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Article

Middle ear squamous papilloma: A report of four cases analyzed by HPV and EBV in situ hybridization

  • Authors:
    • Han Zhou
    • Zhibin Chen
    • Weiming Zhang
    • Guangqian Xing
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Pathology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China
  • Pages: 41-46
    |
    Published online on: November 11, 2013
       https://doi.org/10.3892/ol.2013.1675
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Abstract

Squamous papilloma involving the middle ear as a primary lesion is an extremely rare occurrence. The aims of the present study were to investigate the presence of human papilloma virus (HPV) and Epstein‑Barr virus (EBV) infections in primary middle ear squamous papilloma and to describe the clinical and pathological features of the disease along with therapeutic strategies. A retrospective review was conducted of four patients with clinical and pathological diagnoses of middle ear squamous papilloma. In situ hybridization (ISH) for a wide range of HPV DNA subtypes and EBV‑encoded RNA was performed in the tissue samples obtained from these patients. Only two cases of primary squamous papilloma in the middle ear have been previously reported in the English literature. These papillomas developed in males of ~60‑years of age and otorrhea was the most frequent complaint. Premalignant changes were observed in two of the present cases and ISH of HPV and EBV was negative in all four cases. The results of the present study indicated that chronic inflammatory stimulation, not HPV and EBV infection, is involved in the occurrence of middle ear squamous papilloma and its malignant transformation. Radical surgery and long‑term postoperative follow‑up are recommended due to its malignant and recurrent potential. Further genetic investigations with additional new cases are required to clarify the pathogenesis of squamous papilloma involving the middle ear.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou H, Chen Z, Zhang W and Xing G: Middle ear squamous papilloma: A report of four cases analyzed by HPV and EBV in situ hybridization. Oncol Lett 7: 41-46, 2014.
APA
Zhou, H., Chen, Z., Zhang, W., & Xing, G. (2014). Middle ear squamous papilloma: A report of four cases analyzed by HPV and EBV in situ hybridization. Oncology Letters, 7, 41-46. https://doi.org/10.3892/ol.2013.1675
MLA
Zhou, H., Chen, Z., Zhang, W., Xing, G."Middle ear squamous papilloma: A report of four cases analyzed by HPV and EBV in situ hybridization". Oncology Letters 7.1 (2014): 41-46.
Chicago
Zhou, H., Chen, Z., Zhang, W., Xing, G."Middle ear squamous papilloma: A report of four cases analyzed by HPV and EBV in situ hybridization". Oncology Letters 7, no. 1 (2014): 41-46. https://doi.org/10.3892/ol.2013.1675
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou H, Chen Z, Zhang W and Xing G: Middle ear squamous papilloma: A report of four cases analyzed by HPV and EBV in situ hybridization. Oncol Lett 7: 41-46, 2014.
APA
Zhou, H., Chen, Z., Zhang, W., & Xing, G. (2014). Middle ear squamous papilloma: A report of four cases analyzed by HPV and EBV in situ hybridization. Oncology Letters, 7, 41-46. https://doi.org/10.3892/ol.2013.1675
MLA
Zhou, H., Chen, Z., Zhang, W., Xing, G."Middle ear squamous papilloma: A report of four cases analyzed by HPV and EBV in situ hybridization". Oncology Letters 7.1 (2014): 41-46.
Chicago
Zhou, H., Chen, Z., Zhang, W., Xing, G."Middle ear squamous papilloma: A report of four cases analyzed by HPV and EBV in situ hybridization". Oncology Letters 7, no. 1 (2014): 41-46. https://doi.org/10.3892/ol.2013.1675
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