Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
2014-February Volume 7 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
2014-February Volume 7 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

5‑FU and ixabepilone modify the microRNA expression profiles in MDA‑MB‑453 triple‑negative breast cancer cells

  • Authors:
    • Yongshan Yao
    • Shenghan Chen
    • Xin Zhou
    • Li Xie
    • Aijun Chen
  • View Affiliations / Copyright

    Affiliations: Third Department of General Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei 443003, P.R. China, Department of Electrocardiography, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei 443003, P.R. China
  • Pages: 541-547
    |
    Published online on: November 22, 2013
       https://doi.org/10.3892/ol.2013.1697
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

This study aimed to discover new potential mechanisms of chemotherapy with drugs used in the treatment of luminal androgen receptor (LAR)‑type triple‑negative breast cancer (TNBC). We examined the microRNA (miRNA) expression profiles of LAR‑type TNBC in vitro, and explored the variation in miRNA expression profiles in cells when treated with the chemotherapy drugs capecitabine and ixabepilone. The present study revealed that the expression levels of the three antitumor miRNAs, miR‑122a, miR‑145 and miR‑205, were significantly elevated in MDA‑MB‑453 LAR‑type TNBC tumor cells treated with 5‑fluorouracil together with ixabepilone. By contrast, carcinogenic miR‑296 miRNA expression significantly declined, and levels of several other miRNAs such as miR‑221, miR‑210, miR‑21 and miR‑10b were also altered. The drugs may exert their effects through the regulation of miRNA expression levels, thereby providing a theoretical basis for clinical implementation of miRNA expression profiles as a diagnostic method for the early diagnosis, classification and prognosis of breast cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Brenton JD, Carey LA, Ahmed AA and Caldas C: Molecular classification and molecular forecasting of breast cancer: ready for clinical application? J Clin Oncol. 23:7350–7360. 2005. View Article : Google Scholar

2 

de Ruijter TC, Veeck J, de Hoon JP, van Engeland M and Tjan-Heijnen VC: Characteristics of triple-negative breast cancer. J Cancer Res Clin Oncol. 137:183–192. 2011.PubMed/NCBI

3 

Foulkes WD, Smith IE and Reis-Filho JS: Triple-negative breast cancer. New Engl J Med. 363:1938–1948. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Peddi PF, Ellis MJ and Ma C: Molecular basis of triple negative breast cancer and implications for therapy. Int J Breast Cancer. 2012:2171852012. View Article : Google Scholar : PubMed/NCBI

5 

Yao-Lung K, Dar-Ren C and Tsai-Wang C: Clinicopathological features of triple-negative breast cancer in Taiwanese women. Int J Clin Oncol. 16:500–505. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Hall RE, Birrell SN, Tilley WD and Sutherland RL: MDA-MB-453, an androgen-responsive human breast carcinoma cell line with high level androgen receptor expression. Eur J Cancer. 30A:484–490. 1994. View Article : Google Scholar : PubMed/NCBI

7 

Lehmann BD, Bauer JA, Chen X, et al: Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest. 121:2750–2767. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Singh G, Odriozola L, Guan H, Kennedy CR and Chan AM: Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line. BMC Cancer. 11:4902011. View Article : Google Scholar : PubMed/NCBI

9 

Fornier M and Fumoleau P: The paradox of triple negative breast cancer: novel approaches to treatment. Breast J. 18:41–51. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Gucalp A and Traina TA: Triple-negative breast cancer: adjuvant therapeutic options. Chemother Res Pract. 2011:6962082011.PubMed/NCBI

11 

Yagata H, Kajiura Y and Yamauchi H: Current strategy for triple-negative breast cancer: appropriate combination of surgery, radiation, and chemotherapy. Breast Cancer. 18:165–173. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Minami CA, Chung DU and Chang HR: Management options in triple-negative breast cancer. Breast Cancer (Auckl). 5:175–199. 2011.PubMed/NCBI

