Extramedullary plasmacytoma of the nasopharynx: A case report and review of the literature

Chang,Yen‑Liang; Chen,Po‑Yueh; Hung,Shih‑Han

doi:10.3892/ol.2013.1712

2014-February Volume 7 Issue 2

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

2014-February Volume 7 Issue 2

Full Size Image

Case Report

Extramedullary plasmacytoma of the nasopharynx: A case report and review of the literature

Authors:
- Yen‑Liang Chang
- Po‑Yueh Chen
- Shih‑Han Hung
View Affiliations / Copyright

Affiliations: Department of Otolaryngology Head & Neck Surgery, Cathay General Hospital, Taipei, Taiwan, R.O.C., Department of Otolaryngology Head & Neck Surgery, Taipei Medical University‑Shuang Ho Hospital, Taipei, Taiwan, R.O.C., Department of Otolaryngology, Taipei Medical University Hospital, Taipei, Taiwan, R.O.C.
Pages: 458-460
|
Published online on: November 27, 2013

https://doi.org/10.3892/ol.2013.1712
Expand metrics +

Abstract

Plasmacytoma is an extremely rare and discrete solitary mass of neoplastic monoclonal plasma cells. Extramedullary plasmacytoma (EMP) tends to occur during the fifth and seventh decades of life and is rarely diagnosed in younger patients. Only four cases of EMP have been previously reported in relatively young patients. Here we report a 15-year-old patient presenting with long-term nasal obstruction, who was found to have EMP of the nasopharynx. The patient was treated with surgery followed by radiotherapy with a satisfactory outcome. To the best of our knowledge, this study describes the the youngest individual with nasopharyngeal EMP to be reported in the literature.

View Figures

View References

1	Schridde H: Weitere Untersuchungen uber die Kornelungen der Plasmazellen. Centralbl Allg Pathol Anat. 16:433–435. 1905.(Article in German).
2	Fu YS and Perzin KH: Nonepithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx. A clinicopathologic study VI Fibrous tissue tumors (fibroma, fibromatosis, fibrosarcoma). Cancer. 37:2912–2928. 1976. View Article : Google Scholar
3	Knowling MA, Harwood AR and Bergsagel DE: Comparison of extramedullary plasmacytomas with solitary and multiple plasma cell tumors of bone. J Clin Oncol. 1:255–262. 1983.PubMed/NCBI
4	Galieni P, Cavo M, Pulsoni A, et al: Clinical outcome of extramedullary plasmacytoma. Haematologica. 85:47–51. 2000.
5	Miller FR, Lavertu P, Wanamaker JR, Bonafede J and Wood BG: Plasmacytomas of the head and neck. Otolaryngol Head Neck Surg. 119:614–618. 1998. View Article : Google Scholar : PubMed/NCBI
6	Nofsinger YC, Mirza N, Rowan PT, Lanza D and Weinstein G: Head and neck manifestations of plasma cell neoplasms. Laryngoscope. 107:741–746. 1997. View Article : Google Scholar
7	Straetmans J and Stokroos R: Extramedullary plasmacytomas in the head and neck region. Eur Arch Otorhinolaryngol. 265:1417–1423. 2008. View Article : Google Scholar : PubMed/NCBI
8	Soutar R, Lucraft H, Jackson G, et al: Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma. Br J Haematol. 124:717–726. 2004. View Article : Google Scholar
9	Mann G, Trebo MM, Minkov M, Simonitsch I, Chott A and Gadner H: Extramedullary plasmacytoma of the adenoids. Pediatr Blood Cancer. 48:361–362. 2007. View Article : Google Scholar : PubMed/NCBI
10	Nagasaka T, Lai R, Kuno K, Nakashima T and Nakashima N: Localized amyloidosis and extramedullary plasmacytoma involving the larynx of a child. Hum Pathol. 32:132–134. 2001. View Article : Google Scholar : PubMed/NCBI
11	Sharma MC, Mahapatra AK, Gaikwad S and Biswal A: Primary extramedullary orbital plasmacytoma in a child. Childs Nerv Syst. 12:470–472. 1996. View Article : Google Scholar : PubMed/NCBI
12	Sasaki R, Yasuda K, Abe E, et al: Multi-institutional analysis of solitary extramedullary plasmacytoma of the head and neck treated with curative radiotherapy. Int J Radiat Oncol Biol Phys. 82:626–634. 2012. View Article : Google Scholar : PubMed/NCBI
13	Sasaki S, Hashimoto K, Nakatsuka S, et al: Plasmablastic extramedullary plasmacytoma associated with Epstein-Barr virus arising in an immunocompetent patient with multiple myeloma. Intern Med. 50:2615–2620. 2011. View Article : Google Scholar
14	Susnerwala SS, Shanks JH, Banerjee SS, Scarffe JH, Farrington WT and Slevin NJ: Extramedullary plasmacytoma of the head and neck region: clinicopathological correlation in 25 cases. Br J Cancer. 75:921–927. 1997. View Article : Google Scholar : PubMed/NCBI
15	Chao MW, Gibbs P, Wirth A, Quong G, Guiney MJ and Liew KH: Radiotherapy in the management of solitary extramedullary plasmacytoma. Intern Med J. 35:211–215. 2005. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Extramedullary plasmacytoma of the nasopharynx: A case report and review of the literature

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Related Articles