Signet‑ring cell melanoma with sentinel lymph node metastasis: A case report with immunohistochemical analysis and review of the clinicopathological features

Ishida,Mitsuaki; Iwai,Muneo; Yoshida,Keiko; Kagotani,Akiko; Okabe,Hidetoshi

doi:10.3892/ol.2013.1669

2014-January Volume 7 Issue 1

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2014-January Volume 7 Issue 1

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Case Report

Signet‑ring cell melanoma with sentinel lymph node metastasis: A case report with immunohistochemical analysis and review of the clinicopathological features

Authors:
- Mitsuaki Ishida
- Muneo Iwai
- Keiko Yoshida
- Akiko Kagotani
- Hidetoshi Okabe
View Affiliations / Copyright

Affiliations: Department of Clinical Laboratory Medicine and Division of Diagnostic Pathology, Shiga University of Medical Science, Otsu, Shiga 520‑2192, Japan
Pages: 65-68
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Published online on: November 7, 2013

https://doi.org/10.3892/ol.2013.1669
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Abstract

Signet‑ring cell melanoma is an extremely rare variant of malignant melanoma. A 68‑year‑old male presented with a black nodule on the left thigh. Histopathological examination revealed proliferation of sheet‑like or variable‑sized nests of atypical melanocytes. Neoplastic cells showing signet‑ring cell appearance, characterized by the presence of eccentrically located enlarged nuclei and abundant pale cytoplasm, were also present. Immunohistochemically, the tumor cells were positive for S‑100 protein, vimentin and Melan‑A. Moreover, mammalian target of rapamycin (mTOR) pathway proteins were diffusely expressed. The current case report presents the 21st reported case of signet‑ring cell melanoma. Analyses of the clinicopathological features revealed that this disease commonly affects middle‑aged males and the presence of metastatic signet‑ring cell melanoma with an unknown primary tumor. Immunohistochemical analyses of melanocytic markers have been useful for establishing the diagnosis of this type of disease, however, HMB‑45 is occasionally found to be negative. In addition, the present case report is the first to analyze the expression of mTOR pathway proteins, which are central proteins involved in carcinogenesis and its inhibitor has been proposed as a therapeutic target for various types of tumor. Therefore, the mTOR inhibitor may also be a potential candidate for the treatment of this type of tumor.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Signet‑ring cell melanoma with sentinel lymph node metastasis: A case report with immunohistochemical analysis and review of the clinicopathological features

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