13 

Rakha EA and Chan S: Metastatic triple-negative breast cancer. Clin Oncol (R Coll Radiol). 23:587–600. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Steponaviciene L, Lachej-Mikeroviene N, Smailyte G, Aleknavicius E, Meskauskas R and Didziapetriene J: Triple negative breast cancer: adjuvant chemotherapy effect on survival. Adv Med Sci. 56:285–290. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Wu J, Li S, Jia W and Su F: Response and prognosis of taxanes and anthracyclines neoadjuvant chemotherapy in patients with triple-negative breast cancer. J Cancer Res Clin Oncol. 137:1505–1510. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Brady-West DC and McGrowder DA: Triple negative breast cancer: therapeutic and prognostic implications. Asian Pac J Cancer Prev. 12:2139–2143. 2011.PubMed/NCBI

17 

Lee F, Jure-Kunkel MN and Salvati ME: Synergistic activity of ixabepilone plus other anticancer agents: preclinical and clinical evidence. Ther Adv Med Oncol. 3:11–25. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Fornier M: Ixabepilone plus capecitabine for breast cancer patients with an early metastatic relapse after adjuvant chemotherapy: two clinical trials. Clin Breast Cancer. 10:352–358. 2010. View Article : Google Scholar

19 

Perez EA, Patel T and Moreno-Aspitia A: Efficacy of ixabepilone in ER/PR/HER2-negative (triple-negative) breast cancer. Breast cancer Res Treat. 121:261–271. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Wang J, Fan Y and Xu B: Ixabepilone plus capecitabine for Chinese patients with metastatic breast cancer progressing after anthracycline and taxane treatment. Cancer Chemother Pharmacol. 66:597–603. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Jassem J, Fein L, Karwal M, et al: Ixabepilone plus capecitabine in advanced breast cancer patients with early relapse after adjuvant anthracyclines and taxanes: a pooled subset analysis of two phase III studies. Breast. 21:89–94. 2012. View Article : Google Scholar

22 

Li L, Li J, Yang K, et al: Ixabepilone plus capecitabine with capecitabine alone for metastatic breast cancer. Future Oncol. 6:201–207. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Roché H, Conte P, Perez EA, et al: Ixabepilone plus capecitabine in metastatic breast cancer patients with reduced performance status previously treated with anthracyclines and taxanes: a pooled analysis by performance status of efficacy and safety data from 2 phase III studies. Breast Cancer Res Treat. 125:755–765. 2011.

24 

Denduluri N and Swain S: Ixabepilone: clinical role in metastatic breast cancer. Clin Breast Cancer. 11:139–145. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Sparano JA, Vrdoljak E, Rixe O, et al: Randomized phase III trial of ixabepilone plus capecitabine versus capecitabine in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J Clin Oncol. 28:3256–3263. 2010. View Article : Google Scholar

26 

Yu Z, Baserga R, Chen L, Wang C, Lisanti MP and Pestell RG: microRNA, cell cycle, and human breast cancer. Am J Pathol. 176:1058–1064. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Shah MY, Pan X, Fix LN, Farwell MA and Zhang B: 5-Fluorouracil drug alters the microRNA expression profiles in MCF-7 breast cancer cells. J Cell Physiol. 226:1868–1878. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Kutanzi KR, Yurchenko OV, Beland FA, Checkhun VF and Pogribny IP: MicroRNA-mediated drug resistance in breast cancer. Clin Epigenetics. 2:171–185. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Andorfer CA, Necela BM, Thompson EA and Perez EA: MicroRNA signatures: clinical biomarkers for the diagnosis and treatment of breast cancer. Trends in Mol Med. 17:313–319. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Wang L and Wang J: MicroRNA-mediated breast cancer metastasis: from primary site to distant organs. Oncogene. 31:2499–2511. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Radojicic J, Zaravinos A, Vrekoussis T, Kafousi M, Spandidos DA and Stathopoulos EN: MicroRNA expression analysis in triple-negative (ER, PR and Her2/neu) breast cancer. Cell Cycle. 10:507–517. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Rothé F, Ignatiadis M, Chaboteaux C, et al: Global microRNA expression profiling identifies MiR-210 associated with tumor proliferation, invasion and poor clinical outcome in breast cancer. PloS One. 6:e209802011.

