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Article

Paxillin expression is closely linked to the pathogenesis, progression and prognosis of gastric carcinomas

  • Authors:
    • Li‑Jun Xiao
    • En-Hong Zhao
    • Shuang Zhao
    • Xin Zheng
    • Hua‑Chuan Zheng
    • Yasuo Takano
    • Hong-Ru Song
  • View Affiliations / Copyright

    Affiliations: Department of Immunology, Chengde Medical University, Chengde, Hebei 067000, P.R. China, Third Surgical Department, Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, P.R. China, Clinical Cancer Institute, Kanagawa Cancer Center, Yokohama, Kanagawa 250-0134, Japan
  • Pages: 189-194
    |
    Published online on: November 19, 2013
       https://doi.org/10.3892/ol.2013.1686
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Abstract

Paxillin encodes a focal adhesion‑associated protein and is involved in the progression and aggressive phenotypes of malignancies through its interactions with the actin cytoskeleton and key signal transduction oncogenes. The present study aimed to investigate the clinicopathological and prognostic significance of paxillin in gastric cancer. The expression of paxillin was evaluated using tissue microarrays of gastric adjacent non‑cancerous mucosa, adenoma and carcinoma specimens by immunohistochemistry. Paxillin expression was compared against clinicopathological parameters and the survival time of the patients. Paxillin was highly expressed in gastric adenoma compared with that in non‑neoplastic mucosa and carcinoma (P<0.05). Paxillin expression was lower in the younger carcinoma patients compared with that in the elder carcinoma patients (P<0.05). Paxillin expression was negatively correlated with tumor size, depth of invasion and lymph node metastasis, but not with patient gender, lymphatic or venous invasion, or TNM staging (P>0.05). Higher paxillin expression was observed in intestinal‑type compared with diffuse‑type carcinoma (P<0.05). Kaplan‑Meier analysis indicated a positive association between paxillin expression and cumulative survival rate in all, advanced and intestinal‑type carcinoma patients (P<0.05). Multivariate analysis using the Cox proportional hazards model indicated that patient age, depth of invasion, lymphatic invasion, lymph node metastasis, TNM staging and Lauren classification were independent prognostic factors for all gastric carcinomas (P<0.05). Aberrant paxillin expression may be involved in the growth, invasion, metastasis and differentiation of gastric carcinoma. Altered paxillin expression may, therefore, be employed as an indicator of pathobiological behaviors and prognosis of gastric carcinomas.
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1 

Rivera F, Vega-Villegas ME and López-Brea MF: Chemotherapy of advanced gastric cancer. Cancer Treat Rev. 33:315–324. 2007. View Article : Google Scholar

2 

Kelley JR and Duggan JM: Gastric cancer epidemiology and risk factors. J Clin Epidemiol. 56:1–9. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Turner CE, Glenney JR Jr and Burridge K: Paxillin: a new vinculin-binding protein present in focal adhesions. J Cell Biol. 111:1059–1068. 1990. View Article : Google Scholar : PubMed/NCBI

4 

Deakin NO and Turner CE: Paxillin comes of age. J Cell Sci. 121:2435–2444. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Schaller MD: Paxillin: a focal adhesion-associated adaptor protein. Oncogene. 20:6459–6472. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Brown MC and Turner CE: Paxillin: adapting to change. Physiol Rev. 84:1315–1339. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Sattler M, Pisick E, Morrison PT and Salgia R: Role of the cytoskeletal protein paxillin in oncogenesis. Crit Rev Oncog. 11:63–76. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Huang C, Jacobson K and Schaller MD: A role for JNK-paxillin signaling in cell migration. Cell Cycle. 3:4–6. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Tremblay L, Hauck W, Aprikian AG, Begin LR, Chapdelaine A and Chevalier S: Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p50CSK in human metastatic prostate carcinoma. Int J Cancer. 68:164–171. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Jagadeeswaran R, Surawska H, Krishnaswamy S, Janamanchi V, Mackinnon AC, Seiwert TY, Loganathan S, Kanteti R, Reichman T, Nallasura V, et al: Paxillin is a target for somatic mutations in lung cancer: implications for cell growth and invasion. Cancer Res. 68:132–142. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Li BZ, Lei W, Zhang CY, Zhou F, Li N, Shi SS, Feng XL, Chen ZL, Hang J, Qiu B, et al: Increased expression of paxillin is found in human oesophageal squamous cell carcinoma: a tissue microarray study. J Int Med Res. 36:273–278. 2008. View Article : Google Scholar

12 

Short SM, Yoder BJ, Tarr SM, Prescott NL, Laniauskas S, Coleman KA, Downs-Kelly E, Pettay JD, Choueiri TK, Crowe JP, et al: The expression of the cytoskeletal focal adhesion protein paxillin in breast cancer correlates with HER2 overexpression and may help predict response to chemotherapy: a retrospective immunohistochemical study. Breast J. 13:130–139. 2007. View Article : Google Scholar

13 

Mackinnon AC, Tretiakova M, Henderson L, Mehta RG, Yan BC, Joseph L, Krausz T, Husain AN, Reid ME and Salgia R: Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease. J Clin Pathol. 64:16–24. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Scibelli A, d’Angelo D, Pelagalli A, Tafuri S, Avallone L, Della Morte R and Staiano N: Expression levels of the focal adhesion-associated proteins paxillin and p130CAS in canine and feline mammary tumors. Vet Res. 34:193–202. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Sobin LH and Wittekind CH: TNM Classification of malignant tumors. 6th edn. New Jersey: John Wiley & Sons; Hoboken: 2002

