Sustained complete response of hepatocellular carcinoma with portal vein tumor thrombus following discontinuation of sorafenib: A case report

  • Authors:
    • Kazue Shiozawa
    • Manabu Watanabe
    • Takashi Ikehara
    • Yasushi Matsukiyo
    • Michio Kogame
    • Masahiro Kanayama
    • Teppei Matsui
    • Yoshinori Kikuchi
    • Koji Ishii
    • Yoshinori Igarashi
    • Yasukiyo Sumino
  • View Affiliations

  • Published online on: November 7, 2013     https://doi.org/10.3892/ol.2013.1664
  • Pages: 50-52
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Abstract

Hepatocellular carcinoma (HCC) is the third most common cause of cancer‑associated mortality worldwide. No effective treatment has been established for unresectable advanced HCC, and the prognosis is poor. Sorafenib is an oral multi‑targeted tyrosine kinase inhibitor for unresectable advanced HCC that significantly improves progression‑free and overall survival. However, in the two large phase III clinical trials (the SHARP and Asia‑Pacific trials), no cases of complete response (CR) were reported. The present study reports the case of a 68‑year‑old male with hepatitis C virus‑related cirrhosis and multiple recurrent HCCs, with a tumor thrombus of the third portal vein following resection. The patient received 400 mg once daily (half the standard dose) of sorafenib for two years and achieved a CR. At the most recent follow‑up examination at one year after the cessation of treatment, the patient was observed to be in remission without clinical or imaging evidence of disease recurrence.
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December 2013
Volume 7 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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APA
Shiozawa, K., Watanabe, M., Ikehara, T., Matsukiyo, Y., Kogame, M., Kanayama, M. ... Sumino, Y. (2013). Sustained complete response of hepatocellular carcinoma with portal vein tumor thrombus following discontinuation of sorafenib: A case report. Oncology Letters, 7, 50-52. https://doi.org/10.3892/ol.2013.1664
MLA
Shiozawa, K., Watanabe, M., Ikehara, T., Matsukiyo, Y., Kogame, M., Kanayama, M., Matsui, T., Kikuchi, Y., Ishii, K., Igarashi, Y., Sumino, Y."Sustained complete response of hepatocellular carcinoma with portal vein tumor thrombus following discontinuation of sorafenib: A case report". Oncology Letters 7.1 (2013): 50-52.
Chicago
Shiozawa, K., Watanabe, M., Ikehara, T., Matsukiyo, Y., Kogame, M., Kanayama, M., Matsui, T., Kikuchi, Y., Ishii, K., Igarashi, Y., Sumino, Y."Sustained complete response of hepatocellular carcinoma with portal vein tumor thrombus following discontinuation of sorafenib: A case report". Oncology Letters 7, no. 1 (2013): 50-52. https://doi.org/10.3892/ol.2013.1664