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Article

Analysis of the anticancer activity of curcuminoids, thiotryptophan and 4‑phenoxyphenol derivatives

  • Authors:
    • Shireen Parsai
    • Rick Keck
    • Ewa Skrzypczak‑Jankun
    • Jerzy Jankun
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Urology Research Center, College of Medicine, University of Toledo, Toledo, OH 43614, USA
  • Pages: 17-22
    |
    Published online on: November 12, 2013
       https://doi.org/10.3892/ol.2013.1679
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Abstract

Curcumin, a non‑nutritive yellow pigment derived from the rhizome of Curcuma longa (turmeric), is considered to be an established nutraceutical with anticancer activity. Turmeric contains three principal components, curcumin, demethoxycurcumin and bisdemethoxycurcumin, of which curcumin is most abundant and potent. The concurrence of a high consumption of turmeric and a low incidence of prostate cancer in Asian countries may suggest a role for curcumin in chemoprevention. Curcumin has been identified to exhibit anti‑inflammatory, anti‑oxidative and anticarcinogenic properties. Since the compound does not exhibit side effects, curcumin has been designated for several clinical trials as a treatment for human cancers. The pro‑apototic, antioxidant and anti‑inflammatory characteristics of curcumin are implicated in its anticancer activity, yet the mechanism of action of curcumin remains unknown. To achieve an effective pharmacological outcome, curcumin must reach and sustain appropriate levels at the site of action. However, the main disadvantage of curcumin is its high metabolic instability and poor aqueous solubility that limits its systemic bioavailability. To overcome this difficulty, the present study tested the anticancer activity of new curcumin‑like compounds (E21cH and Q012095H). Also, the use of new medicaments requires an understanding of their pharmacokinetic profiles and targets. Thus, molecular modeling methods were used to identify the targets of curcumin and curcumin‑like compounds compared with other anticancer drugs (Q012138 and Q012169AT), which were used as the controls. The present study identified several enzymes that are targeted by curcumin, aldo‑keto reductase family 1 member B10 (AKR1B10), serine/threonine‑protein kinase, protein kinase C, matrix metalloproteinase (MMP), cyclooxygenase and epidermal growth factor receptor, which were tested as targets for these anticancer chemicals. All the examined small compounds demonstrated anticancer activity in the in vitro experiments and may impact cancer cells by acting on AKR1B10, MMP‑9 and their targets.
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Copy and paste a formatted citation
Spandidos Publications style
Parsai S, Keck R, Skrzypczak‑Jankun E and Jankun J: Analysis of the anticancer activity of curcuminoids, thiotryptophan and 4‑phenoxyphenol derivatives. Oncol Lett 7: 17-22, 2014.
APA
Parsai, S., Keck, R., Skrzypczak‑Jankun, E., & Jankun, J. (2014). Analysis of the anticancer activity of curcuminoids, thiotryptophan and 4‑phenoxyphenol derivatives. Oncology Letters, 7, 17-22. https://doi.org/10.3892/ol.2013.1679
MLA
Parsai, S., Keck, R., Skrzypczak‑Jankun, E., Jankun, J."Analysis of the anticancer activity of curcuminoids, thiotryptophan and 4‑phenoxyphenol derivatives". Oncology Letters 7.1 (2014): 17-22.
Chicago
Parsai, S., Keck, R., Skrzypczak‑Jankun, E., Jankun, J."Analysis of the anticancer activity of curcuminoids, thiotryptophan and 4‑phenoxyphenol derivatives". Oncology Letters 7, no. 1 (2014): 17-22. https://doi.org/10.3892/ol.2013.1679
Copy and paste a formatted citation
x
Spandidos Publications style
Parsai S, Keck R, Skrzypczak‑Jankun E and Jankun J: Analysis of the anticancer activity of curcuminoids, thiotryptophan and 4‑phenoxyphenol derivatives. Oncol Lett 7: 17-22, 2014.
APA
Parsai, S., Keck, R., Skrzypczak‑Jankun, E., & Jankun, J. (2014). Analysis of the anticancer activity of curcuminoids, thiotryptophan and 4‑phenoxyphenol derivatives. Oncology Letters, 7, 17-22. https://doi.org/10.3892/ol.2013.1679
MLA
Parsai, S., Keck, R., Skrzypczak‑Jankun, E., Jankun, J."Analysis of the anticancer activity of curcuminoids, thiotryptophan and 4‑phenoxyphenol derivatives". Oncology Letters 7.1 (2014): 17-22.
Chicago
Parsai, S., Keck, R., Skrzypczak‑Jankun, E., Jankun, J."Analysis of the anticancer activity of curcuminoids, thiotryptophan and 4‑phenoxyphenol derivatives". Oncology Letters 7, no. 1 (2014): 17-22. https://doi.org/10.3892/ol.2013.1679
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