this study was to test whether a low dose of interferon‑α‑2b (IFN‑α2b) enhances the clinical outcome of docetaxel (DXT) in patients with castration‑resistant prostate cancer (CRPC). A prospective controlled trial of 40 CRPC patients receiving 5 mg of prednisone twice daily was conducted, where patients were randomly assigned to be administered 75 mg/m2 DXT plus 3 mIU/m2 IFN‑α2b (group A, n=20) or 75 mg/m2 DXT alone (group B, n=20). The prostate‑specific antigen (PSA) response, tumor response, progression‑free survival (PFS) and overall survival (OS) were evaluated. There was no statistically significant difference in PSA response rate between groups A and B (65 vs. 47.4%, P=0.341). The tumor response rate in group A was significantly greater compared with that in group B (55 vs. 21.1%, P=0.048). The median PFS was longer in group A compared with that in group B (10 vs. 8 months, P=0.043). There was no statistically significant difference in median OS between the two groups (19 vs. 17 months, P=0.348), but one patient displayed a complete tumor response in group A. In groups A and B, transient grade 3 to 4 neutropenia was observed in nine and six patients, grade 3 to 4 anemia was observed in three and five patients, and grade 3 to 4 general fatigue was observed in four and one patient(s), respectively. The proportion of patients with grade 3 to 4 toxicity was not statistically different between the two groups. A low dosage of IFN‑α2b may improve the antitumor activity of DXT with an acceptable toxicity profile in patients with CRPC.
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Copy and paste a formatted citation
Spandidos Publications style
Li YF, Wang QZ, Zhang TT, Li L, Wang JP, Ding GF and He DL: Low dose of interferon‑α improves the clinical outcomes of docetaxel in patients with castration‑resistant prostate cancer: A pilot study. Oncol Lett 7: 125-130, 2014.
APA
Li, Y., Wang, Q., Zhang, T., Li, L., Wang, J., Ding, G., & He, D. (2014). Low dose of interferon‑α improves the clinical outcomes of docetaxel in patients with castration‑resistant prostate cancer: A pilot study. Oncology Letters, 7, 125-130. https://doi.org/10.3892/ol.2013.1653
MLA
Li, Y., Wang, Q., Zhang, T., Li, L., Wang, J., Ding, G., He, D."Low dose of interferon‑α improves the clinical outcomes of docetaxel in patients with castration‑resistant prostate cancer: A pilot study". Oncology Letters 7.1 (2014): 125-130.
Chicago
Li, Y., Wang, Q., Zhang, T., Li, L., Wang, J., Ding, G., He, D."Low dose of interferon‑α improves the clinical outcomes of docetaxel in patients with castration‑resistant prostate cancer: A pilot study". Oncology Letters 7, no. 1 (2014): 125-130. https://doi.org/10.3892/ol.2013.1653
Copy and paste a formatted citation
x
Spandidos Publications style
Li YF, Wang QZ, Zhang TT, Li L, Wang JP, Ding GF and He DL: Low dose of interferon‑α improves the clinical outcomes of docetaxel in patients with castration‑resistant prostate cancer: A pilot study. Oncol Lett 7: 125-130, 2014.
APA
Li, Y., Wang, Q., Zhang, T., Li, L., Wang, J., Ding, G., & He, D. (2014). Low dose of interferon‑α improves the clinical outcomes of docetaxel in patients with castration‑resistant prostate cancer: A pilot study. Oncology Letters, 7, 125-130. https://doi.org/10.3892/ol.2013.1653
MLA
Li, Y., Wang, Q., Zhang, T., Li, L., Wang, J., Ding, G., He, D."Low dose of interferon‑α improves the clinical outcomes of docetaxel in patients with castration‑resistant prostate cancer: A pilot study". Oncology Letters 7.1 (2014): 125-130.
Chicago
Li, Y., Wang, Q., Zhang, T., Li, L., Wang, J., Ding, G., He, D."Low dose of interferon‑α improves the clinical outcomes of docetaxel in patients with castration‑resistant prostate cancer: A pilot study". Oncology Letters 7, no. 1 (2014): 125-130. https://doi.org/10.3892/ol.2013.1653
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