33 

Song B, Wang C, Liu J, et al: MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression. J Exp Clin Cancer Res. 29:292010. View Article : Google Scholar : PubMed/NCBI

34 

Yang L, Wei L, Zhao W, et al: Down-regulation of osteopontin expression by RNA interference affects cell proliferation and chemotherapy sensitivity of breast cancer MDA-MB-231 cells. Mol Med Rep. 5:373–376. 2012.PubMed/NCBI

35 

Liu H, Cao YD, Ye WX and Sun YY: Effect of microRNA-206 on cytoskeleton remodelling by downregulating Cdc42 in MDA-MB-231 cells. Tumori. 96:751–755. 2010.PubMed/NCBI

36 

Wang L, Shan BE, Sang MX, Lian YS, Wang B and Ding CY: Effect of microRNA-mediated p65 gene silencing on the proliferation and apoptosis of human breast cancer MDA-MB-231 cells. Nan Fang Yi Ke Da Xue Xue Bao. 31:1742–1747. 2011.(In Chinese).

37 

Varkonyi-Gasic E and Hellens RP: Quantitative stem-loop RT-PCR for detection of microRNAs. Methods Mol Biol. 744:145–157. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Scully OJ, Bay BH, Yip G and Yu Y: Breast cancer metastasis. Cancer Genomics Proteomics. 9:311–320. 2012.

39 

Iorio MV, Ferracin M, Liu CG, et al: MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 65:7065–7070. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:857–866. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Calin GA and Croce CM: MicroRNA-cancer connection: the beginning of a new tale. Cancer Res. 66:7390–7394. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Jeyaseelan K, Herath WB and Armugam A: MicroRNAs as therapeutic targets in human diseases. Expert Opin Ther Targets. 11:1119–1129. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Walko CM and Lindley C: Capecitabine: a review. Clin Ther. 27:23–44. 2005. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yao Y, Chen S, Zhou X, Xie L and Chen A: 5‑FU and ixabepilone modify the microRNA expression profiles in MDA‑MB‑453 triple‑negative breast cancer cells. Oncol Lett 7: 541-547, 2014.
APA
Yao, Y., Chen, S., Zhou, X., Xie, L., & Chen, A. (2014). 5‑FU and ixabepilone modify the microRNA expression profiles in MDA‑MB‑453 triple‑negative breast cancer cells. Oncology Letters, 7, 541-547. https://doi.org/10.3892/ol.2013.1697
MLA
Yao, Y., Chen, S., Zhou, X., Xie, L., Chen, A."5‑FU and ixabepilone modify the microRNA expression profiles in MDA‑MB‑453 triple‑negative breast cancer cells". Oncology Letters 7.2 (2014): 541-547.
Chicago
Yao, Y., Chen, S., Zhou, X., Xie, L., Chen, A."5‑FU and ixabepilone modify the microRNA expression profiles in MDA‑MB‑453 triple‑negative breast cancer cells". Oncology Letters 7, no. 2 (2014): 541-547. https://doi.org/10.3892/ol.2013.1697
Copy and paste a formatted citation
x
Spandidos Publications style
Yao Y, Chen S, Zhou X, Xie L and Chen A: 5‑FU and ixabepilone modify the microRNA expression profiles in MDA‑MB‑453 triple‑negative breast cancer cells. Oncol Lett 7: 541-547, 2014.
APA
Yao, Y., Chen, S., Zhou, X., Xie, L., & Chen, A. (2014). 5‑FU and ixabepilone modify the microRNA expression profiles in MDA‑MB‑453 triple‑negative breast cancer cells. Oncology Letters, 7, 541-547. https://doi.org/10.3892/ol.2013.1697
MLA
Yao, Y., Chen, S., Zhou, X., Xie, L., Chen, A."5‑FU and ixabepilone modify the microRNA expression profiles in MDA‑MB‑453 triple‑negative breast cancer cells". Oncology Letters 7.2 (2014): 541-547.
Chicago
Yao, Y., Chen, S., Zhou, X., Xie, L., Chen, A."5‑FU and ixabepilone modify the microRNA expression profiles in MDA‑MB‑453 triple‑negative breast cancer cells". Oncology Letters 7, no. 2 (2014): 541-547. https://doi.org/10.3892/ol.2013.1697
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team