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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Article

Inhibition of Annexin A2 gene transcription is a promising molecular target for hepatoma cell proliferation and metastasis

  • Authors:
    • Zhizhen Dong
    • Min Yao
    • Haijian Zhang
    • Li Wang
    • Hua Huang
    • Meijuan Yan
    • Wei Wu
    • Dengfu Yao
  • View Affiliations / Copyright

    Affiliations: Research Centre of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Medical School of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China
  • Pages: 28-34
    |
    Published online on: November 6, 2013
       https://doi.org/10.3892/ol.2013.1663
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Abstract

Hepatocyte Annexin A2 (ANXA2) expression is associated with the progression and metastasis of hepatocellular carcinoma (HCC). Circulating ANXA2 levels in HCC patients are significantly higher compared with that of patients with benign liver disease. ANXA2 levels have been found to correlate with hepatitis B virus infection, extrahepatic metastasis and portal vein thrombus. By contrast, ANXA2 levels do not correlate with tumour size and AFP levels. However, the underlying mechanisms of ANXA2 remain obscure. The results of the current study identified that abnormalities in hepatic ANXA2 expression were localised to the cell membrane and cytoplasm of HCC tissues and mainly in the cytoplasm of para‑cancerous tissues. ANXA2 was overexpressed in MHCC97‑H cells which have high metastatic potential. Following specific ANXA2‑small hairpin RNA (shRNA) transfection in vitro, ANXA‑2 was effectively inhibited and the S phase ratio of cells was 27.76%, compared with 36.14% in mock‑treated cells. In addition, the invading cell ratio was reduced in the shRNA‑treated group (52.16%) compared with the mock‑treated group (86.14%). The growth and volume of xenograft tumours in vivo was significantly suppressed (P<0.05) in the shRNA group compared with that of the mock group, indicating that ANXA2 may be a novel and useful target for elucidating molecular mechanisms involving the proliferation and metastasis of HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Dong Z, Yao M, Zhang H, Wang L, Huang H, Yan M, Wu W and Yao D: Inhibition of Annexin A2 gene transcription is a promising molecular target for hepatoma cell proliferation and metastasis. Oncol Lett 7: 28-34, 2014.
APA
Dong, Z., Yao, M., Zhang, H., Wang, L., Huang, H., Yan, M. ... Yao, D. (2014). Inhibition of Annexin A2 gene transcription is a promising molecular target for hepatoma cell proliferation and metastasis. Oncology Letters, 7, 28-34. https://doi.org/10.3892/ol.2013.1663
MLA
Dong, Z., Yao, M., Zhang, H., Wang, L., Huang, H., Yan, M., Wu, W., Yao, D."Inhibition of Annexin A2 gene transcription is a promising molecular target for hepatoma cell proliferation and metastasis". Oncology Letters 7.1 (2014): 28-34.
Chicago
Dong, Z., Yao, M., Zhang, H., Wang, L., Huang, H., Yan, M., Wu, W., Yao, D."Inhibition of Annexin A2 gene transcription is a promising molecular target for hepatoma cell proliferation and metastasis". Oncology Letters 7, no. 1 (2014): 28-34. https://doi.org/10.3892/ol.2013.1663
Copy and paste a formatted citation
x
Spandidos Publications style
Dong Z, Yao M, Zhang H, Wang L, Huang H, Yan M, Wu W and Yao D: Inhibition of Annexin A2 gene transcription is a promising molecular target for hepatoma cell proliferation and metastasis. Oncol Lett 7: 28-34, 2014.
APA
Dong, Z., Yao, M., Zhang, H., Wang, L., Huang, H., Yan, M. ... Yao, D. (2014). Inhibition of Annexin A2 gene transcription is a promising molecular target for hepatoma cell proliferation and metastasis. Oncology Letters, 7, 28-34. https://doi.org/10.3892/ol.2013.1663
MLA
Dong, Z., Yao, M., Zhang, H., Wang, L., Huang, H., Yan, M., Wu, W., Yao, D."Inhibition of Annexin A2 gene transcription is a promising molecular target for hepatoma cell proliferation and metastasis". Oncology Letters 7.1 (2014): 28-34.
Chicago
Dong, Z., Yao, M., Zhang, H., Wang, L., Huang, H., Yan, M., Wu, W., Yao, D."Inhibition of Annexin A2 gene transcription is a promising molecular target for hepatoma cell proliferation and metastasis". Oncology Letters 7, no. 1 (2014): 28-34. https://doi.org/10.3892/ol.2013.1663
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