16 

Zheng H, Takahashi H, Murai Y, Cui Z, Nomoto K, Miwa S, Tsuneyama K and Takano Y: Pathobiological characteristics of intestinal and diffuse-type gastric carcinoma in Japan: an immunostaining study on the tissue microarray. J Clin Pathol. 60:273–277. 2007. View Article : Google Scholar

17 

Zheng HC, Li XH, Hara T, Masuda S, Yang XH, Guan YF and Takano Y: Mixed-type gastric carcinomas exhibit more aggressive features and indicate the histogenesis of carcinomas. Virchows Arch. 452:525–534. 2008. View Article : Google Scholar

18 

Kumada T, Tsuneyama K, Hatta H, Ishizawa S and Takano Y: Improved 1-h rapid immunostaining method using intermittent microwave irradiation: practicability based on 5 years application in Toyama Medical and Pharmaceutical University Hospital. Mod Pathol. 17:1141–1149. 2004.

19 

Chen J and Gallo KA: MLK3 regulates paxillin phosphorylation in chemokine- mediated breast cancer cell migration and invasion to drive metastasis. Cancer Res. 72:4130–4140. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Zheng HC, Tsuneyama K, Takahashi H, Miwa S, Sugiyama T, Popivanova BK, Fujii C, Nomoto K, Mukaida N and Takano Y: Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression. J Cancer Res Clin Oncol. 134:481–488. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Cai HX, Yang LC, Song XH, Liu ZR, Chen YB and Dong GK: Expression of paxillin and FAK mRNA and the related clinical significance in esophageal carcinoma. Mol Med Rep. 5:469–472. 2012.PubMed/NCBI

22 

Shi J, Wang S, Zhao E, Shi L, Xu X and Fang M: Paxillin expression levels are correlated with clinical stage and metastasis in salivary adenoid cystic carcinoma. J Oral Pathol Med. 39:548–551. 2010.PubMed/NCBI

23 

Li HG, Xie DR, Shen XM, Li HH, Zeng H and Zeng YJ: Clinicopathological significance of expression of paxillin, syndecan-1 and EMMPRIN in hepatocellular carcinoma. World J Gastroenterol. 11:1445–1451. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Li D, Ding J, Wang X, Wang C and Wu T: Fibronectin promotes tyrosine phosphorylation of paxillin and cell invasiveness in the gastric cancer cell line AGS. Tumori. 95:769–779. 2009.PubMed/NCBI

25 

Jun Q, Zhiwei W, Lilin M, Jing K and Qichao N: Effects of paxillin on HCT-8 human colorectal cancer cells. Hepatogastroenterology. 58:1951–1955. 2011.PubMed/NCBI

26 

Zuo W and Li H: Relationship of the expression of CD44v6 and paxillin to the prognosis of non-small cell lung carcinoma. Sichuan Da Xue Xue Bao Yi Xue Ban. 34:484–485. 2003.(In Chinese).

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Copy and paste a formatted citation
Spandidos Publications style
Xiao LJ, Zhao E, Zhao S, Zheng X, Zheng HC, Takano Y and Song H: Paxillin expression is closely linked to the pathogenesis, progression and prognosis of gastric carcinomas. Oncol Lett 7: 189-194, 2014.
APA
Xiao, L., Zhao, E., Zhao, S., Zheng, X., Zheng, H., Takano, Y., & Song, H. (2014). Paxillin expression is closely linked to the pathogenesis, progression and prognosis of gastric carcinomas. Oncology Letters, 7, 189-194. https://doi.org/10.3892/ol.2013.1686
MLA
Xiao, L., Zhao, E., Zhao, S., Zheng, X., Zheng, H., Takano, Y., Song, H."Paxillin expression is closely linked to the pathogenesis, progression and prognosis of gastric carcinomas". Oncology Letters 7.1 (2014): 189-194.
Chicago
Xiao, L., Zhao, E., Zhao, S., Zheng, X., Zheng, H., Takano, Y., Song, H."Paxillin expression is closely linked to the pathogenesis, progression and prognosis of gastric carcinomas". Oncology Letters 7, no. 1 (2014): 189-194. https://doi.org/10.3892/ol.2013.1686
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao LJ, Zhao E, Zhao S, Zheng X, Zheng HC, Takano Y and Song H: Paxillin expression is closely linked to the pathogenesis, progression and prognosis of gastric carcinomas. Oncol Lett 7: 189-194, 2014.
APA
Xiao, L., Zhao, E., Zhao, S., Zheng, X., Zheng, H., Takano, Y., & Song, H. (2014). Paxillin expression is closely linked to the pathogenesis, progression and prognosis of gastric carcinomas. Oncology Letters, 7, 189-194. https://doi.org/10.3892/ol.2013.1686
MLA
Xiao, L., Zhao, E., Zhao, S., Zheng, X., Zheng, H., Takano, Y., Song, H."Paxillin expression is closely linked to the pathogenesis, progression and prognosis of gastric carcinomas". Oncology Letters 7.1 (2014): 189-194.
Chicago
Xiao, L., Zhao, E., Zhao, S., Zheng, X., Zheng, H., Takano, Y., Song, H."Paxillin expression is closely linked to the pathogenesis, progression and prognosis of gastric carcinomas". Oncology Letters 7, no. 1 (2014): 189-194. https://doi.org/10.3892/ol.2013.1686
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